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Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets.
Zhang JC, Yao W, Hashimoto K. Zhang JC, et al. Curr Neuropharmacol. 2016;14(7):721-31. doi: 10.2174/1570159x14666160119094646. Curr Neuropharmacol. 2016. PMID: 26786147 Free PMC article. Review.
A recent paper showed that lipopolysaccharide (LPS)-induced inflammation gave rise to depression-like phenotype by altering BDNF-TrkB signaling in the prefrontal cortex, hippocampus, and nucleus accumbens, areas thought to be involved in the antidepressant ef …
A recent paper showed that lipopolysaccharide (LPS)-induced inflammation gave rise to depression-like phenotype by altering BDNF-TrkB
Inhibition of TrkB at the nucleus accumbens, using ANA-12, regulates basal and stress-induced orexin A expression within the mesolimbic system and affects anxiety, sociability and motivation.
Azogu I, Plamondon H. Azogu I, et al. Neuropharmacology. 2017 Oct;125:129-145. doi: 10.1016/j.neuropharm.2017.07.008. Epub 2017 Jul 11. Neuropharmacology. 2017. PMID: 28705440
An emerging biological substrate of depression and associated pathology is the nucleus accumbens (NAc), which through interactions with limbic, cognitive and motor circuits can regulate a variety of stress responses. ...These findings support a role for TrkB
An emerging biological substrate of depression and associated pathology is the nucleus accumbens (NAc), which through interact …
TrkB-dependent disinhibition of the nucleus accumbens is enhanced by ethanol.
Patton MH, Padgett KE, McKeon PN, Qadir H, Patton MS, Mu C, Roberts BM, Mathur BN. Patton MH, et al. Neuropsychopharmacology. 2019 May;44(6):1114-1122. doi: 10.1038/s41386-019-0341-8. Epub 2019 Feb 13. Neuropsychopharmacology. 2019. PMID: 30758322 Free PMC article.
Here we report the discovery of long-term depression of inhibitory synaptic transmission in the mouse nucleus accumbens core. ...Our findings support the emerging view that TrkB signaling regulates inhibitory synaptic plasticity and suggest this mechanism in …
Here we report the discovery of long-term depression of inhibitory synaptic transmission in the mouse nucleus accumbens core. …
Antidepressant effects of TrkB ligands on depression-like behavior and dendritic changes in mice after inflammation.
Zhang JC, Wu J, Fujita Y, Yao W, Ren Q, Yang C, Li SX, Shirayama Y, Hashimoto K. Zhang JC, et al. Int J Neuropsychopharmacol. 2014 Oct 31;18(4):pyu077. doi: 10.1093/ijnp/pyu077. Int J Neuropsychopharmacol. 2014. PMID: 25628381 Free PMC article.
METHODS: In this study, we examined the effects of TrkB agonist 7,8-dihydroxyflavone (7,8-DHF) and TrkB antagonist ANA-12 on depression-like behavior and morphological changes in mice previously exposed to lipopolysaccharide (LPS). Protein levels of BDNF, phospho- …
METHODS: In this study, we examined the effects of TrkB agonist 7,8-dihydroxyflavone (7,8-DHF) and TrkB antagonist ANA-12 on d …
TrkB in the hippocampus and nucleus accumbens differentially modulates depression-like behavior in mice.
De Vry J, Vanmierlo T, Martínez-Martínez P, Losen M, Temel Y, Boere J, Kenis G, Steckler T, Steinbusch HWM, Baets M, Prickaerts J. De Vry J, et al. Behav Brain Res. 2016 Jan 1;296:15-25. doi: 10.1016/j.bbr.2015.08.027. Epub 2015 Aug 24. Behav Brain Res. 2016. PMID: 26315459
Brain-derived neurotrophic factor (BDNF) exerts antidepressant-like effects in the hippocampus and pro-depressant effects in the nucleus accumbens (NAc). It is thought that downstream signaling of the BDNF receptor TrkB mediates the effects of BDNF in these b …
Brain-derived neurotrophic factor (BDNF) exerts antidepressant-like effects in the hippocampus and pro-depressant effects in the nucleus
Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex.
