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Page 1
Treatments of trimethylaminuria: where we are and where we might be heading.
Schmidt AC, Leroux JC. Schmidt AC, et al. Drug Discov Today. 2020 Sep;25(9):1710-1717. doi: 10.1016/j.drudis.2020.06.026. Epub 2020 Jun 29. Drug Discov Today. 2020. PMID: 32615074 Free article. Review.
Trimethylamine (TMA) is a volatile, foul-smelling, diet-derived amine, primarily generated in the colon and metabolized in the liver to its odorless N-oxide (TMAO). In primary trimethylaminuria (TMAU), an inherited deficiency in flavin-containing monooxygenase 3 leads to e …
Trimethylamine (TMA) is a volatile, foul-smelling, diet-derived amine, primarily generated in the colon and metabolized in the liver to its …
Saliva - Volatile Biomarkers and Profiles.
Milanowski M, Pomastowski P, Ligor T, Buszewski B. Milanowski M, et al. Crit Rev Anal Chem. 2017 May 4;47(3):251-266. doi: 10.1080/10408347.2016.1266925. Epub 2016 Dec 1. Crit Rev Anal Chem. 2017. PMID: 27905825 Review.
Some of them may serve as biomarkers of various diseases, such as dimethyl disulfide (halitosis), pyridine (periodontal disease) and trimethylamine (trimethylaminuria) or occupational exposure. The review shows the basic functions of saliva and its composition. ...
Some of them may serve as biomarkers of various diseases, such as dimethyl disulfide (halitosis), pyridine (periodontal disease) and trimeth …
The complex metabolism of trimethylamine in humans: endogenous and exogenous sources.
Chhibber-Goel J, Gaur A, Singhal V, Parakh N, Bhargava B, Sharma A. Chhibber-Goel J, et al. Expert Rev Mol Med. 2016 Apr 29;18:e8. doi: 10.1017/erm.2016.6. Expert Rev Mol Med. 2016. PMID: 27126549 Review.
It is synthesised from dietary constituents, including choline, L-carnitine, betaine and lecithin by the action of microbial enzymes during both healthy and diseased conditions in humans. Trimethylaminuria (TMAU) is a disease typified by its association with the characteri …
It is synthesised from dietary constituents, including choline, L-carnitine, betaine and lecithin by the action of microbial enzymes during …
Trimethylaminuria (fish-odour syndrome) and oral malodour.
Mitchell SC. Mitchell SC. Oral Dis. 2005;11 Suppl 1:10-3. doi: 10.1111/j.1601-0825.2005.01081.x. Oral Dis. 2005. PMID: 15752091 Review.
The aliphatic tertiary amine, trimethylamine, is such a volatile compound that is generated to excess in patients with a metabolic disorder known as trimethylaminuria (fish-odour syndrome). This article highlights this condition and draws attention to its potential role in …
The aliphatic tertiary amine, trimethylamine, is such a volatile compound that is generated to excess in patients with a metabolic disorder …
Halitosis: a review.
Feller L, Blignaut E. Feller L, et al. SADJ. 2005 Feb;60(1):17-9. SADJ. 2005. PMID: 15861957 Review.
In the remaining ten to twenty percent of cases, bad breath is caused by systemic disorders such as hepatic, pancreatic and nephritic insufficiencies, trimethylaminuria, upper and lower respiratory tract infection, medication and cases where gastric content may generate or …
In the remaining ten to twenty percent of cases, bad breath is caused by systemic disorders such as hepatic, pancreatic and nephritic insuff …
Biochemical and clinical aspects of the human flavin-containing monooxygenase form 3 (FMO3) related to trimethylaminuria.
Cashman JR, Camp K, Fakharzadeh SS, Fennessey PV, Hines RN, Mamer OA, Mitchell SC, Nguyen GP, Schlenk D, Smith RL, Tjoa SS, Williams DE, Yannicelli S. Cashman JR, et al. Curr Drug Metab. 2003 Apr;4(2):151-70. doi: 10.2174/1389200033489505. Curr Drug Metab. 2003. PMID: 12678693 Review.
Trimethylaminuria is a rare metabolic disorder that is associated with abnormal amounts of the dietary-derived trimethylamine. ...The remarkable progress in the biochemical, genetic, clinical basis for understanding the trimethylaminuria condition is summarized and
Trimethylaminuria is a rare metabolic disorder that is associated with abnormal amounts of the dietary-derived trimethylamine. ...The
Trimethylaminuria and a human FMO3 mutation database.
Hernandez D, Addou S, Lee D, Orengo C, Shephard EA, Phillips IR. Hernandez D, et al. Hum Mutat. 2003 Sep;22(3):209-13. doi: 10.1002/humu.10252. Hum Mutat. 2003. PMID: 12938085 Review.
Trimethylaminuria (TMAuria), or fish-odor syndrome, is due to defective flavin-containing monooxygenase 3 (FMO3). ...
Trimethylaminuria (TMAuria), or fish-odor syndrome, is due to defective flavin-containing monooxygenase 3 (FMO3). ...
Flavin-containing monooxygenases: mutations, disease and drug response.
Phillips IR, Shephard EA. Phillips IR, et al. Trends Pharmacol Sci. 2008 Jun;29(6):294-301. doi: 10.1016/j.tips.2008.03.004. Epub 2008 Apr 16. Trends Pharmacol Sci. 2008. PMID: 18423897 Free article. Review.
We then concentrate on the three FMOs (FMOs 1, 2 and 3) that are most important for metabolism of foreign chemicals in humans, focusing on the role of the FMOs and their genetic variants in disease and drug response. Loss-of-function mutations of FMO3 cause the disorder trimet
We then concentrate on the three FMOs (FMOs 1, 2 and 3) that are most important for metabolism of foreign chemicals in humans, focusing on t …
Halitosis. A common oral problem.
Spielman AI, Bivona P, Rifkin BR. Spielman AI, et al. N Y State Dent J. 1996 Dec;62(10):36-42. N Y State Dent J. 1996. PMID: 9002736 Review.
The remaining 10 percent of halitosis sufferers have systemic causes that include renal or hepatic failure, carcinomas, diabetes or trimethylaminuria. Modern analytical and microbiological techniques permit diagnosis of bad breath. ...
The remaining 10 percent of halitosis sufferers have systemic causes that include renal or hepatic failure, carcinomas, diabetes or trime
27 results