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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 2
1981 2
1982 1
1983 1
1984 2
1985 3
1986 8
1987 5
1988 17
1989 22
1990 34
1991 46
1992 69
1993 104
1994 125
1995 96
1996 152
1997 158
1998 163
1999 179
2000 163
2001 189
2002 228
2003 268
2004 288
2005 276
2006 305
2007 350
2008 344
2009 347
2010 515
2011 556
2012 627
2013 688
2014 792
2015 862
2016 981
2017 1057
2018 1045
2019 1171
2020 1449
2021 1783
2022 1710
2023 1718
2024 403

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17,152 results

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Page 1
A current view on Tau protein phosphorylation in Alzheimer's disease.
Wegmann S, Biernat J, Mandelkow E. Wegmann S, et al. Curr Opin Neurobiol. 2021 Aug;69:131-138. doi: 10.1016/j.conb.2021.03.003. Epub 2021 Apr 21. Curr Opin Neurobiol. 2021. PMID: 33892381 Free article. Review.
The functions of the neuronal microtubule-associated protein Tau in the central nervous system are regulated by manifold posttranslational modifications at more than 50 sites. ...Elevated phosphorylation and aggregation of Tau are widely considered pathological hallmarks i …
The functions of the neuronal microtubule-associated protein Tau in the central nervous system are regulated by manifold posttranslat …
Photobiomodulation for Alzheimer's Disease: Translating Basic Research to Clinical Application.
Enengl J, Hamblin MR, Dungel P. Enengl J, et al. J Alzheimers Dis. 2020;75(4):1073-1082. doi: 10.3233/JAD-191210. J Alzheimers Dis. 2020. PMID: 32390621 Free PMC article. Review.
This review covers the literature on photobiomodulation therapy as a novel approach to prevent and treat Alzheimer's disease, aiming to bridge that gap by gathering together the terms and technical specifications into a single concise suggestion for a treatme …
This review covers the literature on photobiomodulation therapy as a novel approach to prevent and treat Alzheimer's diseas
Proteomic landscape of Alzheimer's Disease: novel insights into pathogenesis and biomarker discovery.
Bai B, Vanderwall D, Li Y, Wang X, Poudel S, Wang H, Dey KK, Chen PC, Yang K, Peng J. Bai B, et al. Mol Neurodegener. 2021 Aug 12;16(1):55. doi: 10.1186/s13024-021-00474-z. Mol Neurodegener. 2021. PMID: 34384464 Free PMC article. Review.
Mass spectrometry-based proteomics empowers deep profiling of proteome and protein posttranslational modifications (PTMs) in Alzheimer's disease (AD). ...In particular, tau PTMs are correlated with disease stages and indicate the heterogeneity o …
Mass spectrometry-based proteomics empowers deep profiling of proteome and protein posttranslational modifications (PTMs) in Alzhe
Translating the biology of aging into novel therapeutics for Alzheimer disease.
Hara Y, McKeehan N, Fillit HM. Hara Y, et al. Neurology. 2019 Jan 8;92(2):84-93. doi: 10.1212/WNL.0000000000006745. Epub 2018 Dec 7. Neurology. 2019. PMID: 30530798 Free PMC article. Review.
Aging is the leading risk factor for most chronic illnesses of old age, including Alzheimer disease (AD), a progressive neurodegenerative disease with currently no therapies that prevent, slow, or halt disease progression. ...
Aging is the leading risk factor for most chronic illnesses of old age, including Alzheimer disease (AD), a progressive neurod …
Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease.
Wesseling H, Mair W, Kumar M, Schlaffner CN, Tang S, Beerepoot P, Fatou B, Guise AJ, Cheng L, Takeda S, Muntel J, Rotunno MS, Dujardin S, Davies P, Kosik KS, Miller BL, Berretta S, Hedreen JC, Grinberg LT, Seeley WW, Hyman BT, Steen H, Steen JA. Wesseling H, et al. Cell. 2020 Dec 10;183(6):1699-1713.e13. doi: 10.1016/j.cell.2020.10.029. Epub 2020 Nov 13. Cell. 2020. PMID: 33188775 Free PMC article.
To elucidate the role of Tau isoforms and post-translational modification (PTM) stoichiometry in Alzheimer's disease (AD), we generated a high-resolution quantitative proteomics map of 95 PTMs on multiple isoforms of Tau isolated from postmortem human …
To elucidate the role of Tau isoforms and post-translational modification (PTM) stoichiometry in Alzheimer's disease
Tau Protein Interaction Partners and Their Roles in Alzheimer's Disease and Other Tauopathies.
Sinsky J, Pichlerova K, Hanes J. Sinsky J, et al. Int J Mol Sci. 2021 Aug 26;22(17):9207. doi: 10.3390/ijms22179207. Int J Mol Sci. 2021. PMID: 34502116 Free PMC article. Review.
In diseased conditions, several pathological modifications of tau protein manifest. These changes lead to tau protein aggregation and the formation of paired helical filaments (PHF) and neurofibrillary tangles (NFT), which are common hallmarks of Alzheimer' …
In diseased conditions, several pathological modifications of tau protein manifest. These changes lead to tau protein aggregat …
Tau liquid-liquid phase separation in neurodegenerative diseases.
Boyko S, Surewicz WK. Boyko S, et al. Trends Cell Biol. 2022 Jul;32(7):611-623. doi: 10.1016/j.tcb.2022.01.011. Epub 2022 Feb 15. Trends Cell Biol. 2022. PMID: 35181198 Free PMC article. Review.
Aggregation of the microtubule-associated protein tau plays a major role in Alzheimer's disease and several other neurodegenerative disorders. ...Here, we discuss the evidence for tau LLPS in vitro, the molecular mechanisms of this reaction, and the ro …
Aggregation of the microtubule-associated protein tau plays a major role in Alzheimer's disease and several othe …
Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity.
Sorrentino V, Romani M, Mouchiroud L, Beck JS, Zhang H, D'Amico D, Moullan N, Potenza F, Schmid AW, Rietsch S, Counts SE, Auwerx J. Sorrentino V, et al. Nature. 2017 Dec 14;552(7684):187-193. doi: 10.1038/nature25143. Epub 2017 Dec 6. Nature. 2017. PMID: 29211722 Free PMC article.
Alzheimer's disease is a common and devastating disease characterized by aggregation of the amyloid-beta peptide. ...Our data support the relevance of enhancing mitochondrial proteostasis to delay amyloid-beta proteotoxic diseases, such as Alzheimer
Alzheimer's disease is a common and devastating disease characterized by aggregation of the amyloid-beta peptide
Etiology of Alzheimer's Disease.
Zhang C. Zhang C. Discov Med. 2023 Oct;35(178):757-776. doi: 10.24976/Discov.Med.202335178.71. Discov Med. 2023. PMID: 37811614 Review.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the primary cause of dementia in the elderly. ...Furthermore, the molecular findings on the pathogenetics of AD have provided translational proof-of-concept to intervene in AD, wh
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the primary cause of dementia in the elderly.
17,152 results
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