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4,5-Dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxy-benzyl)-phenyl]-amine (RO1138452) is a selective, pseudo-irreversible orthosteric antagonist at the prostacyclin (IP)-receptor expressed by human airway epithelial cells: IP-receptor-mediated inhibition of CXCL9 and CXCL10 release.
Ayer LM, Wilson SM, Traves SL, Proud D, Giembycz MA. Ayer LM, et al. Among authors: traves sl. J Pharmacol Exp Ther. 2008 Feb;324(2):815-26. doi: 10.1124/jpet.107.129312. Epub 2007 Oct 25. J Pharmacol Exp Ther. 2008. PMID: 17962517
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