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Anticancer effects of garlic and garlic-derived compounds for breast cancer control.
Tsubura A, Lai YC, Kuwata M, Uehara N, Yoshizawa K. Tsubura A, et al. Anticancer Agents Med Chem. 2011 Mar;11(3):249-53. doi: 10.2174/187152011795347441. Anticancer Agents Med Chem. 2011. PMID: 21269259 Review.
DADS synergizes the effect of eicosapentaenoic acid, a breast cancer suppressor, and antagonizes the effect of linoleic acid, a breast cancer enhancer. ...
DADS synergizes the effect of eicosapentaenoic acid, a breast cancer suppressor, and antagonizes the effect of linoleic acid, a
Effects of Dietary Xanthophylls, Canthaxanthin and Astaxanthin on N-Methyl-N-nitrosourea-induced Rat Mammary Carcinogenesis.
Yuri T, Yoshizawa K, Emoto Y, Kinoshita Y, Yuki M, Tsubura A. Yuri T, et al. Among authors: tsubura a. In Vivo. 2016 11-12;30(6):795-800. doi: 10.21873/invivo.10996. In Vivo. 2016. PMID: 27815463
Curcumin suppresses N-methyl-N-nitrosourea-induced photoreceptor apoptosis in Sprague-Dawley rats.
Emoto Y, Yoshizawa K, Uehara N, Kinoshita Y, Yuri T, Shikata N, Tsubura A. Emoto Y, et al. Among authors: tsubura a. In Vivo. 2013 Sep-Oct;27(5):583-90. In Vivo. 2013. PMID: 23988891
A single intraperitoneal (i.p.) injection of N-methyl-N-nitrosourea (MNU), an alkylating agent, causes photoreceptor cell apoptosis within seven days in rats. Curcumin is a polyphenolic natural product with pluripotent properties including antioxidant activity. The
A single intraperitoneal (i.p.) injection of N-methyl-N-nitrosourea (MNU), an alkylating agent, causes photoreceptor cell apoptosis w
Effects of prepubertal indole-3-carbinol treatment on development of N-methyl-N-nitrosourea-induced mammary carcinomas in female Sprague-Dawley rats.
Shimano N, Uehara N, Kiyozuka Y, Shikata N, Tsubura A. Shimano N, et al. Among authors: tsubura a. In Vivo. 2007 Nov-Dec;21(6):983-8. In Vivo. 2007. PMID: 18210745
Rats were sacrificed at 34 weeks of age or when their largest mammary tumor reached a diameter of > or =1 cm. Body weight gain, vaginal opening, estrous cyclicity and mammary carcinogenesis were compared between the groups. ...I3C treatment before and after MNU administ …
Rats were sacrificed at 34 weeks of age or when their largest mammary tumor reached a diameter of > or =1 cm. Body weight gain, va …
PARP inhibitors accelerate N-methyl-N-nitrosourea-induced cataractogenesis in Sprague-Dawley rats.
Miki K, Yoshizawa K, Uehara N, Yuri T, Matsuoka Y, Tsubura A. Miki K, et al. Among authors: tsubura a. In Vivo. 2007 Sep-Oct;21(5):739-44. In Vivo. 2007. PMID: 18019406
MATERIALS AND METHODS: A single intraperitoneal injection of 70 mg/kg MNU was administered to 15-day-old male and female Sprague-Dawley rats. ...At 28 days after MNU, mature cataracts were observed Nicotinamide significantly accelerated lens opacity and cataractogenesis, a …
MATERIALS AND METHODS: A single intraperitoneal injection of 70 mg/kg MNU was administered to 15-day-old male and female Sprague-Dawl …
Effects of prepubertal zeranol exposure on estrogen target organs and N-methyl-N-nitrosourea-induced mammary tumorigenesis in female Sprague-Dawley rats.
Yuri T, Nikaido Y, Shimano N, Uehara N, Shikata N, Tsubura A. Yuri T, et al. Among authors: tsubura a. In Vivo. 2004 Nov-Dec;18(6):755-61. In Vivo. 2004. PMID: 15646816
Human chorionic gonadotropin suppresses human breast cancer cell growth directly via p53-mediated mitochondrial apoptotic pathway and indirectly via ovarian steroid secretion.
Yuri T, Kinoshita Y, Emoto Y, Yoshizawa K, Tsubura A. Yuri T, et al. Among authors: tsubura a. Anticancer Res. 2014 Mar;34(3):1347-54. Anticancer Res. 2014. PMID: 24596382
In cell viability assays, hCG inhibited the growth of three human breast cancer cell lines (estrogen receptor (ER)-positive KPL-1 and MCF-7, and ER-negative MKL-F cells), and the growth inhibition activity of hCG was most pronounced against KPL-1 cells (luteinizing hormone/chorio …
In cell viability assays, hCG inhibited the growth of three human breast cancer cell lines (estrogen receptor (ER)-positive KPL-1 and MCF-7, …
Dietary factors modifying breast cancer risk and relation to time of intake.
Tsubura A, Uehara N, Kiyozuka Y, Shikata N. Tsubura A, et al. J Mammary Gland Biol Neoplasia. 2005 Jan;10(1):87-100. doi: 10.1007/s10911-005-2543-4. J Mammary Gland Biol Neoplasia. 2005. PMID: 15886889 Review.
A diet high in n-3 polyunsaturated fatty acid (PUFA) or monounsaturated fatty acid (MUFA) and low in n-6 PUFA is protective against breast cancer. ...Time of intake appears to be important: lifetime protection may be achieved if one is exposed to a dietary factor th
A diet high in n-3 polyunsaturated fatty acid (PUFA) or monounsaturated fatty acid (MUFA) and low in n-6 PUFA is protective against b
Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells.
Kanematsu S, Uehara N, Miki H, Yoshizawa K, Kawanaka A, Yuri T, Tsubura A. Kanematsu S, et al. Among authors: tsubura a. Anticancer Res. 2010 Sep;30(9):3381-90. Anticancer Res. 2010. PMID: 20944112
In MDA-MB-231 cells, 30 μM SFN caused S and G2/M cell-cycle arrest associated with increased p21WAF1 and p27KIP1 levels and decreased cyclin A, cyclin B1 and CDC2 levels. ...CONCLUSION: These results indicate a cytoprotective role of autophagy against SFN-induced ap …
In MDA-MB-231 cells, 30 μM SFN caused S and G2/M cell-cycle arrest associated with increased p21WAF1 and p27KIP1 levels and decreased cyclin …
Biphasic effects of zeranol on the growth of estrogen receptor-positive human breast carcinoma cells.
Yuri T, Tsukamoto R, Miki K, Uehara N, Matsuoka Y, Tsubura A. Yuri T, et al. Among authors: tsubura a. Oncol Rep. 2006 Dec;16(6):1307-12. Oncol Rep. 2006. PMID: 17089054
Zeranol (alpha-zearalanol) is a metabolite of the mycoestrogen zearalenone, and is used as a growth promoter of livestock due to its strong estrogenic activity. ...High-dose zeranol induced the formation of a sub-G1 fraction and the up-regulation of the apopt …
Zeranol (alpha-zearalanol) is a metabolite of the mycoestrogen zearalenone, and is used as a growth promoter of livestock due …
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