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1-Benzyl-N-[3-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl]pyrrolidine-2-carboxamide (Compound 24) antagonizes NOP receptor-mediated potassium channel activation in rat periaqueductal gray slices.
Liao YY, Trapella C, Chiou LC. Liao YY, et al. Among authors: trapella c. Eur J Pharmacol. 2009 Mar 15;606(1-3):84-9. doi: 10.1016/j.ejphar.2009.01.036. Epub 2009 Feb 1. Eur J Pharmacol. 2009. PMID: 19374842
Intrathecal administration of nociceptin/orphanin FQ receptor agonists in rats: A strategy to relieve chemotherapy-induced neuropathic hypersensitivity.
Micheli L, Di Cesare Mannelli L, Rizzi A, Guerrini R, Trapella C, Calò G, Ghelardini C. Micheli L, et al. Among authors: trapella c. Eur J Pharmacol. 2015 Nov 5;766:155-62. doi: 10.1016/j.ejphar.2015.10.005. Epub 2015 Oct 9. Eur J Pharmacol. 2015. PMID: 26450087
Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats.
Micheli L, Di Cesare Mannelli L, Guerrini R, Trapella C, Zanardelli M, Ciccocioppo R, Rizzi A, Ghelardini C, Calò G. Micheli L, et al. Among authors: trapella c. Eur J Pharmacol. 2015 May 5;754:73-81. doi: 10.1016/j.ejphar.2015.02.020. Epub 2015 Feb 19. Eur J Pharmacol. 2015. PMID: 25704616
Modulation of silent and constitutively active nociceptin/orphanin FQ receptors by potent receptor antagonists and Na+ ions in rat sympathetic neurons.
Mahmoud S, Margas W, Trapella C, Caló G, Ruiz-Velasco V. Mahmoud S, et al. Among authors: trapella c. Mol Pharmacol. 2010 May;77(5):804-17. doi: 10.1124/mol.109.062208. Epub 2010 Feb 16. Mol Pharmacol. 2010. PMID: 20159949 Free PMC article.
Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist Compound 24.
Fischetti C, Camarda V, Rizzi A, Pelà M, Trapella C, Guerrini R, McDonald J, Lambert DG, Salvadori S, Regoli D, Calo' G. Fischetti C, et al. Among authors: trapella c. Eur J Pharmacol. 2009 Jul 1;614(1-3):50-7. doi: 10.1016/j.ejphar.2009.04.054. Epub 2009 May 12. Eur J Pharmacol. 2009. PMID: 19445927
NOP receptor pharmacological profile - A dynamic mass redistribution study.
Malfacini D, Simon K, Trapella C, Guerrini R, Zaveri NT, Kostenis E, Calo' G. Malfacini D, et al. Among authors: trapella c. PLoS One. 2018 Aug 30;13(8):e0203021. doi: 10.1371/journal.pone.0203021. eCollection 2018. PLoS One. 2018. PMID: 30161182 Free PMC article.
Structure-activity studies on the nociceptin/orphanin FQ receptor antagonist 1-benzyl-N-{3-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl} pyrrolidine-2-carboxamide.
Trapella C, Fischetti C, Pela' M, Lazzari I, Guerrini R, Calo' G, Rizzi A, Camarda V, Lambert DG, McDonald J, Regoli D, Salvadori S. Trapella C, et al. Bioorg Med Chem. 2009 Jul 15;17(14):5080-95. doi: 10.1016/j.bmc.2009.05.068. Epub 2009 Jun 2. Bioorg Med Chem. 2009. PMID: 19527931
Pharmacological profile of NOP receptors coupled with calcium signaling via the chimeric protein G alpha qi5.
Camarda V, Fischetti C, Anzellotti N, Molinari P, Ambrosio C, Kostenis E, Regoli D, Trapella C, Guerrini R, Severo S, Calo G. Camarda V, et al. Among authors: trapella c. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jun;379(6):599-607. doi: 10.1007/s00210-009-0396-x. Epub 2009 Jan 28. Naunyn Schmiedebergs Arch Pharmacol. 2009. PMID: 19183962
Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vitro studies.
Spagnolo B, Carrà G, Fantin M, Fischetti C, Hebbes C, McDonald J, Barnes TA, Rizzi A, Trapella C, Fanton G, Morari M, Lambert DG, Regoli D, Calò G. Spagnolo B, et al. Among authors: trapella c. J Pharmacol Exp Ther. 2007 Jun;321(3):961-7. doi: 10.1124/jpet.106.116764. Epub 2007 Feb 28. J Pharmacol Exp Ther. 2007. PMID: 17329552
Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vivo studies.
Rizzi A, Gavioli EC, Marzola G, Spagnolo B, Zucchini S, Ciccocioppo R, Trapella C, Regoli D, Calò G. Rizzi A, et al. Among authors: trapella c. J Pharmacol Exp Ther. 2007 Jun;321(3):968-74. doi: 10.1124/jpet.106.116780. Epub 2007 Feb 28. J Pharmacol Exp Ther. 2007. PMID: 17329551
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