Verheij MM, Vendruscolo LF, Caffino L, Giannotti G, Cazorla M, Fumagalli F, Riva MA, Homberg JR, Koob GF, Contet C. Verheij MM, et al. J Neurosci. 2016 Aug 3;36(31):8149-59. doi: 10.1523/JNEUROSCI.2711-14.2016. J Neurosci. 2016. PMID: 27488635 Free PMC article.
Cocaine self-administration increased TrkB signaling and activated the downstream Akt pathway in the nucleus accumbens, and had opposite effects in the prefrontal cortex. ...In addition, although cocaine self-administration produced opposite effects on Trk
Cocaine self-administration increased TrkB signaling and activated the downstream Akt pathway in the nucleus accumbens, …
Effects of cocaine base paste on anxiety-like behavior and immediate-early gene expression in nucleus accumbens and medial prefrontal cortex of female mice.
Berardino BG, Fesser EA, Belluscio LM, Gianatiempo O, Pregi N, Cánepa ET. Berardino BG, et al. Psychopharmacology (Berl). 2019 Dec;236(12):3525-3539. doi: 10.1007/s00213-019-05321-0. Epub 2019 Jul 6. Psychopharmacology (Berl). 2019. PMID: 31280332
After abstinence, prefrontal cortex (mPFC) and nucleus accumbens (NAc) were isolated and gene expression analysis performed through real-time PCR. ...Egr1, FosB, ΔFosB, Arc, Bdnf, and TrkB expression was upregulated in CBP-injected mice in NAc and FosB, ΔFosB …
After abstinence, prefrontal cortex (mPFC) and nucleus accumbens (NAc) were isolated and gene expression analysis performed th …
Blockade of TrkB receptors in the nucleus accumbens prior to heterotypic stress alters corticotropin-releasing hormone (CRH), vesicular glutamate transporter 2 (vGluT2) and glucocorticoid receptor (GR) within the mesolimbic pathway.
Azogu I, Plamondon H. Azogu I, et al. Horm Behav. 2017 Apr;90:98-112. doi: 10.1016/j.yhbeh.2017.02.012. Epub 2017 Mar 15. Horm Behav. 2017. PMID: 28257759
ANA-12 also showed state-dependent effects at the NAc core, attenuating TrkB-ir in non-stress rats while reversing reduced expression in stressed rats. ...Together, these findings suggest that BDNF-mediated TrkB activation exerts differential impact in regulating em …
ANA-12 also showed state-dependent effects at the NAc core, attenuating TrkB-ir in non-stress rats while reversing reduced expression …
c-Fos, ΔFosB, BDNF, trkB and Arc Expression in the Limbic System of Male Roman High- and Low-Avoidance Rats that Show Differences in Sexual Behavior: Effect of Sexual Activity.
Sanna F, Poddighe L, Serra MP, Boi M, Bratzu J, Sanna F, Corda MG, Giorgi O, Melis MR, Argiolas A, Quartu M. Sanna F, et al. Neuroscience. 2019 Jan 1;396:1-23. doi: 10.1016/j.neuroscience.2018.11.002. Epub 2018 Nov 10. Neuroscience. 2019. PMID: 30423358
., c-Fos, ΔFosB (a truncated form of FosB), Brain-Derived Neurotrophic Factor (BDNF) and its tyrosine kinase receptor B (trkB) and Activity regulated cytoskeleton-associated (Arc) protein in the ventral tegmental area (VTA), nucleus accumbens (Acb) (core and …
., c-Fos, ΔFosB (a truncated form of FosB), Brain-Derived Neurotrophic Factor (BDNF) and its tyrosine kinase receptor B (trkB) and Ac …
R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects.
Yang C, Shirayama Y, Zhang JC, Ren Q, Yao W, Ma M, Dong C, Hashimoto K. Yang C, et al. Transl Psychiatry. 2015 Sep 1;5(9):e632. doi: 10.1038/tp.2015.136. Transl Psychiatry. 2015. PMID: 26327690 Free PMC article.
However, neither stereoisomer affected these alterations in the nucleus accumbens of depressed mice. In behavioral tests for side effects, S-ketamine, but not R-ketamine, precipitated behavioral abnormalities, such as hyperlocomotion, prepulse inhibition deficits an …
However, neither stereoisomer affected these alterations in the nucleus accumbens of depressed mice. In behavioral tests for s …
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