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1989 2
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501 results
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Filters applied: . Clear all The following term was not found in PubMed: biofunctionalizedsurfaces
Page 1
TGF-β receptors: In and beyond TGF-β signaling.
Vander Ark A, Cao J, Li X. Vander Ark A, et al. Cell Signal. 2018 Dec;52:112-120. doi: 10.1016/j.cellsig.2018.09.002. Epub 2018 Sep 7. Cell Signal. 2018. PMID: 30184463 Review.
TGF-beta ligands bind to three isoforms of the TGF-beta receptor (TGFBR) with different affinities. TGFBR1 and 2 are both serine/threonine and tyrosine kinases, but TGFBR3 does not have any kinase activity. ...The diverse effects and context dependency are either achieved …
TGF-beta ligands bind to three isoforms of the TGF-beta receptor (TGFBR) with different affinities. TGFBR1 and 2 are both serine/thre …
Tuning peptide affinity for biofunctionalized surfaces.
Hassert R, Beck-Sickinger AG. Hassert R, et al. Eur J Pharm Biopharm. 2013 Sep;85(1):69-77. doi: 10.1016/j.ejpb.2013.02.006. Epub 2013 Feb 27. Eur J Pharm Biopharm. 2013. PMID: 23454053 Review.
In contrast, the biomimetic approach attempts the functionalization of implant surfaces with compounds such as peptides, proteins, or sugars that form an artificial layer on the implant that corresponds to the naturally occurring extracellular matrix. ...Here, an overview …
In contrast, the biomimetic approach attempts the functionalization of implant surfaces with compounds such as peptides, proteins, or …
BAFF inhibition in SLE-Is tolerance restored?
Jackson SW, Davidson A. Jackson SW, et al. Immunol Rev. 2019 Nov;292(1):102-119. doi: 10.1111/imr.12810. Epub 2019 Sep 28. Immunol Rev. 2019. PMID: 31562657 Free PMC article. Review.
BAFF is a crucial survival factor for transitional and mature B cells that acts as rheostat for the maturation of low-affinity autoreactive cells. In addition, BAFF augments innate B cell responses via complex interactions with the B cell receptor (BCR) and Toll like recep …
BAFF is a crucial survival factor for transitional and mature B cells that acts as rheostat for the maturation of low-affinity autore …
Opposing Intermolecular Tuning of Ca(2+) Affinity for Calmodulin by Neurogranin and CaMKII Peptides.
Zhang P, Tripathi S, Trinh H, Cheung MS. Zhang P, et al. Biophys J. 2017 Mar 28;112(6):1105-1119. doi: 10.1016/j.bpj.2017.01.020. Biophys J. 2017. PMID: 28355539 Free PMC article.
It was shown experimentally that Ca(2+)/CaM (holoCaM) binds to the CaMKII peptide with overwhelmingly higher affinity than Ca(2+)-free CaM (apoCaM); the binding of CaMKII peptide to CaM in return increases the Ca(2+) affinity for CaM. ...In contrast, C …
It was shown experimentally that Ca(2+)/CaM (holoCaM) binds to the CaMKII peptide with overwhelmingly higher affinity than Ca( …
TCR Affinity for In Vivo Peptide-Induced Thymic Positive Selection Fine-Tunes TCR Responsiveness of Peripheral CD8(+) T Cells.
Khanom US, Ohigashi I, Fujimori S, Kondo K, Takada K, Takahama Y. Khanom US, et al. J Immunol. 2019 Aug 15;203(4):881-887. doi: 10.4049/jimmunol.1900097. Epub 2019 Jun 24. J Immunol. 2019. PMID: 31235550 Free PMC article.
The affinity for TCR interactions with self-peptide/MHC complexes (pMHC) in the thymus critically affects immature thymocytes that newly express TCRs. ...These results indicate that in vivo administration of a peptide can promote T cell selection in the thymu …
The affinity for TCR interactions with self-peptide/MHC complexes (pMHC) in the thymus critically affects immature thymocytes …
Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.
