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Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E.
Aguilar-Valles A, Haji N, De Gregorio D, Matta-Camacho E, Eslamizade MJ, Popic J, Sharma V, Cao R, Rummel C, Tanti A, Wiebe S, Nuñez N, Comai S, Nadon R, Luheshi G, Mechawar N, Turecki G, Lacaille JC, Gobbi G, Sonenberg N. Aguilar-Valles A, et al. Nat Commun. 2018 Jun 25;9(1):2459. doi: 10.1038/s41467-018-04883-5. Nat Commun. 2018. PMID: 29941989 Free PMC article.
We investigated the involvement of MNK1/2 (MAPK-interacting serine/threonine-protein kinase 1 and 2) and their target, eIF4E (eukaryotic initiation factor 4E), in depression-like behavior in mice. ...TNFalpha inhibition in E …
We investigated the involvement of MNK1/2 (MAPK-interacting serine/threonine-protein kinase 1 and 2) and their target, eIF4E (euka
Loss of eIF4E Phosphorylation Engenders Depression-like Behaviors via Selective mRNA Translation.
Amorim IS, Kedia S, Kouloulia S, Simbriger K, Gantois I, Jafarnejad SM, Li Y, Kampaite A, Pooters T, Romanò N, Gkogkas CG. Amorim IS, et al. J Neurosci. 2018 Feb 21;38(8):2118-2133. doi: 10.1523/JNEUROSCI.2673-17.2018. Epub 2018 Jan 24. J Neurosci. 2018. PMID: 29367404 Free PMC article.
One of major endpoints of this signaling cascade is the 5' mRNA cap binding protein eIF4E (eukaryotic Initiation Factor 4E), which is phosphorylated on Ser 209 by MNK (MAPK-interacting protein kinases) and controls mRNA t
One of major endpoints of this signaling cascade is the 5' mRNA cap binding protein eIF4E (eukaryotic Initiation Fac