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921 results
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Inhibitory effect of novel somatostatin peptide analogues on human cancer cell growth based on the selective inhibition of DNA polymerase β.
Kuriyama I, Miyazaki A, Tsuda Y, Yoshida H, Mizushina Y. Kuriyama I, et al. Bioorg Med Chem. 2013 Jan 15;21(2):403-11. doi: 10.1016/j.bmc.2012.11.024. Epub 2012 Nov 29. Bioorg Med Chem. 2013. PMID: 23266186
Plasmin inhibitors with hydrophobic amino acid-based linker between hydantoin moiety and benzimidazole scaffold enhance inhibitory activity.
Teno N, Gohda K, Yamashita Y, Otsubo T, Yamaguchi M, Wanaka K, Tsuda Y. Teno N, et al. Bioorg Med Chem Lett. 2016 May 1;26(9):2259-61. doi: 10.1016/j.bmcl.2016.03.047. Epub 2016 Mar 15. Bioorg Med Chem Lett. 2016. PMID: 27009905
Inhibition of plasmin protects against colitis in mice by suppressing matrix metalloproteinase 9-mediated cytokine release from myeloid cells.
Munakata S, Tashiro Y, Nishida C, Sato A, Komiyama H, Shimazu H, Dhahri D, Salama Y, Eiamboonsert S, Takeda K, Yagita H, Tsuda Y, Okada Y, Nakauchi H, Sakamoto K, Heissig B, Hattori K. Munakata S, et al. Gastroenterology. 2015 Mar;148(3):565-578.e4. doi: 10.1053/j.gastro.2014.12.001. Epub 2014 Dec 6. Gastroenterology. 2015. PMID: 25490065
Active site-directed plasmin inhibitors: Extension on the P2 residue.
Hidaka K, Gohda K, Teno N, Wanaka K, Tsuda Y. Hidaka K, et al. Bioorg Med Chem. 2016 Feb 15;24(4):545-53. doi: 10.1016/j.bmc.2015.12.009. Epub 2015 Dec 8. Bioorg Med Chem. 2016. PMID: 26732532
New cyclic somatostatin analogues containing a pyrazinone ring: importance of Tyr for antiproliferative activity.
Miyazaki A, Tsuda Y, Fukushima S, Yokoi T, Vántus T, Bökönyi G, Szabó E, Horváth A, Kéri G, Okada Y. Miyazaki A, et al. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6199-201. doi: 10.1016/j.bmcl.2008.10.001. Epub 2008 Oct 5. Bioorg Med Chem Lett. 2008. PMID: 18930401
A Novel Prodrug of a γ-Glutamylcyclotransferase Inhibitor Suppresses Cancer Cell Proliferation in vitro and Inhibits Tumor Growth in a Xenograft Mouse Model of Prostate Cancer.
Ii H, Yoshiya T, Nakata S, Taniguchi K, Hidaka K, Tsuda S, Mochizuki M, Nishiuchi Y, Tsuda Y, Ito K, Kageyama S, Yoshiki T. Ii H, et al. ChemMedChem. 2018 Jan 22;13(2):155-163. doi: 10.1002/cmdc.201700660. Epub 2018 Jan 9. ChemMedChem. 2018. PMID: 29316360
The role of plasmin in the pathogenesis of murine multiple myeloma.
Eiamboonsert S, Salama Y, Watarai H, Dhahri D, Tsuda Y, Okada Y, Hattori K, Heissig B. Eiamboonsert S, et al. Biochem Biophys Res Commun. 2017 Jun 24;488(2):387-392. doi: 10.1016/j.bbrc.2017.05.062. Epub 2017 May 10. Biochem Biophys Res Commun. 2017. PMID: 28501622
The structure-activity relationship of various YO compounds, novel plasmin inhibitors, in the apoptosis induction.
Enomoto R, Sugahara C, Komai T, Suzuki C, Kinoshita N, Hosoda A, Yoshikawa A, Tsuda Y, Okada Y, Lee E. Enomoto R, et al. Biochim Biophys Acta. 2004 Nov 1;1674(3):291-8. doi: 10.1016/j.bbagen.2004.07.004. Biochim Biophys Acta. 2004. PMID: 15541298
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