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Quantitative live cell imaging of a tauopathy model enables the identification of a polypharmacological drug candidate that restores physiological microtubule interaction.
Pinzi L, Conze C, Bisi N, Torre GD, Soliman A, Monteiro-Abreu N, Trushina NI, Krusenbaum A, Dolouei MK, Hellwig A, Christodoulou MS, Passarella D, Bakota L, Rastelli G, Brandt R. Pinzi L, et al. Among authors: trushina ni. Nat Commun. 2024 Feb 23;15(1):1679. doi: 10.1038/s41467-024-45851-6. Nat Commun. 2024. PMID: 38396035 Free PMC article.
Super-resolution imaging and quantitative analysis of microtubule arrays in model neurons show that epothilone D increases the density but decreases the length and straightness of microtubules in axon-like processes.
Conze C, Trushina NI, Holtmannspötter M, Rierola M, Attanasio S, Bakota L, Piehler J, Brandt R. Conze C, et al. Among authors: trushina ni. Brain Res Bull. 2022 Nov;190:234-243. doi: 10.1016/j.brainresbull.2022.10.008. Epub 2022 Oct 13. Brain Res Bull. 2022. PMID: 36244582 Free PMC article.
19 results