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5,365 results
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Thiophene substituted acylguanidines as BACE1 inhibitors.
Fobare WF, Solvibile WR, Robichaud AJ, Malamas MS, Manas E, Turner J, Hu Y, Wagner E, Chopra R, Cowling R, Jin G, Bard J. Fobare WF, et al. Among authors: Turner J. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5353-6. doi: 10.1016/j.bmcl.2007.08.010. Epub 2007 Aug 11. Bioorg Med Chem Lett. 2007. PMID: 17761418
New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: exploring the S2' region.
Malamas MS, Erdei J, Gunawan I, Barnes K, Hui Y, Johnson M, Robichaud A, Zhou P, Yan Y, Solvibile W, Turner J, Fan KY, Chopra R, Bard J, Pangalos MN. Malamas MS, et al. Among authors: Turner J. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5164-70. doi: 10.1016/j.bmcl.2011.07.057. Epub 2011 Jul 23. Bioorg Med Chem Lett. 2011. PMID: 21835615
Design and synthesis of aminohydantoins as potent and selective human β-secretase (BACE1) inhibitors with enhanced brain permeability.
Malamas MS, Robichaud A, Erdei J, Quagliato D, Solvibile W, Zhou P, Morris K, Turner J, Wagner E, Fan K, Olland A, Jacobsen S, Reinhart P, Riddell D, Pangalos M. Malamas MS, et al. Among authors: Turner J. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6597-605. doi: 10.1016/j.bmcl.2010.09.029. Epub 2010 Sep 15. Bioorg Med Chem Lett. 2010. PMID: 20880704
Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors.
Malamas MS, Barnes K, Hui Y, Johnson M, Lovering F, Condon J, Fobare W, Solvibile W, Turner J, Hu Y, Manas ES, Fan K, Olland A, Chopra R, Bard J, Pangalos MN, Reinhart P, Robichaud AJ. Malamas MS, et al. Among authors: Turner J. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2068-73. doi: 10.1016/j.bmcl.2010.02.075. Epub 2010 Feb 23. Bioorg Med Chem Lett. 2010. PMID: 20223661
Di-substituted pyridinyl aminohydantoins as potent and highly selective human beta-secretase (BACE1) inhibitors.
Malamas MS, Barnes K, Johnson M, Hui Y, Zhou P, Turner J, Hu Y, Wagner E, Fan K, Chopra R, Olland A, Bard J, Pangalos M, Reinhart P, Robichaud AJ. Malamas MS, et al. Among authors: Turner J. Bioorg Med Chem. 2010 Jan 15;18(2):630-9. doi: 10.1016/j.bmc.2009.12.007. Epub 2009 Dec 6. Bioorg Med Chem. 2010. PMID: 20045648
Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors.
Malamas MS, Erdei J, Gunawan I, Turner J, Hu Y, Wagner E, Fan K, Chopra R, Olland A, Bard J, Jacobsen S, Magolda RL, Pangalos M, Robichaud AJ. Malamas MS, et al. Among authors: Turner J. J Med Chem. 2010 Feb 11;53(3):1146-58. doi: 10.1021/jm901414e. J Med Chem. 2010. PMID: 19968289
Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors.
Nowak P, Cole DC, Aulabaugh A, Bard J, Chopra R, Cowling R, Fan KY, Hu B, Jacobsen S, Jani M, Jin G, Lo MC, Malamas MS, Manas ES, Narasimhan R, Reinhart P, Robichaud AJ, Stock JR, Subrath J, Svenson K, Turner J, Wagner E, Zhou P, Ellingboe JW. Nowak P, et al. Among authors: Turner J. Bioorg Med Chem Lett. 2010 Jan 15;20(2):632-5. doi: 10.1016/j.bmcl.2009.11.052. Epub 2009 Nov 20. Bioorg Med Chem Lett. 2010. PMID: 19959359
Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors.
Malamas MS, Erdei J, Gunawan I, Barnes K, Johnson M, Hui Y, Turner J, Hu Y, Wagner E, Fan K, Olland A, Bard J, Robichaud AJ. Malamas MS, et al. Among authors: Turner J. J Med Chem. 2009 Oct 22;52(20):6314-23. doi: 10.1021/jm9006752. J Med Chem. 2009. PMID: 19757823
Potential histamine H2-receptor antagonists. 4. Benzylhistamines.
Emmett JC, Durant GJ, Ganellin CR, Roe AM, Turner JL. Emmett JC, et al. Among authors: Turner JL. J Med Chem. 1982 Oct;25(10):1168-74. doi: 10.1021/jm00352a014. J Med Chem. 1982. PMID: 6128418
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