Special Issue "Tryptophan in Nutrition and Health 3.0".
Int J Mol Sci. 2025.
PMID: 40943365
Free PMC article.
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Special Issue "Tryptophan in Nutrition and Health 3.0".
Int J Mol Sci. 2025 Aug 30;26(17):8443. doi: 10.3390/ijms26178443.
Int J Mol Sci. 2025.
PMID: 40943365
Free PMC article.
Tryptophan is the rate-limiting essential amino acid and thus a building block of life that is needed for protein synthesis [...]....
Tryptophan is the rate-limiting essential amino acid and thus a building block of life that is needed for protein synthesis [...]....
Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
Gastroenterology. 2022 Nov;163(5):1294-1305.e3. doi: 10.1053/j.gastro.2022.07.052. Epub 2022 Aug 6.
Gastroenterology. 2022.
PMID: 35940251
Free article.
Clinical Trial.
Secondary outcomes included changes in serum tryptophan metabolites, Functional Assessment of Chronic Illness Therapy Fatigue scale, and scores for depression, anxiety, and stress. ...RESULTS: During 5-hydroxytryptophan treatment, a significant increase in serum 5-hydroxyt …
Secondary outcomes included changes in serum tryptophan metabolites, Functional Assessment of Chronic Illness Therapy Fatigue scale, …
Are dietary amino acids prospectively predicts changes in serum lipid profile?
Diabetes Metab Syndr. 2019 May-Jun;13(3):1837-1843. doi: 10.1016/j.dsx.2019.04.013. Epub 2019 Apr 17.
Diabetes Metab Syndr. 2019.
PMID: 31235103
Clinical Trial.
RESULTS: The median(IQR) changes in triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were 6.0(-19.0, -35.5), 9.0(7.0, -24.0), 1.0(-3.0, -6.0), and 5.2(-8.0, -18.6) mg/dl, …
RESULTS: The median(IQR) changes in triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and low density …
Supplementing healthy women with up to 5.0 g/d of L-tryptophan has no adverse effects.
J Nutr. 2013 Jun;143(6):859-66. doi: 10.3945/jn.112.173823. Epub 2013 Apr 24.
J Nutr. 2013.
PMID: 23616514
Free article.
Clinical Trial.
Because of the frequent use of L-tryptophan (L-Trp) in dietary supplements, determination of the no-observed-adverse-effect-level is desirable for public health purposes. ...The participants were randomly assigned to receive placebo (0 g/d) or 1.0, 2.0, 3 …
Because of the frequent use of L-tryptophan (L-Trp) in dietary supplements, determination of the no-observed-adverse-effect-level is …
Effects of combined intraduodenal administration of lauric acid and L-tryptophan on postprandial plasma glucose, glucoregulatory hormones and gastric emptying in type 2 diabetes: a double-blind, randomised, crossover study.
Diabetologia. 2026 Apr;69(4):900-910. doi: 10.1007/s00125-025-06630-0. Epub 2025 Dec 19.
Diabetologia. 2026.
PMID: 41419616
Clinical Trial.
AIMS/HYPOTHESIS: In healthy men, lauric acid (C12) and L-tryptophan (Trp), when administered intraduodenally in loads of 1.26 and 0.42 kJ/min (0.3 and 0.1 kcal/min), respectively, that are individually ineffective, stimulate glucagon-like peptide-1 (GLP-1) an …
AIMS/HYPOTHESIS: In healthy men, lauric acid (C12) and L-tryptophan (Trp), when administered intraduodenally in loads of 1.26 and 0.4 …
Dietary tryptophan supplementation induces a transient immune enhancement of gilthead seabream (Sparus aurata) juveniles fed fishmeal-free diets.
Fish Shellfish Immunol. 2019 Oct;93:240-250. doi: 10.1016/j.fsi.2019.07.033. Epub 2019 Jul 13.
Fish Shellfish Immunol. 2019.
PMID: 31310850
However, several diseases can affect farmed fish and it is imperative to find alternatives for chemotherapeutic treatments when disease outbreaks occur. Maintenance of health through nutrition is well-establish in modern animal farming, and amino acids (AA) are prom …
However, several diseases can affect farmed fish and it is imperative to find alternatives for chemotherapeutic treatments when disease outb …
Pre-Sleep Alpha-Lactalbumin Supplementation Does Not Improve the Habitual Sleep and Performance of Sportspeople with Sleep Difficulties.
Nutrients. 2025 Mar 29;17(7):1196. doi: 10.3390/nu17071196.
Nutrients. 2025.
PMID: 40218954
Free PMC article.
Clinical Trial.
Background: Many athletes experience sleep difficulties, and prior research within this cohort suggests that acute supplementation of alpha-lactalbumin (ALAC), a whey protein rich in the amino acid tryptophan, may improve sleep and performance. Therefore, this study invest …
Background: Many athletes experience sleep difficulties, and prior research within this cohort suggests that acute supplementation of alpha- …
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