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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 1
1987 2
1988 2
1989 1
1990 3
1991 2
1992 2
1993 2
1994 7
1995 7
1996 16
1997 22
1998 49
1999 88
2000 102
2001 163
2002 171
2003 226
2004 230
2005 286
2006 288
2007 321
2008 311
2009 295
2010 322
2011 318
2012 329
2013 343
2014 285
2015 260
2016 216
2017 200
2018 194
2019 179
2020 148
2021 158
2022 112
2023 9
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5,055 results
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Page 1
HDAC inhibitor Trichostatin A suppresses adipogenesis in 3T3-L1 preadipocytes.
Lv X, Qiu J, Hao T, Zhang H, Jiang H, Tan Y. Lv X, et al. Aging (Albany NY). 2021 Jul 7;13(13):17489-17498. doi: 10.18632/aging.203238. Epub 2021 Jul 7. Aging (Albany NY). 2021. PMID: 34232916 Free PMC article.
BACKGROUND AND PURPOSE: Obesity is becoming a major global health issue and is mainly induced by the accumulation of adipose tissues mediated by adipogenesis, which is reported to be regulated by peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT enhancer-bind …
BACKGROUND AND PURPOSE: Obesity is becoming a major global health issue and is mainly induced by the accumulation of adipose tissues mediate …
Trichostatin A ameliorates Alzheimer's disease-related pathology and cognitive deficits by increasing albumin expression and Aβ clearance in APP/PS1 mice.
Su Q, Li T, He PF, Lu XC, Yu Q, Gao QC, Wang ZJ, Wu MN, Yang D, Qi JS. Su Q, et al. Alzheimers Res Ther. 2021 Jan 4;13(1):7. doi: 10.1186/s13195-020-00746-8. Alzheimers Res Ther. 2021. PMID: 33397436 Free PMC article.
BACKGROUND: Alzheimer's disease (AD) is an intractable neurodegenerative disorder in the elderly population, currently lacking a cure. Trichostatin A (TSA), a histone deacetylase inhibitor, showed some neuroprotective roles, but its pathology-improvement effects in AD are …
BACKGROUND: Alzheimer's disease (AD) is an intractable neurodegenerative disorder in the elderly population, currently lacking a cure. Tr …
Trichostatin A mitigates radiation-induced teratogenesis in C57Bl/6 mice.
Haritwal T, Goyal N, Gupta N, Parvez S, Agrawala PK. Haritwal T, et al. Mutagenesis. 2021 Aug 27;36(4):303-309. doi: 10.1093/mutage/geab018. Mutagenesis. 2021. PMID: 34086940
Radiation exposure in utero is known to lead to serious concerns to both the mother and children, including developmental anomalies in the children. In the recent past, trichostatin A, an HDAC (histone deacetylase) inhibitor and epigenetic modifier, has been shown to mitig …
Radiation exposure in utero is known to lead to serious concerns to both the mother and children, including developmental anomalies in the c …
Eosinophil cell lines.
Ishihara K. Ishihara K. Methods Mol Biol. 2014;1178:45-51. doi: 10.1007/978-1-4939-1016-8_5. Methods Mol Biol. 2014. PMID: 24986606
In contrast, transient acetylation by histone deacetylase inhibitors such as trichostatin A does not induce eosinophilic differentiation. This chapter describes the maintenance of HL-60 clone 15 cells and EoL-1 cells and induction of the differentiation of these cell lines …
In contrast, transient acetylation by histone deacetylase inhibitors such as trichostatin A does not induce eosinophilic differentiat …
Trichostatin A sensitizes hepatoma cells to Taxol more than 5-Aza-dC and dexamethasone.
Donia T, Khedr S, Salim EI, Hessien M. Donia T, et al. Drug Metab Pers Ther. 2021 Apr 5;36(4):299-309. doi: 10.1515/dmpt-2020-0186. Drug Metab Pers Ther. 2021. PMID: 34773731
METHODS: Hepatoma cells (HepG2) were treated with the anticancer drug (Taxol), with a histone deacetylase inhibitor (Trichostatin A [TSA]), DNA methyltransferase inhibitor (5-Aza-dC) or dexamethasone (DEX). ...
