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23 results
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Dnmt3a silences hematopoietic stem cell self-renewal.
Trowbridge JJ, Orkin SH. Trowbridge JJ, et al. Nat Genet. 2011 Dec 27;44(1):13-4. doi: 10.1038/ng.1043. Nat Genet. 2011. PMID: 22200773
PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer.
Hsu JH, Hubbell-Engler B, Adelmant G, Huang J, Joyce CE, Vazquez F, Weir BA, Montgomery P, Tsherniak A, Giacomelli AO, Perry JA, Trowbridge J, Fujiwara Y, Cowley GS, Xie H, Kim W, Novina CD, Hahn WC, Marto JA, Orkin SH. Hsu JH, et al. Cancer Res. 2017 Sep 1;77(17):4613-4625. doi: 10.1158/0008-5472.CAN-17-0216. Epub 2017 Jun 27. Cancer Res. 2017. PMID: 28655788 Free PMC article.
Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging.
Young K, Borikar S, Bell R, Kuffler L, Philip V, Trowbridge JJ. Young K, et al. Among authors: trowbridge jj. J Exp Med. 2016 Oct 17;213(11):2259-2267. doi: 10.1084/jem.20160168. Epub 2016 Oct 10. J Exp Med. 2016. PMID: 27811054 Free PMC article.
Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis.
Loberg MA, Bell RK, Goodwin LO, Eudy E, Miles LA, SanMiguel JM, Young K, Bergstrom DE, Levine RL, Schneider RK, Trowbridge JJ. Loberg MA, et al. Among authors: trowbridge jj. Leukemia. 2019 Jul;33(7):1635-1649. doi: 10.1038/s41375-018-0368-6. Epub 2019 Jan 28. Leukemia. 2019. PMID: 30692594 Free PMC article.
The Mediator of Hematopoietic Stem Cell Homeostasis.
Borikar S, Trowbridge JJ. Borikar S, et al. Among authors: trowbridge jj. Cell Stem Cell. 2016 Dec 1;19(6):677-678. doi: 10.1016/j.stem.2016.11.012. Cell Stem Cell. 2016. PMID: 27912086 Free PMC article.
Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A.
Xu J, Bauer DE, Kerenyi MA, Vo TD, Hou S, Hsu YJ, Yao H, Trowbridge JJ, Mandel G, Orkin SH. Xu J, et al. Among authors: trowbridge jj. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6518-23. doi: 10.1073/pnas.1303976110. Epub 2013 Apr 1. Proc Natl Acad Sci U S A. 2013. PMID: 23576758 Free PMC article.
A single cis element maintains repression of the key developmental regulator Gata2.
Snow JW, Trowbridge JJ, Fujiwara T, Emambokus NE, Grass JA, Orkin SH, Bresnick EH. Snow JW, et al. Among authors: trowbridge jj. PLoS Genet. 2010 Sep 9;6(9):e1001103. doi: 10.1371/journal.pgen.1001103. PLoS Genet. 2010. PMID: 20838598 Free PMC article.
Context-dependent function of "GATA switch" sites in vivo.
Snow JW, Trowbridge JJ, Johnson KD, Fujiwara T, Emambokus NE, Grass JA, Orkin SH, Bresnick EH. Snow JW, et al. Among authors: trowbridge jj. Blood. 2011 May 5;117(18):4769-72. doi: 10.1182/blood-2010-10-313031. Epub 2011 Mar 11. Blood. 2011. PMID: 21398579 Free PMC article.
DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells.
Trowbridge JJ, Snow JW, Kim J, Orkin SH. Trowbridge JJ, et al. Cell Stem Cell. 2009 Oct 2;5(4):442-9. doi: 10.1016/j.stem.2009.08.016. Cell Stem Cell. 2009. PMID: 19796624 Free PMC article.
Hematopoietic stem cell biology: too much of a Wnt thing.
Trowbridge JJ, Moon RT, Bhatia M. Trowbridge JJ, et al. Nat Immunol. 2006 Oct;7(10):1021-3. doi: 10.1038/ni1006-1021. Nat Immunol. 2006. PMID: 16985497 No abstract available.
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