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Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema.
Yoshida T, Mett I, Bhunia AK, Bowman J, Perez M, Zhang L, Gandjeva A, Zhen L, Chukwueke U, Mao T, Richter A, Brown E, Ashush H, Notkin N, Gelfand A, Thimmulappa RK, Rangasamy T, Sussan T, Cosgrove G, Mouded M, Shapiro SD, Petrache I, Biswal S, Feinstein E, Tuder RM. Yoshida T, et al. Among authors: tuder rm. Nat Med. 2010 Jul;16(7):767-73. doi: 10.1038/nm.2157. Epub 2010 May 16. Nat Med. 2010. PMID: 20473305 Free PMC article.
RTP801 is required for ceramide-induced cell-specific death in the murine lung.
Kamocki K, Van Demark M, Fisher A, Rush NI, Presson RG Jr, Hubbard W, Berdyshev EV, Adamsky S, Feinstein E, Gandjeva A, Tuder RM, Petrache I. Kamocki K, et al. Among authors: tuder rm. Am J Respir Cell Mol Biol. 2013 Jan;48(1):87-93. doi: 10.1165/rcmb.2012-0254OC. Epub 2012 Sep 28. Am J Respir Cell Mol Biol. 2013. PMID: 23024063 Free PMC article.
Rtp801 suppression of epithelial mTORC1 augments endotoxin-induced lung inflammation.
Nadon AM, Perez MJ, Hernandez-Saavedra D, Smith LP, Yang Y, Sanders LA, Gandjeva A, Chabon J, Koyanagi DE, Graham BB, Tuder RM, Schmidt EP. Nadon AM, et al. Among authors: tuder rm. Am J Pathol. 2014 Sep;184(9):2382-9. doi: 10.1016/j.ajpath.2014.06.002. Epub 2014 Jul 9. Am J Pathol. 2014. PMID: 25016184 Free PMC article.
Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine oxidoreductase in ventilator-induced lung injury.
Le A, Damico R, Damarla M, Boueiz A, Pae HH, Skirball J, Hasan E, Peng X, Chesley A, Crow MT, Reddy SP, Tuder RM, Hassoun PM. Le A, et al. Among authors: tuder rm. J Appl Physiol (1985). 2008 Oct;105(4):1282-90. doi: 10.1152/japplphysiol.90689.2008. Epub 2008 Jul 31. J Appl Physiol (1985). 2008. PMID: 18669934 Free PMC article.
Mammalian target of rapamycin complex 2 (mTORC2) coordinates pulmonary artery smooth muscle cell metabolism, proliferation, and survival in pulmonary arterial hypertension.
Goncharov DA, Kudryashova TV, Ziai H, Ihida-Stansbury K, DeLisser H, Krymskaya VP, Tuder RM, Kawut SM, Goncharova EA. Goncharov DA, et al. Among authors: tuder rm. Circulation. 2014 Feb 25;129(8):864-74. doi: 10.1161/CIRCULATIONAHA.113.004581. Epub 2013 Nov 22. Circulation. 2014. PMID: 24270265 Free PMC article.
Protective role of IL-6 in vascular remodeling in Schistosoma pulmonary hypertension.
Graham BB, Chabon J, Kumar R, Kolosionek E, Gebreab L, Debella E, Edwards M, Diener K, Shade T, Bifeng G, Bandeira A, Butrous G, Jones K, Geraci M, Tuder RM. Graham BB, et al. Among authors: tuder rm. Am J Respir Cell Mol Biol. 2013 Dec;49(6):951-9. doi: 10.1165/rcmb.2012-0532OC. Am J Respir Cell Mol Biol. 2013. PMID: 23815102 Free PMC article.
339 results