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Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential--toward a consensus.

Tucker GT, Houston JB, Huang SM. Tucker GT, et al. Pharm Res. 2001 Aug;18(8):1071-80. doi: 10.1023/a:1010994022294. Pharm Res. 2001. PMID: 11587475 Review. No abstract available.

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Drug metabolism.

Tucker GT. Tucker GT. Br J Anaesth. 1979 Jul;51(7):603-18. doi: 10.1093/bja/51.7.603. Br J Anaesth. 1979. PMID: 399191 Review. No abstract available.

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The 1'-hydroxylation of Rac-bufuralol by rat brain microsomes.

Coleman T, Spellman EF, Rostami-Hodjegan A, Lennard MS, Tucker GT. Coleman T, et al. Among authors: tucker gt. Drug Metab Dispos. 2000 Sep;28(9):1094-9. Drug Metab Dispos. 2000. PMID: 10950855

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Population-based modeling to demonstrate extrapancreatic effects of tolbutamide.

Rostami-Hodjegan A, Peacey SR, George E, Heller SR, Tucker GT. Rostami-Hodjegan A, et al. Among authors: tucker gt. Am J Physiol. 1998 Apr;274(4):E758-71. doi: 10.1152/ajpendo.1998.274.4.E758. Am J Physiol. 1998. PMID: 9575839

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Prediction of in vivo drug clearance from in vitro data. I: impact of inter-individual variability.

Howgate EM, Rowland Yeo K, Proctor NJ, Tucker GT, Rostami-Hodjegan A. Howgate EM, et al. Among authors: tucker gt. Xenobiotica. 2006 Jun;36(6):473-97. doi: 10.1080/00498250600683197. Xenobiotica. 2006. PMID: 16769646

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Prediction of metabolic drug clearance in humans: in vitro-in vivo extrapolation vs allometric scaling.

Shiran MR, Proctor NJ, Howgate EM, Rowland-Yeo K, Tucker GT, Rostami-Hodjegan A. Shiran MR, et al. Among authors: tucker gt. Xenobiotica. 2006 Jul;36(7):567-80. doi: 10.1080/00498250600761662. Xenobiotica. 2006. PMID: 16864504

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Clinical implications of genetic polymorphism in drug metabolism.

Tucker GT. Tucker GT. J Pharm Pharmacol. 1994 May;46 Suppl 1:417-24. J Pharm Pharmacol. 1994. PMID: 8064560 Review. No abstract available.

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Safety in numbers. The role of pharmacokinetics in local anesthetic toxicity: the 1993 ASRA Lecture.

Tucker GT. Tucker GT. Reg Anesth. 1994 May-Jun;19(3):155-63. Reg Anesth. 1994. PMID: 7999649 Review. No abstract available.

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Testing for bimodality in frequency distributions of data suggesting polymorphisms of drug metabolism--hypothesis testing.

Jackson PR, Tucker GT, Woods HF. Jackson PR, et al. Among authors: tucker gt. Br J Clin Pharmacol. 1989 Dec;28(6):655-62. doi: 10.1111/j.1365-2125.1989.tb03558.x. Br J Clin Pharmacol. 1989. PMID: 2611088 Free PMC article.

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Testing for bimodality in frequency distributions of data suggesting polymorphisms of drug metabolism--histograms and probit plots.

Jackson PR, Tucker GT, Woods HF. Jackson PR, et al. Among authors: tucker gt. Br J Clin Pharmacol. 1989 Dec;28(6):647-53. doi: 10.1111/j.1365-2125.1989.tb03557.x. Br J Clin Pharmacol. 1989. PMID: 2611087 Free PMC article.

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