The efficacy of different cholinesterase reactivators (alloxyme, dietixyme, dipiroxyme, isonitrosine) used as specific antidotes) was evaluated in 78 patients with acute intoxications by phosphorus-organic insecticides. The most pronounced clinical effect was obtained with use of alloxyme and dietixyme. The number of side-effects was observed during employment of dietixyme. Use of dipiroxyme with isonitrosine was less effective and was connected with a higher number of side-effects.