Tsamandouras N - Search Results

1

Combining the 'bottom up' and 'top down' approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data.

Tsamandouras N, Rostami-Hodjegan A, Aarons L. Tsamandouras N, et al. Br J Clin Pharmacol. 2015 Jan;79(1):48-55. doi: 10.1111/bcp.12234. Br J Clin Pharmacol. 2015. PMID: 24033787 Free PMC article. Review.

2

Reduction of a Whole-Body Physiologically Based Pharmacokinetic Model to Stabilise the Bayesian Analysis of Clinical Data.

Wendling T, Tsamandouras N, Dumitras S, Pigeolet E, Ogungbenro K, Aarons L. Wendling T, et al. Among authors: tsamandouras n. AAPS J. 2016 Jan;18(1):196-209. doi: 10.1208/s12248-015-9840-7. Epub 2015 Nov 4. AAPS J. 2016. PMID: 26538125 Free PMC article.

3

Incorporation of stochastic variability in mechanistic population pharmacokinetic models: handling the physiological constraints using normal transformations.

Tsamandouras N, Wendling T, Rostami-Hodjegan A, Galetin A, Aarons L. Tsamandouras N, et al. J Pharmacokinet Pharmacodyn. 2015 Aug;42(4):349-73. doi: 10.1007/s10928-015-9418-0. Epub 2015 May 26. J Pharmacokinet Pharmacodyn. 2015. PMID: 26006250

4

Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach.

Tsamandouras N, Dickinson G, Guo Y, Hall S, Rostami-Hodjegan A, Galetin A, Aarons L. Tsamandouras N, et al. Pharm Res. 2015 Jun;32(6):1864-83. doi: 10.1007/s11095-014-1581-2. Epub 2014 Dec 2. Pharm Res. 2015. PMID: 25446771 Clinical Trial.

5

Reduced physiologically-based pharmacokinetic model of repaglinide: impact of OATP1B1 and CYP2C8 genotype and source of in vitro data on the prediction of drug-drug interaction risk.

Gertz M, Tsamandouras N, Säll C, Houston JB, Galetin A. Gertz M, et al. Among authors: tsamandouras n. Pharm Res. 2014 Sep;31(9):2367-82. doi: 10.1007/s11095-014-1333-3. Epub 2014 Mar 13. Pharm Res. 2014. PMID: 24623479

6

Modelling of atorvastatin pharmacokinetics and the identification of the effect of a BCRP polymorphism in the Japanese population.

Tsamandouras N, Guo Y, Wendling T, Hall S, Galetin A, Aarons L. Tsamandouras N, et al. Pharmacogenet Genomics. 2017 Jan;27(1):27-38. doi: 10.1097/FPC.0000000000000252. Pharmacogenet Genomics. 2017. PMID: 27787353

7

Identification of the effect of multiple polymorphisms on the pharmacokinetics of simvastatin and simvastatin acid using a population-modeling approach.

Tsamandouras N, Dickinson G, Guo Y, Hall S, Rostami-Hodjegan A, Galetin A, Aarons L. Tsamandouras N, et al. Clin Pharmacol Ther. 2014 Jul;96(1):90-100. doi: 10.1038/clpt.2014.55. Epub 2014 Mar 5. Clin Pharmacol Ther. 2014. PMID: 24598718

8

Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies.

Tsamandouras N, Chen WLK, Edington CD, Stokes CL, Griffith LG, Cirit M. Tsamandouras N, et al. AAPS J. 2017 Sep;19(5):1499-1512. doi: 10.1208/s12248-017-0122-4. Epub 2017 Jul 27. AAPS J. 2017. PMID: 28752430 Free PMC article.

9

Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System.

Tsamandouras N, Kostrzewski T, Stokes CL, Griffith LG, Hughes DJ, Cirit M. Tsamandouras N, et al. J Pharmacol Exp Ther. 2017 Jan;360(1):95-105. doi: 10.1124/jpet.116.237495. Epub 2016 Oct 19. J Pharmacol Exp Ther. 2017. PMID: 27760784 Free PMC article.

10

Capsaicin-evoked cough responses in asthmatic patients: Evidence for airway neuronal dysfunction.

Satia I, Tsamandouras N, Holt K, Badri H, Woodhead M, Ogungbenro K, Felton TW, O'Byrne PM, Fowler SJ, Smith JA. Satia I, et al. Among authors: tsamandouras n. J Allergy Clin Immunol. 2017 Mar;139(3):771-779.e10. doi: 10.1016/j.jaci.2016.04.045. Epub 2016 Jun 15. J Allergy Clin Immunol. 2017. PMID: 27444176 Free article.

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