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KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development.
Tsukada Y, Ishitani T, Nakayama KI. Tsukada Y, et al. Genes Dev. 2010 Mar 1;24(5):432-7. doi: 10.1101/gad.1864410. Genes Dev. 2010. PMID: 20194436 Free PMC article.
Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation.
Someya K, Nakatsukasa H, Ito M, Kondo T, Tateda KI, Akanuma T, Koya I, Sanosaka T, Kohyama J, Tsukada YI, Takamura-Enya T, Yoshimura A. Someya K, et al. Int Immunol. 2017 Aug 1;29(8):365-375. doi: 10.1093/intimm/dxx049. Int Immunol. 2017. PMID: 29048538 Free PMC article.
Hydroxylation mediates chromatin demethylation.
Tsukada Y. Tsukada Y. J Biochem. 2012 Mar;151(3):229-46. doi: 10.1093/jb/mvs003. Epub 2012 Jan 13. J Biochem. 2012. PMID: 22247561 Review.
In vitro histone demethylase assay.
Tsukada Y, Nakayama KI. Tsukada Y, et al. Cold Spring Harb Protoc. 2010 Oct 1;2010(10):pdb.prot5512. doi: 10.1101/pdb.prot5512. Cold Spring Harb Protoc. 2010. PMID: 20889709
[Histone methylation and demethylation--focusing on demethylation--].
Tsukada Y. Tsukada Y. Seikagaku. 2007 Jul;79(7):691-7. Seikagaku. 2007. PMID: 17763704 Review. Japanese. No abstract available.
CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis.
Nishiyama M, Oshikawa K, Tsukada Y, Nakagawa T, Iemura S, Natsume T, Fan Y, Kikuchi A, Skoultchi AI, Nakayama KI. Nishiyama M, et al. Among authors: tsukada y. Nat Cell Biol. 2009 Feb;11(2):172-82. doi: 10.1038/ncb1831. Epub 2009 Jan 18. Nat Cell Biol. 2009. PMID: 19151705 Free PMC article.
Maternal TET3 is dispensable for embryonic development but is required for neonatal growth.
Tsukada Y, Akiyama T, Nakayama KI. Tsukada Y, et al. Sci Rep. 2015 Oct 28;5:15876. doi: 10.1038/srep15876. Sci Rep. 2015. PMID: 26507142 Free PMC article.
Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposons.
Hatanaka Y, Inoue K, Oikawa M, Kamimura S, Ogonuki N, Kodama EN, Ohkawa Y, Tsukada Y, Ogura A. Hatanaka Y, et al. Among authors: tsukada y. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14641-6. doi: 10.1073/pnas.1512775112. Epub 2015 Nov 6. Proc Natl Acad Sci U S A. 2015. PMID: 26546670 Free PMC article.
Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.
Suzuki T, Ozasa H, Itoh Y, Zhan P, Sawada H, Mino K, Walport L, Ohkubo R, Kawamura A, Yonezawa M, Tsukada Y, Tumber A, Nakagawa H, Hasegawa M, Sasaki R, Mizukami T, Schofield CJ, Miyata N. Suzuki T, et al. Among authors: tsukada y. J Med Chem. 2013 Sep 26;56(18):7222-31. doi: 10.1021/jm400624b. Epub 2013 Sep 5. J Med Chem. 2013. PMID: 23964788 Free PMC article.
The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b).
He J, Kallin EM, Tsukada Y, Zhang Y. He J, et al. Among authors: tsukada y. Nat Struct Mol Biol. 2008 Nov;15(11):1169-75. doi: 10.1038/nsmb.1499. Epub 2008 Oct 5. Nat Struct Mol Biol. 2008. PMID: 18836456 Free PMC article.
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