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Recombinase-mediated cassette exchange (RMCE) - a rapidly-expanding toolbox for targeted genomic modifications.
Turan S, Zehe C, Kuehle J, Qiao J, Bode J. Turan S, et al. Gene. 2013 Feb 15;515(1):1-27. doi: 10.1016/j.gene.2012.11.016. Epub 2012 Nov 29. Gene. 2013. PMID: 23201421 Review.
Expanding Flp-RMCE options: the potential of Recombinase Mediated Twin-Site Targeting (RMTT).
Turan S, Qiao J, Madden S, Benham C, Kotz M, Schambach A, Bode J. Turan S, et al. Gene. 2014 Aug 10;546(2):135-44. doi: 10.1016/j.gene.2014.06.002. Epub 2014 Jun 4. Gene. 2014. PMID: 24905650 Review.
All-in-One inducible lentiviral vector systems based on drug controlled FLP recombinase.
Maetzig T, Kuehle J, Schwarzer A, Turan S, Rothe M, Chaturvedi A, Morgan M, Ha TC, Heuser M, Hammerschmidt W, Baum C, Schambach A. Maetzig T, et al. Among authors: turan s. Biomaterials. 2014 May;35(14):4345-56. doi: 10.1016/j.biomaterials.2014.01.057. Epub 2014 Feb 14. Biomaterials. 2014. PMID: 24529624
Modified lentiviral LTRs allow Flp recombinase-mediated cassette exchange and in vivo tracing of "factor-free" induced pluripotent stem cells.
Kuehle J, Turan S, Cantz T, Hoffmann D, Suerth JD, Maetzig T, Zychlinski D, Klein C, Steinemann D, Baum C, Bode J, Schambach A. Kuehle J, et al. Among authors: turan s. Mol Ther. 2014 May;22(5):919-28. doi: 10.1038/mt.2014.4. Epub 2014 Jan 17. Mol Ther. 2014. PMID: 24434935 Free PMC article.
Site-specific recombinases: from tag-and-target- to tag-and-exchange-based genomic modifications.
Turan S, Bode J. Turan S, et al. FASEB J. 2011 Dec;25(12):4088-107. doi: 10.1096/fj.11-186940. Epub 2011 Sep 2. FASEB J. 2011. PMID: 21891781 Review.
Multiplexing RMCE: versatile extensions of the Flp-recombinase-mediated cassette-exchange technology.
Turan S, Kuehle J, Schambach A, Baum C, Bode J. Turan S, et al. J Mol Biol. 2010 Sep 10;402(1):52-69. doi: 10.1016/j.jmb.2010.07.015. Epub 2010 Jul 19. J Mol Biol. 2010. PMID: 20650281
Recombinase-mediated cassette exchange (RMCE): traditional concepts and current challenges.
Turan S, Galla M, Ernst E, Qiao J, Voelkel C, Schiedlmeier B, Zehe C, Bode J. Turan S, et al. J Mol Biol. 2011 Mar 25;407(2):193-221. doi: 10.1016/j.jmb.2011.01.004. Epub 2011 Jan 15. J Mol Biol. 2011. PMID: 21241707 Review.
Precise Correction of Disease Mutations in Induced Pluripotent Stem Cells Derived From Patients With Limb Girdle Muscular Dystrophy.
Turan S, Farruggio AP, Srifa W, Day JW, Calos MP. Turan S, et al. Mol Ther. 2016 Apr;24(4):685-96. doi: 10.1038/mt.2016.40. Epub 2016 Feb 26. Mol Ther. 2016. PMID: 26916285 Free PMC article.
Tideglusib Rescues Neurite Pathology of SPG11 iPSC Derived Cortical Neurons.
Pozner T, Schray A, Regensburger M, Lie DC, Schlötzer-Schrehardt U, Winkler J, Turan S, Winner B. Pozner T, et al. Among authors: turan s. Front Neurosci. 2018 Dec 6;12:914. doi: 10.3389/fnins.2018.00914. eCollection 2018. Front Neurosci. 2018. PMID: 30574063 Free PMC article.
A novel human stem cell model for Coffin-Siris syndrome-like syndrome reveals the importance of SOX11 dosage for neuronal differentiation and survival.
Turan S, Boerstler T, Kavyanifar A, Loskarn S, Reis A, Winner B, Lie DC. Turan S, et al. Hum Mol Genet. 2019 Aug 1;28(15):2589-2599. doi: 10.1093/hmg/ddz089. Hum Mol Genet. 2019. PMID: 31035284
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