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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1943 1
1946 1
1947 1
1948 5
1949 2
1950 3
1951 7
1952 24
1953 54
1954 52
1955 115
1956 176
1957 250
1958 240
1959 274
1960 323
1961 380
1962 425
1963 596
1964 761
1965 591
1966 665
1967 805
1968 964
1969 906
1970 972
1971 1096
1972 1195
1973 1276
1974 1510
1975 1426
1976 1407
1977 1345
1978 1390
1979 1424
1980 1396
1981 1448
1982 1581
1983 1491
1984 1619
1985 1899
1986 1892
1987 1763
1988 1726
1989 1788
1990 1917
1991 1933
1992 2103
1993 1970
1994 1931
1995 1914
1996 2008
1997 2070
1998 2126
1999 2108
2000 2065
2001 2217
2002 2095
2003 2118
2004 2120
2005 2330
2006 2425
2007 2488
2008 2541
2009 2402
2010 2453
2011 2388
2012 2449
2013 2464
2014 2445
2015 2383
2016 2356
2017 2252
2018 2275
2019 2370
2020 2518
2021 2561
2022 2967
2023 2761
2024 2650
2025 2550
2026 857

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113,410 results

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Page 1
Triptans in the Acute Treatment of Migraine: A Systematic Review and Network Meta-Analysis.
Cameron C, Kelly S, Hsieh SC, Murphy M, Chen L, Kotb A, Peterson J, Coyle D, Skidmore B, Gomes T, Clifford T, Wells G. Cameron C, et al. Headache. 2015 Jul-Aug;55 Suppl 4:221-35. doi: 10.1111/head.12601. Epub 2015 Jul 14. Headache. 2015. PMID: 26178694
BACKGROUND: Although triptans are widely used in the acute management of migraine, there is uncertainty around the comparative efficacy of triptans among each other and vs non-triptan migraine treatments. ...Use of triptans in combination with ASA or a …
BACKGROUND: Although triptans are widely used in the acute management of migraine, there is uncertainty around the comparative effica …
Triptans and migraine: advances in use, administration, formulation, and development.
Macone AE, Perloff MD. Macone AE, et al. Expert Opin Pharmacother. 2017 Mar;18(4):387-397. doi: 10.1080/14656566.2017.1288721. Epub 2017 Feb 14. Expert Opin Pharmacother. 2017. PMID: 28129702 Review.
Recent triptan development has focused on new administration methods and formulations, triptan combination therapies, treatment in menstrually related migraines, and novel serotonin receptor subtype agonists (5HTf). ...Some new agents and device …
Recent triptan development has focused on new administration methods and formulations, triptan combination therapies, treatmen …
Drug Treatment of Cluster Headache.
Diener HC, May A. Diener HC, et al. Drugs. 2022 Jan;82(1):33-42. doi: 10.1007/s40265-021-01658-z. Epub 2021 Dec 17. Drugs. 2022. PMID: 34919214 Free PMC article. Review.
The 5-HT(1B) and 5-HT(1D) agonists in acute migraine therapy: Ergotamine, dihydroergotamine, and the triptans.
Whealy M, Becker WJ. Whealy M, et al. Handb Clin Neurol. 2024;199:17-42. doi: 10.1016/B978-0-12-823357-3.00008-2. Handb Clin Neurol. 2024. PMID: 38307644 Review.
Unlike the ergot alkaloids, the triptans do not activate many other receptor types, and therefore are much better tolerated. ...For optimal benefit, therapy needs to be individualized for a given patient both regarding the triptan chosen and the formulation. …
Unlike the ergot alkaloids, the triptans do not activate many other receptor types, and therefore are much better tolerated. . …
The Journey of the Non-Vascular Relief for Migraine: From 'Triptans' To 'Ditans'.
Xavier AS, Lakshmanan M, Gunaseelan V. Xavier AS, et al. Curr Clin Pharmacol. 2017;12(1):36-40. doi: 10.2174/1574884712666170419155048. Curr Clin Pharmacol. 2017. PMID: 28425871 Review.
This growing understanding helps to identify novel therapeutic targets for the management of migraine to treat the ailing migraineurs. The role of serotonin (5HT) in migraine is recognized to be the cornerstone for the currently available therapeutic options namely ergot a …
This growing understanding helps to identify novel therapeutic targets for the management of migraine to treat the ailing migraineurs. The r …
5-HT1F agonists.
Steel SJ. Steel SJ. Handb Clin Neurol. 2024;199:43-50. doi: 10.1016/B978-0-12-823357-3.00032-X. Handb Clin Neurol. 2024. PMID: 38307661 Review.
5-Hydroxytryptamine (HT)/serotonin receptor agonism has been a long-recognized property of triptan medications, and more recently, the study and development of medications with selective binding to the 1F receptor subtype have been explored. While the …
5-Hydroxytryptamine (HT)/serotonin receptor agonism has been a long-recognized property of triptan medications, and mor …
Eletriptan.
Sandrini G, Perrotta A, Tassorelli C, Nappi G. Sandrini G, et al. Expert Opin Drug Metab Toxicol. 2009 Dec;5(12):1587-98. doi: 10.1517/17425250903410226. Expert Opin Drug Metab Toxicol. 2009. PMID: 19929447 Review.
Symptomatic acute treatment of migraine should provide rapid and effective relief of the headache pain. The introduction of the 5-HT(1B/1D) receptor agonists (triptans) expanded the armamentarium for acute migraine pain treatment. Eletriptan is a second-gener …
Symptomatic acute treatment of migraine should provide rapid and effective relief of the headache pain. The introduction of the 5-HT(1B/1D) …
Cost-effectiveness of oral triptans for acute migraine: mixed treatment comparison.
Asseburg C, Peura P, Oksanen T, Turunen J, Purmonen T, Martikainen J. Asseburg C, et al. Int J Technol Assess Health Care. 2012 Oct;28(4):382-9. doi: 10.1017/S0266462312000517. Epub 2012 Sep 26. Int J Technol Assess Health Care. 2012. PMID: 23013610
BACKGROUND: The cost-effectiveness of triptans in the treatment of migraine has not been assessed since generic sumatriptan entered the Finnish market in 2008. METHODS: Using systematic review and mixed treatment comparison, the effectiveness of triptans was estimat …
BACKGROUND: The cost-effectiveness of triptans in the treatment of migraine has not been assessed since generic sumatriptan entered t …
Triptans attenuate circadian responses to light.
Basu P, Ie N, Wensel AL, Baskerville JD, Smith VM, Antle MC. Basu P, et al. Eur J Neurosci. 2015 Oct;42(7):2489-95. doi: 10.1111/ejn.13032. Epub 2015 Aug 25. Eur J Neurosci. 2015. PMID: 26228801
These responses to light can be modified by serotonergic drugs, such as serotonin 5HT1B receptor agonists. Triptans are specific 5HT1B agonists prescribed to treat migraines. ...Additionally, triptans may also affect the circadian clock i …
These responses to light can be modified by serotonergic drugs, such as serotonin 5HT1B receptor agonists. Triptans …
113,410 results
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