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A peroxisome proliferator-activated receptor-alpha (PPARalpha) cDNA cloned from guinea-pig liver encodes a protein with similar properties to the mouse PPARalpha: implications for species differences in responses to peroxisome proliferators.
Tugwood JD, Holden PR, James NH, Prince RA, Roberts RA. Tugwood JD, et al. Arch Toxicol. 1998 Feb;72(3):169-77. doi: 10.1007/s002040050483. Arch Toxicol. 1998. PMID: 9520140
Aortic Binding of AZD5248: Mechanistic Insight and Reactivity Assays To Support Lead Optimzation.
Bragg RA, Brocklehurst S, Gustafsson F, Goodman J, Hickling K, MacFaul PA, Swallow S, Tugwood J. Bragg RA, et al. Among authors: tugwood j. Chem Res Toxicol. 2015 Oct 19;28(10):1991-9. doi: 10.1021/acs.chemrestox.5b00236. Epub 2015 Sep 16. Chem Res Toxicol. 2015. PMID: 26351880
Fibrodysplasia induced in dog skin by a matrix metalloproteinase (MMP) inhibitor--a mechanistic analysis.
Tugwood JD, Kelsall J, Coverley LC, Westwood FR, Haque K, Huby RD. Tugwood JD, et al. Toxicol Sci. 2012 May;127(1):236-45. doi: 10.1093/toxsci/kfs075. Epub 2012 Feb 9. Toxicol Sci. 2012. PMID: 22323515
Gene expression profiling for pharmaceutical safety assessment.
Huby R, Tugwood JD. Huby R, et al. Among authors: tugwood jd. Expert Opin Drug Metab Toxicol. 2005 Aug;1(2):247-60. doi: 10.1517/17425255.1.2.247. Expert Opin Drug Metab Toxicol. 2005. PMID: 16922640 Review.
Peroxisome proliferator-activated receptor alpha: role in rodent liver cancer and species differences.
Holden PR, Tugwood JD. Holden PR, et al. Among authors: tugwood jd. J Mol Endocrinol. 1999 Feb;22(1):1-8. doi: 10.1677/jme.0.0220001. J Mol Endocrinol. 1999. PMID: 9924174 Review.
The peroxisome proliferator-activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs.
Issemann I, Prince RA, Tugwood JD, Green S. Issemann I, et al. Among authors: tugwood jd. J Mol Endocrinol. 1993 Aug;11(1):37-47. doi: 10.1677/jme.0.0110037. J Mol Endocrinol. 1993. PMID: 8240670
Immediate-early gene expression during regenerative and mitogen-induced liver growth in the rat.
Holden PR, Odum J, Soames AR, Foster JR, Elcombe CR, Tugwood JD. Holden PR, et al. Among authors: tugwood jd. J Biochem Mol Toxicol. 1998;12(2):79-82. doi: 10.1002/(sici)1099-0461(1998)12:2<79::aid-jbt2>;2-l. J Biochem Mol Toxicol. 1998. PMID: 9443064
Orphans await a real purpose in life.
Tugwood JD. Tugwood JD. Hum Exp Toxicol. 1996 Apr;15(4):363-4. doi: 10.1177/096032719601500415. Hum Exp Toxicol. 1996. PMID: 8845229 No abstract available.
Peroxisome proliferator-activated receptors: structures and function.
Tugwood JD, Aldridge TC, Lambe KG, Macdonald N, Woodyatt NJ. Tugwood JD, et al. Ann N Y Acad Sci. 1996 Dec 27;804:252-65. doi: 10.1111/j.1749-6632.1996.tb18620.x. Ann N Y Acad Sci. 1996. PMID: 8993548
The peroxisome proliferator (PP) response element upstream of the human acyl CoA oxidase gene is inactive among a sample human population: significance for species differences in response to PPs.
Woodyatt NJ, Lambe KG, Myers KA, Tugwood JD, Roberts RA. Woodyatt NJ, et al. Among authors: tugwood jd. Carcinogenesis. 1999 Mar;20(3):369-72. doi: 10.1093/carcin/20.3.369. Carcinogenesis. 1999. PMID: 10190548
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