Mitra S, Ring AM, Amarnath S, Spangler JB, Li P, Ju W, Fischer S, Oh J, Spolski R, Weiskopf K, Kohrt H, Foley JE, Rajagopalan S, Long EO, Fowler DH, Waldmann TA, Garcia KC, Leonard WJ. Mitra S, et al. Immunity. 2015 May 19;42(5):826-38. doi: 10.1016/j.immuni.2015.04.018. Immunity. 2015. PMID: 25992859 Free PMC article.
Previously, we have engineered an IL-2 "superkine" with enhanced affinity for IL-2Rbeta. Here, we describe next-generation IL-2 variants that function as "receptor signaling clamps." They retained high affinity for IL-2Rbeta, inhibiting binding of endogenous IL-2, b …
Previously, we have engineered an IL-2 "superkine" with enhanced affinity for IL-2Rbeta. Here, we describe next-generation IL-2 varia …
Combined CD28 and 4-1BB Costimulation Potentiates Affinity-tuned Chimeric Antigen Receptor-engineered T Cells.
Drent E, Poels R, Ruiter R, van de Donk NWCJ, Zweegman S, Yuan H, de Bruijn J, Sadelain M, Lokhorst HM, Groen RWJ, Mutis T, Themeli M. Drent E, et al. Clin Cancer Res. 2019 Jul 1;25(13):4014-4025. doi: 10.1158/1078-0432.CCR-18-2559. Epub 2019 Apr 12. Clin Cancer Res. 2019. PMID: 30979735 Free PMC article.
However, decreasing the affinity of the CAR-target binding may compromise the overall antitumor effects. Here, we demonstrate the prime importance of the type of intracellular signaling on the function of low-affinity CAR-T cells. EXPERIMENTAL DESIGN: We used a seri …
However, decreasing the affinity of the CAR-target binding may compromise the overall antitumor effects. Here, we demonstrate the pri …
Tuning the Protein Corona of Hydrogel Nanoparticles: The Synthesis of Abiotic Protein and Peptide Affinity Reagents.
O'Brien J, Shea KJ. O'Brien J, et al. Acc Chem Res. 2016 Jun 21;49(6):1200-10. doi: 10.1021/acs.accounts.6b00125. Epub 2016 Jun 2. Acc Chem Res. 2016. PMID: 27254382 Review.
Through directed synthetic evolution of NP compositions, one can tailor the protein corona to create synthetic organic hydrogel polymer NPs with high affinity and specificity to peptide toxins, enzymes, and other functional proteins, as well as to specific domains o …
Through directed synthetic evolution of NP compositions, one can tailor the protein corona to create synthetic organic hydrogel polymer NPs …
Transferrin plays a central role in coagulation balance by interacting with clotting factors.
Tang X, Zhang Z, Fang M, Han Y, Wang G, Wang S, Xue M, Li Y, Zhang L, Wu J, Yang B, Mwangi J, Lu Q, Du X, Lai R. Tang X, et al. Cell Res. 2020 Feb;30(2):119-132. doi: 10.1038/s41422-019-0260-6. Epub 2019 Dec 6. Cell Res. 2020. PMID: 31811276 Free PMC article.
Coagulation balance is maintained through fine-tuned interactions among clotting factors, whose physiological concentrations vary substantially. ...In atherosclerosis, abnormally up-regulated transferrin interacts with and potentiates thrombin/FXIIa and blocks AT's
Coagulation balance is maintained through fine-tuned interactions among clotting factors, whose physiological concentrations vary sub …
Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T Cells Exhibit an Increased Therapeutic Index against Tumors in Mice.
Liu X, Jiang S, Fang C, Yang S, Olalere D, Pequignot EC, Cogdill AP, Li N, Ramones M, Granda B, Zhou L, Loew A, Young RM, June CH, Zhao Y. Liu X, et al. Cancer Res. 2015 Sep 1;75(17):3596-607. doi: 10.1158/0008-5472.CAN-15-0159. Cancer Res. 2015. PMID: 26330166 Free PMC article.
Affinity-tuned cells exhibited robust antitumor efficacy similar to high-affinity cells, but spared normal cells expressing physiologic target levels. The use of affinity-tuned scFvs offers a strategy to empower wider use of CAR T cells against
Affinity-tuned cells exhibited robust antitumor efficacy similar to high-affinity cells, but spared normal cells expres
501 results