METHODS: Hepatoma cells (HepG2) were treated with the anticancer drug (Taxol), with a histone deacetylase inhibitor (Trichostatin A [ …
Effects of trichostatin A on pig SCNT blastocyst formation rate and cell number: A meta-analysis.
Guo Z, Lv L, Liu D, Fu B. Guo Z, et al. Res Vet Sci. 2018 Apr;117:161-166. doi: 10.1016/j.rvsc.2017.12.011. Epub 2017 Dec 18. Res Vet Sci. 2018. PMID: 29277014 Review.
Although somatic cell nuclear transfer (SCNT) can be used to create transgenic pigs for human xenotransplantation, low efficiency limits its use. Trichostatin A (TSA) promotes SCNT embryo development, but whether TSA modifies SCNT blastocyst numbers is unclear. ...
Although somatic cell nuclear transfer (SCNT) can be used to create transgenic pigs for human xenotransplantation, low efficiency limits its …
Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A.
Park JW, Park SR, Han AR, Ban YH, Yoo YJ, Kim EJ, Kim E, Yoon YJ. Park JW, et al. J Nat Prod. 2011 May 27;74(5):1272-4. doi: 10.1021/np1006718. Epub 2011 Apr 19. J Nat Prod. 2011. PMID: 21504214
A new reduced hydroxamate, 2,3-dihydrotrichostatin A, was created from trichostatin A by employing a recombinant strain of Streptomyces venezuelae as a microbial catalyst. Compared with trichostatin A, 2,3-dihydrotrichostatin A showed similar antifungal activity aga …
A new reduced hydroxamate, 2,3-dihydrotrichostatin A, was created from trichostatin A by employing a recombinant strain of Streptomyc …
Effectiveness of trichostatin A as a potential candidate for anticancer therapy in non-small-cell lung cancer.
Mukhopadhyay NK, Weisberg E, Gilchrist D, Bueno R, Sugarbaker DJ, Jaklitsch MT. Mukhopadhyay NK, et al. Ann Thorac Surg. 2006 Mar;81(3):1034-42. doi: 10.1016/j.athoracsur.2005.06.059. Ann Thorac Surg. 2006. PMID: 16488717
METHODS: Trichostatin A (0.01 to 1.0 micromol/L) was applied to one normal lung fibroblast and four non-small-cell lung cancer lines, and its effect was determined by flow cytometry, annexin-V staining, immunoprecipitation, and Western blot analysis. ...Trichostatin …
METHODS: Trichostatin A (0.01 to 1.0 micromol/L) was applied to one normal lung fibroblast and four non-small-cell lung cancer lines, …
Trichostatin A, a histone deacetylase inhibitor suppresses NADPH Oxidase 4-Derived Redox Signalling and Angiogenesis.
Hakami NY, Dusting GJ, Peshavariya HM. Hakami NY, et al. J Cell Mol Med. 2016 Oct;20(10):1932-44. doi: 10.1111/jcmm.12885. Epub 2016 Jun 14. J Cell Mol Med. 2016. PMID: 27297729 Free PMC article.
In vivo angiogenic activity was assessed using subcutaneous sponge assay in C57Bl/6 and Nox4-deficient mice. Trichostatin A reduced Nox4 expression in a time- and concentration-dependent manner. ...Similarly intraperitoneal infusion of TSA (1 mg/kg) also suppressed TGFbeta …
In vivo angiogenic activity was assessed using subcutaneous sponge assay in C57Bl/6 and Nox4-deficient mice. Trichostatin A reduced N …
Trichostatin A and 5-Aza-2'-Deoxycytidine influence the expression of cold-induced genes in Arabidopsis.
Song Y, Liu L, Li G, An L, Tian L. Song Y, et al. Plant Signal Behav. 2017 Nov 2;12(11):e1389828. doi: 10.1080/15592324.2017.1389828. Epub 2017 Oct 13. Plant Signal Behav. 2017. PMID: 29027833 Free PMC article.
The results revealed that histone deacetylase inhibitors (trichostatin A) and DNA methylation inhibitors (5-Aza-2'-deoxycytosine) treatment enhanced cold tolerance. ...Our study indicated that Trichostatin A and 5-Aza-2'-Deoxycytidine can improve the plant cold resi …
The results revealed that histone deacetylase inhibitors (trichostatin A) and DNA methylation inhibitors (5-Aza-2'-deoxycytosine) tre …
5,055 results