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Year Number of Results
1979 2
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1987 5
1988 17
1989 22
1990 34
1991 46
1992 69
1993 104
1994 125
1995 96
1996 152
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1998 163
1999 179
2000 163
2001 189
2002 228
2003 268
2004 288
2005 276
2006 305
2007 350
2008 344
2009 347
2010 514
2011 556
2012 627
2013 685
2014 790
2015 861
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2017 1055
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2019 1166
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2021 1782
2022 1707
2023 1726
2024 2038
2025 790

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19,334 results

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Page 1
A current view on Tau protein phosphorylation in Alzheimer's disease.
Wegmann S, Biernat J, Mandelkow E. Wegmann S, et al. Curr Opin Neurobiol. 2021 Aug;69:131-138. doi: 10.1016/j.conb.2021.03.003. Epub 2021 Apr 21. Curr Opin Neurobiol. 2021. PMID: 33892381 Free article. Review.
The functions of the neuronal microtubule-associated protein Tau in the central nervous system are regulated by manifold posttranslational modifications at more than 50 sites. ...Elevated phosphorylation and aggregation of Tau are widely considered pathological hallmarks i …
The functions of the neuronal microtubule-associated protein Tau in the central nervous system are regulated by manifold posttranslat …
Photobiomodulation for Alzheimer's Disease: Translating Basic Research to Clinical Application.
Enengl J, Hamblin MR, Dungel P. Enengl J, et al. J Alzheimers Dis. 2020;75(4):1073-1082. doi: 10.3233/JAD-191210. J Alzheimers Dis. 2020. PMID: 32390621 Free PMC article. Review.
This review covers the literature on photobiomodulation therapy as a novel approach to prevent and treat Alzheimer's disease, aiming to bridge that gap by gathering together the terms and technical specifications into a single concise suggestion for a treatme …
This review covers the literature on photobiomodulation therapy as a novel approach to prevent and treat Alzheimer's diseas …
Translating the biology of aging into novel therapeutics for Alzheimer disease.
Hara Y, McKeehan N, Fillit HM. Hara Y, et al. Neurology. 2019 Jan 8;92(2):84-93. doi: 10.1212/WNL.0000000000006745. Epub 2018 Dec 7. Neurology. 2019. PMID: 30530798 Free PMC article. Review.
Aging is the leading risk factor for most chronic illnesses of old age, including Alzheimer disease (AD), a progressive neurodegenerative disease with currently no therapies that prevent, slow, or halt disease progression. ...
Aging is the leading risk factor for most chronic illnesses of old age, including Alzheimer disease (AD), a progressive neurod …
Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease.
Wesseling H, Mair W, Kumar M, Schlaffner CN, Tang S, Beerepoot P, Fatou B, Guise AJ, Cheng L, Takeda S, Muntel J, Rotunno MS, Dujardin S, Davies P, Kosik KS, Miller BL, Berretta S, Hedreen JC, Grinberg LT, Seeley WW, Hyman BT, Steen H, Steen JA. Wesseling H, et al. Cell. 2020 Dec 10;183(6):1699-1713.e13. doi: 10.1016/j.cell.2020.10.029. Epub 2020 Nov 13. Cell. 2020. PMID: 33188775 Free PMC article.
To elucidate the role of Tau isoforms and post-translational modification (PTM) stoichiometry in Alzheimer's disease (AD), we generated a high-resolution quantitative proteomics map of 95 PTMs on multiple isoforms of Tau isolated from postmortem human …
To elucidate the role of Tau isoforms and post-translational modification (PTM) stoichiometry in Alzheimer's disease …
Proteomic landscape of Alzheimer's Disease: novel insights into pathogenesis and biomarker discovery.
Bai B, Vanderwall D, Li Y, Wang X, Poudel S, Wang H, Dey KK, Chen PC, Yang K, Peng J. Bai B, et al. Mol Neurodegener. 2021 Aug 12;16(1):55. doi: 10.1186/s13024-021-00474-z. Mol Neurodegener. 2021. PMID: 34384464 Free PMC article. Review.
Mass spectrometry-based proteomics empowers deep profiling of proteome and protein posttranslational modifications (PTMs) in Alzheimer's disease (AD). Here we review the advances and limitations in historic and recent AD proteomic research. ...We discu …
Mass spectrometry-based proteomics empowers deep profiling of proteome and protein posttranslational modifications (PTMs) in Alzhe …
Tau Protein Interaction Partners and Their Roles in Alzheimer's Disease and Other Tauopathies.
Sinsky J, Pichlerova K, Hanes J. Sinsky J, et al. Int J Mol Sci. 2021 Aug 26;22(17):9207. doi: 10.3390/ijms22179207. Int J Mol Sci. 2021. PMID: 34502116 Free PMC article. Review.
In diseased conditions, several pathological modifications of tau protein manifest. These changes lead to tau protein aggregation and the formation of paired helical filaments (PHF) and neurofibrillary tangles (NFT), which are common hallmarks of Alzheimer' …
In diseased conditions, several pathological modifications of tau protein manifest. These changes lead to tau protein aggregat …
Tau liquid-liquid phase separation in neurodegenerative diseases.
Boyko S, Surewicz WK. Boyko S, et al. Trends Cell Biol. 2022 Jul;32(7):611-623. doi: 10.1016/j.tcb.2022.01.011. Epub 2022 Feb 15. Trends Cell Biol. 2022. PMID: 35181198 Free PMC article. Review.
Aggregation of the microtubule-associated protein tau plays a major role in Alzheimer's disease and several other neurodegenerative disorders. An exciting recent development is the finding that, akin to some other proteins associated with neurodegenera …
Aggregation of the microtubule-associated protein tau plays a major role in Alzheimer's disease and several othe …
Cellular and pathological functions of tau.
Parra Bravo C, Naguib SA, Gan L. Parra Bravo C, et al. Nat Rev Mol Cell Biol. 2024 Nov;25(11):845-864. doi: 10.1038/s41580-024-00753-9. Epub 2024 Jul 16. Nat Rev Mol Cell Biol. 2024. PMID: 39014245 Review.
Tau protein is involved in various cellular processes, including having a canonical role in binding and stabilization of microtubules in neurons. Tauopathies are neurodegenerative diseases marked by the abnormal accumulation of tau protein aggregates in neurons, as …
Tau protein is involved in various cellular processes, including having a canonical role in binding and stabilization of microtubules …
Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity.
Sorrentino V, Romani M, Mouchiroud L, Beck JS, Zhang H, D'Amico D, Moullan N, Potenza F, Schmid AW, Rietsch S, Counts SE, Auwerx J. Sorrentino V, et al. Nature. 2017 Dec 14;552(7684):187-193. doi: 10.1038/nature25143. Epub 2017 Dec 6. Nature. 2017. PMID: 29211722 Free PMC article.
Alzheimer's disease is a common and devastating disease characterized by aggregation of the amyloid-beta peptide. ...Our data support the relevance of enhancing mitochondrial proteostasis to delay amyloid-beta proteotoxic diseases, such as Alzheimer …
Alzheimer's disease is a common and devastating disease characterized by aggregation of the amyloid-beta peptide …
19,334 results
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