Turnbull A - Search Results

1

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites.

Pike AC, Rellos P, Niesen FH, Turnbull A, Oliver AW, Parker SA, Turk BE, Pearl LH, Knapp S. Pike AC, et al. Among authors: turnbull a. EMBO J. 2008 Feb 20;27(4):704-14. doi: 10.1038/emboj.2008.8. Epub 2008 Jan 31. EMBO J. 2008. PMID: 18239682 Free PMC article.

2

Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.

Eswaran J, von Kries JP, Marsden B, Longman E, Debreczeni JE, Ugochukwu E, Turnbull A, Lee WH, Knapp S, Barr AJ. Eswaran J, et al. Among authors: turnbull a. Biochem J. 2006 May 1;395(3):483-91. doi: 10.1042/BJ20051931. Biochem J. 2006. PMID: 16441242 Free PMC article.

3

Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization.

Turnbull AP, Kümmel D, Prinz B, Holz C, Schultchen J, Lang C, Niesen FH, Hofmann KP, Delbrück H, Behlke J, Müller EC, Jarosch E, Sommer T, Heinemann U. Turnbull AP, et al. EMBO J. 2005 Mar 9;24(5):875-84. doi: 10.1038/sj.emboj.7600565. Epub 2005 Feb 3. EMBO J. 2005. PMID: 15692564 Free PMC article.

4

Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs.

Eswaran J, Lee WH, Debreczeni JE, Filippakopoulos P, Turnbull A, Fedorov O, Deacon SW, Peterson JR, Knapp S. Eswaran J, et al. Among authors: turnbull a. Structure. 2007 Feb;15(2):201-13. doi: 10.1016/j.str.2007.01.001. Structure. 2007. PMID: 17292838 Free PMC article.

5

Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.

Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundström M, Doyle DA, Siderovski DP. Soundararajan M, et al. Among authors: turnbull ap. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6457-62. doi: 10.1073/pnas.0801508105. Epub 2008 Apr 23. Proc Natl Acad Sci U S A. 2008. PMID: 18434541 Free PMC article.

6

Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.

Shafqat N, Turnbull A, Zschocke J, Oppermann U, Yue WW. Shafqat N, et al. Among authors: turnbull a. J Mol Biol. 2010 May 14;398(4):497-506. doi: 10.1016/j.jmb.2010.03.034. Epub 2010 Mar 25. J Mol Biol. 2010. PMID: 20346956

7

RhoB can adopt a Mg2+ free conformation prior to GEF binding.

Soundararajan M, Turnbull A, Fedorov O, Johansson C, Doyle DA. Soundararajan M, et al. Among authors: turnbull a. Proteins. 2008 Jul;72(1):498-505. doi: 10.1002/prot.22017. Proteins. 2008. PMID: 18393397 No abstract available.

8

The structures of inhibitor complexes of Pyrococcus furiosus phosphoglucose isomerase provide insights into substrate binding and catalysis.

Berrisford JM, Akerboom J, Brouns S, Sedelnikova SE, Turnbull AP, van der Oost J, Salmon L, Hardré R, Murray IA, Blackburn GM, Rice DW, Baker PJ. Berrisford JM, et al. Among authors: turnbull ap. J Mol Biol. 2004 Oct 22;343(3):649-57. doi: 10.1016/j.jmb.2004.08.061. J Mol Biol. 2004. PMID: 15465052

9

Structural and functional characterization of human Iba proteins.

Schulze JO, Quedenau C, Roske Y, Adam T, Schüler H, Behlke J, Turnbull AP, Sievert V, Scheich C, Mueller U, Heinemann U, Büssow K. Schulze JO, et al. FEBS J. 2008 Sep;275(18):4627-40. doi: 10.1111/j.1742-4658.2008.06605.x. Epub 2008 Aug 11. FEBS J. 2008. PMID: 18699778 Free article.

10

Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3.

Boyd S, Brookfield JL, Critchlow SE, Cumming IA, Curtis NJ, Debreczeni J, Degorce SL, Donald C, Evans NJ, Groombridge S, Hopcroft P, Jones NP, Kettle JG, Lamont S, Lewis HJ, MacFaull P, McLoughlin SB, Rigoreau LJ, Smith JM, St-Gallay S, Stock JK, Turnbull AP, Wheatley ER, Winter J, Wingfield J. Boyd S, et al. Among authors: turnbull ap. J Med Chem. 2015 Apr 23;58(8):3611-25. doi: 10.1021/acs.jmedchem.5b00352. Epub 2015 Apr 13. J Med Chem. 2015. PMID: 25849762

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