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Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
Adachi O, Kawai T, Takeda K, Matsumoto M, Tsutsui H, Sakagami M, Nakanishi K, Akira S. Adachi O, et al. Immunity. 1998 Jul;9(1):143-50. doi: 10.1016/s1074-7613(00)80596-8. Immunity. 1998. PMID: 9697844
Propionibacterium acnes treatment diminishes CD4+ NK1.1+ T cells but induces type I T cells in the liver by induction of IL-12 and IL-18 production from Kupffer cells.
Matsui K, Yoshimoto T, Tsutsui H, Hyodo Y, Hayashi N, Hiroishi K, Kawada N, Okamura H, Nakanishi K, Higashino K. Matsui K, et al. J Immunol. 1997 Jul 1;159(1):97-106. J Immunol. 1997. PMID: 9200444
Defective NK cell activity and Th1 response in IL-18-deficient mice.
Takeda K, Tsutsui H, Yoshimoto T, Adachi O, Yoshida N, Kishimoto T, Okamura H, Nakanishi K, Akira S. Takeda K, et al. Immunity. 1998 Mar;8(3):383-90. doi: 10.1016/s1074-7613(00)80543-9. Immunity. 1998. PMID: 9529155
Regulation of interferon-gamma production by IL-12 and IL-18.
Okamura H, Kashiwamura S, Tsutsui H, Yoshimoto T, Nakanishi K. Okamura H, et al. Curr Opin Immunol. 1998 Jun;10(3):259-64. doi: 10.1016/s0952-7915(98)80163-5. Curr Opin Immunol. 1998. PMID: 9638361 Review.
Interleukin-18: a novel cytokine that augments both innate and acquired immunity.
Okamura H, Tsutsui H, Kashiwamura S, Yoshimoto T, Nakanishi K. Okamura H, et al. Adv Immunol. 1998;70:281-312. doi: 10.1016/s0065-2776(08)60389-2. Adv Immunol. 1998. PMID: 9755340 Review. No abstract available.
Hepatocyte growth factor gene therapy of liver cirrhosis in rats.
Ueki T, Kaneda Y, Tsutsui H, Nakanishi K, Sawa Y, Morishita R, Matsumoto K, Nakamura T, Takahashi H, Okamoto E, Fujimoto J. Ueki T, et al. Nat Med. 1999 Feb;5(2):226-30. doi: 10.1038/5593. Nat Med. 1999. PMID: 9930873
IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor.
Hyodo Y, Matsui K, Hayashi N, Tsutsui H, Kashiwamura S, Yamauchi H, Hiroishi K, Takeda K, Tagawa Y, Iwakura Y, Kayagaki N, Kurimoto M, Okamura H, Hada T, Yagita H, Akira S, Nakanishi K, Higashino K. Hyodo Y, et al. J Immunol. 1999 Feb 1;162(3):1662-8. J Immunol. 1999. PMID: 9973427
IL-18-deficient mice are resistant to endotoxin-induced liver injury but highly susceptible to endotoxin shock.
Sakao Y, Takeda K, Tsutsui H, Kaisho T, Nomura F, Okamura H, Nakanishi K, Akira S. Sakao Y, et al. Int Immunol. 1999 Mar;11(3):471-80. doi: 10.1093/intimm/11.3.471. Int Immunol. 1999. PMID: 10221659
Serum level of tumor necrosis factor (TNF)-alpha were markedly elevated (approximately 10-fold higher) within 1.5 h after LPS challenge in IL-18KO mice as compared with wild-type mice. ...
Serum level of tumor necrosis factor (TNF)-alpha were markedly elevated (approximately 10-fold higher) within 1.5 h after LPS challen …
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