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Camptothecin (CPT) directly binds to human heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and inhibits the hnRNP A1/topoisomerase I interaction.
Manita D, Toba Y, Takakusagi Y, Matsumoto Y, Kusayanagi T, Takakusagi K, Tsukuda S, Takada K, Kanai Y, Kamisuki S, Sakaguchi K, Sugawara F. Manita D, et al. Among authors: tsukuda s. Bioorg Med Chem. 2011 Dec 15;19(24):7690-7. doi: 10.1016/j.bmc.2011.09.059. Epub 2011 Oct 5. Bioorg Med Chem. 2011. PMID: 22071521
Exploration of the binding proteins of perfluorooctane sulfonate by a T7 phage display screen.
Miyano Y, Tsukuda S, Sakimoto I, Takeuchi R, Shimura S, Takahashi N, Kusayanagi T, Takakusagi Y, Okado M, Matsumoto Y, Takakusagi K, Takeuchi T, Kamisuki S, Nakazaki A, Ohta K, Miura M, Kuramochi K, Mizushina Y, Kobayashi S, Sugawara F, Sakaguchi K. Miyano Y, et al. Among authors: tsukuda s. Bioorg Med Chem. 2012 Jul 1;20(13):3985-90. doi: 10.1016/j.bmc.2012.05.016. Epub 2012 May 15. Bioorg Med Chem. 2012. PMID: 22658539
The antitumor agent doxorubicin binds to Fanconi anemia group F protein.
Kusayanagi T, Tsukuda S, Shimura S, Manita D, Iwakiri K, Kamisuki S, Takakusagi Y, Takeuchi T, Kuramochi K, Nakazaki A, Sakaguchi K, Kobayashi S, Sugawara F. Kusayanagi T, et al. Among authors: tsukuda s. Bioorg Med Chem. 2012 Nov 1;20(21):6248-55. doi: 10.1016/j.bmc.2012.09.015. Epub 2012 Sep 16. Bioorg Med Chem. 2012. PMID: 23026082
Ridaifen G, tamoxifen analog, is a potent anticancer drug working through a combinatorial association with multiple cellular factors.
Ikeda K, Kamisuki S, Uetake S, Mizusawa A, Ota N, Sasaki T, Tsukuda S, Kusayanagi T, Takakusagi Y, Morohashi K, Yamori T, Dan S, Shiina I, Sugawara F. Ikeda K, et al. Among authors: tsukuda s. Bioorg Med Chem. 2015 Sep 15;23(18):6118-24. doi: 10.1016/j.bmc.2015.08.001. Epub 2015 Aug 5. Bioorg Med Chem. 2015. PMID: 26314924
A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide.
Kaneko M, Watashi K, Kamisuki S, Matsunaga H, Iwamoto M, Kawai F, Ohashi H, Tsukuda S, Shimura S, Suzuki R, Aizaki H, Sugiyama M, Park SY, Ito T, Ohtani N, Sugawara F, Tanaka Y, Mizokami M, Sureau C, Wakita T. Kaneko M, et al. Among authors: tsukuda s. J Virol. 2015 Dec;89(23):11945-53. doi: 10.1128/JVI.01855-15. Epub 2015 Sep 16. J Virol. 2015. PMID: 26378168 Free PMC article.
Novel anticancer agent, SQAP, binds to focal adhesion kinase and modulates its activity.
Izaguirre-Carbonell J, Kawakubo H, Murata H, Tanabe A, Takeuchi T, Kusayanagi T, Tsukuda S, Hirakawa T, Iwabata K, Kanai Y, Ohta K, Miura M, Sakaguchi K, Matsunaga S, Sahara H, Kamisuki S, Sugawara F. Izaguirre-Carbonell J, et al. Among authors: tsukuda s. Sci Rep. 2015 Oct 12;5:15136. doi: 10.1038/srep15136. Sci Rep. 2015. PMID: 26456697 Free PMC article.
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