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Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors.
Tunaru S, Althoff TF, Nüsing RM, Diener M, Offermanns S. Tunaru S, et al. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9179-84. doi: 10.1073/pnas.1201627109. Epub 2012 May 21. Proc Natl Acad Sci U S A. 2012. PMID: 22615395 Free PMC article.
PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect.
Tunaru S, Kero J, Schaub A, Wufka C, Blaukat A, Pfeffer K, Offermanns S. Tunaru S, et al. Nat Med. 2003 Mar;9(3):352-5. doi: 10.1038/nm824. Epub 2003 Feb 3. Nat Med. 2003. PMID: 12563315
GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors.
Ahmed K, Tunaru S, Offermanns S. Ahmed K, et al. Among authors: tunaru s. Trends Pharmacol Sci. 2009 Nov;30(11):557-62. doi: 10.1016/j.tips.2009.09.001. Trends Pharmacol Sci. 2009. PMID: 19837462
An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81.
Ahmed K, Tunaru S, Tang C, Müller M, Gille A, Sassmann A, Hanson J, Offermanns S. Ahmed K, et al. Among authors: tunaru s. Cell Metab. 2010 Apr 7;11(4):311-9. doi: 10.1016/j.cmet.2010.02.012. Cell Metab. 2010. PMID: 20374963
Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice.
Hanson J, Gille A, Zwykiel S, Lukasova M, Clausen BE, Ahmed K, Tunaru S, Wirth A, Offermanns S. Hanson J, et al. Among authors: tunaru s. J Clin Invest. 2010 Aug;120(8):2910-9. doi: 10.1172/JCI42273. Epub 2010 Jul 26. J Clin Invest. 2010. PMID: 20664170 Free PMC article.
Nicotinic acid (niacin): new lipid-independent mechanisms of action and therapeutic potentials.
Lukasova M, Hanson J, Tunaru S, Offermanns S. Lukasova M, et al. Among authors: tunaru s. Trends Pharmacol Sci. 2011 Dec;32(12):700-7. doi: 10.1016/j.tips.2011.08.002. Epub 2011 Sep 22. Trends Pharmacol Sci. 2011. PMID: 21944259 Review.
Conserved MIP receptor-ligand pair regulates Platynereis larval settlement.
Conzelmann M, Williams EA, Tunaru S, Randel N, Shahidi R, Asadulina A, Berger J, Offermanns S, Jékely G. Conzelmann M, et al. Among authors: tunaru s. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8224-9. doi: 10.1073/pnas.1220285110. Epub 2013 Apr 8. Proc Natl Acad Sci U S A. 2013. PMID: 23569279 Free PMC article.
Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.
Tang C, Ahmed K, Gille A, Lu S, Gröne HJ, Tunaru S, Offermanns S. Tang C, et al. Among authors: tunaru s. Nat Med. 2015 Feb;21(2):173-7. doi: 10.1038/nm.3779. Epub 2015 Jan 12. Nat Med. 2015. PMID: 25581519
Arachidonic Acid Metabolite 19(S)-HETE Induces Vasorelaxation and Platelet Inhibition by Activating Prostacyclin (IP) Receptor.
Tunaru S, Chennupati R, Nüsing RM, Offermanns S. Tunaru S, et al. PLoS One. 2016 Sep 23;11(9):e0163633. doi: 10.1371/journal.pone.0163633. eCollection 2016. PLoS One. 2016. PMID: 27662627 Free PMC article.
20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1.
Tunaru S, Bonnavion R, Brandenburger I, Preussner J, Thomas D, Scholich K, Offermanns S. Tunaru S, et al. Nat Commun. 2018 Jan 12;9(1):177. doi: 10.1038/s41467-017-02539-4. Nat Commun. 2018. PMID: 29330456 Free PMC article.
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