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Tumor cell membrane-bound heat shock protein 70 elicits antitumor immunity.
Chen X, Tao Q, Yu H, Zhang L, Cao X. Chen X, et al. Immunol Lett. 2002 Nov 1;84(2):81-7. doi: 10.1016/s0165-2478(02)00042-1. Immunol Lett. 2002. PMID: 12270543
A novel membrane-bound heat shock protein 70 (mbHSP70) was expressed on the surface of the mouse mastocytoma cell line P815 to enhance immunogenicity of tumor cells. ...It implied that the non-specific immunity …
A novel membrane-bound heat shock protein 70 (mbHSP70) was expressed on the surface of the mouse m …
Heat Shock Protein-Peptide and HSP-Based Immunotherapies for the Treatment of Cancer.
Shevtsov M, Multhoff G. Shevtsov M, et al. Front Immunol. 2016 Apr 29;7:171. doi: 10.3389/fimmu.2016.00171. eCollection 2016. Front Immunol. 2016. PMID: 27199993 Free PMC article. Review.
In contrast to normal cells, tumor cells have higher cytosolic heat shock protein 70 and Hsp90 levels, which contribute to tumor cell propagation, metastasis, and protection against apoptosis. In addition to their int …
In contrast to normal cells, tumor cells have higher cytosolic heat shock protein 70 and Hs …
[Antitumor therapeutic effect induced by intestine-carcinoma cells vaccine expressing membrane-bound heat shock protein 70].
Huang CX, Yu H, Yang GG, Wang QQ, Shen FP, Li D, Cao XT. Huang CX, et al. Zhonghua Wei Chang Wai Ke Za Zhi. 2005 May;8(3):255-8. Zhonghua Wei Chang Wai Ke Za Zhi. 2005. PMID: 16167242 Chinese.
OBJECTIVE: To develop a new vaccine expressing membrane-bound heat shock protein 70 (mbHSP70) and further study its antitumor therapeutic effect. ...CONCLUSION: A new vaccine expressing mbHSP70 has more potent antitumor i …
OBJECTIVE: To develop a new vaccine expressing membrane-bound heat shock protein 70 (mbHSP70) and …
Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins.
Didelot C, Lanneau D, Brunet M, Joly AL, De Thonel A, Chiosis G, Garrido C. Didelot C, et al. Curr Med Chem. 2007;14(27):2839-47. doi: 10.2174/092986707782360079. Curr Med Chem. 2007. PMID: 18045130 Review.
Stress or heat shock proteins (Hsps) Hsp90, Hsp70 and Hsp27 are chaperones that assist the proteins in their folding, stability, assembly into multi-protein complexes and transport across cellular membranes. ...In contrast to intracellular Hsps, …
Stress or heat shock proteins (Hsps) Hsp90, Hsp70 and Hsp27 are chaperones that assist the proteins in th …