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890 results
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Physiologically-based pharmacokinetics in drug development and regulatory science.
Rowland M, Peck C, Tucker G. Rowland M, et al. Among authors: tucker g. Annu Rev Pharmacol Toxicol. 2011;51:45-73. doi: 10.1146/annurev-pharmtox-010510-100540. Annu Rev Pharmacol Toxicol. 2011. PMID: 20854171 Review.
Prediction of in vivo drug clearance from in vitro data. I: impact of inter-individual variability.
Howgate EM, Rowland Yeo K, Proctor NJ, Tucker GT, Rostami-Hodjegan A. Howgate EM, et al. Among authors: tucker gt. Xenobiotica. 2006 Jun;36(6):473-97. doi: 10.1080/00498250600683197. Xenobiotica. 2006. PMID: 16769646
Enantiomer-specific pharmacokinetics.
Tucker GT. Tucker GT. Acta Pharm Nord. 1990;2(3):193-6. Acta Pharm Nord. 1990. PMID: 2200430 Review. No abstract available.
The rational selection of drug interaction studies: implications of recent advances in drug metabolism.
Tucker GT. Tucker GT. Int J Clin Pharmacol Ther Toxicol. 1992 Nov;30(11):550-3. Int J Clin Pharmacol Ther Toxicol. 1992. PMID: 1490831 Review. No abstract available.
Analysis of solvent central nervous system toxicity and ethanol interactions using a human population physiologically based kinetic and dynamic model.
MacDonald AJ, Rostami-Hodjegan A, Tucker GT, Linkens DA. MacDonald AJ, et al. Among authors: tucker gt. Regul Toxicol Pharmacol. 2002 Apr;35(2 Pt 1):165-76. doi: 10.1006/rtph.2001.1507. Regul Toxicol Pharmacol. 2002. PMID: 12052002
Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential--towards a consensus.
Tucker GT, Houston JB, Huang SM. Tucker GT, et al. Br J Clin Pharmacol. 2001 Jul;52(1):107-17. doi: 10.1046/j.0306-5251.2001.temp.1441.x. Br J Clin Pharmacol. 2001. PMID: 11453898 Free PMC article. Review. No abstract available.
Prediction of intestinal first-pass drug metabolism.
Yang J, Jamei M, Yeo KR, Tucker GT, Rostami-Hodjegan A. Yang J, et al. Curr Drug Metab. 2007 Oct;8(7):676-84. doi: 10.2174/138920007782109733. Curr Drug Metab. 2007. PMID: 17979655 Review.
Simulation and prediction of in vivo drug metabolism in human populations from in vitro data.
Rostami-Hodjegan A, Tucker GT. Rostami-Hodjegan A, et al. Nat Rev Drug Discov. 2007 Feb;6(2):140-8. doi: 10.1038/nrd2173. Nat Rev Drug Discov. 2007. PMID: 17268485 Review.
Incorporating in vitro information on drug metabolism into clinical trial simulations to assess the effect of CYP2D6 polymorphism on pharmacokinetics and pharmacodynamics: dextromethorphan as a model application.
Dickinson GL, Rezaee S, Proctor NJ, Lennard MS, Tucker GT, Rostami-Hodjegan A. Dickinson GL, et al. J Clin Pharmacol. 2007 Feb;47(2):175-86. doi: 10.1177/0091270006294279. J Clin Pharmacol. 2007. PMID: 17244768
Differences in cytochrome p450-mediated pharmacokinetics between chinese and caucasian populations predicted by mechanistic physiologically based pharmacokinetic modelling.
Barter ZE, Tucker GT, Rowland-Yeo K. Barter ZE, et al. Clin Pharmacokinet. 2013 Dec;52(12):1085-100. doi: 10.1007/s40262-013-0089-y. Clin Pharmacokinet. 2013. PMID: 23818090
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