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Theobromine, the primary methylxanthine found in Theobroma cacao, prevents malignant glioblastoma proliferation by negatively regulating phosphodiesterase-4, extracellular signal-regulated kinase, Akt/mammalian target of rapamycin kinase, and nuclear factor-kappa B.
Sugimoto N, Miwa S, Hitomi Y, Nakamura H, Tsuchiya H, Yachie A. Sugimoto N, et al. Among authors: tsuchiya h. Nutr Cancer. 2014;66(3):419-23. doi: 10.1080/01635581.2013.877497. Epub 2014 Feb 18. Nutr Cancer. 2014. PMID: 24547961
Borderline chondrosarcoma of long and flat bones.
Tsuchiya H, Ueda Y, Morishita H, Nonomura A, Kawashima A, Fellinger EJ, Tomita K. Tsuchiya H, et al. J Cancer Res Clin Oncol. 1993;119(6):363-8. doi: 10.1007/BF01208847. J Cancer Res Clin Oncol. 1993. PMID: 8449973
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