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siRNAs: applications in functional genomics and potential as therapeutics.
Dorsett Y, Tuschl T. Dorsett Y, et al. Nat Rev Drug Discov. 2004 Apr;3(4):318-29. doi: 10.1038/nrd1345. Nat Rev Drug Discov. 2004. PMID: 15060527 Review. No abstract available.
Functional genomics: RNA sets the standard.
Tuschl T. Tuschl T. Nature. 2003 Jan 16;421(6920):220-1. doi: 10.1038/421220a. Nature. 2003. PMID: 12529623 No abstract available.
The small RNA profile during Drosophila melanogaster development.
Aravin AA, Lagos-Quintana M, Yalcin A, Zavolan M, Marks D, Snyder B, Gaasterland T, Meyer J, Tuschl T. Aravin AA, et al. Dev Cell. 2003 Aug;5(2):337-50. doi: 10.1016/s1534-5807(03)00228-4. Dev Cell. 2003. PMID: 12919683
Analysis of mammalian gene function using small interfering RNAs.
Martinez J, Patkaniowska A, Elbashir SM, Harborth J, Hossbach M, Urlaub H, Meyer J, Weber K, Vandenburgh K, Manninga H, Scaringe SA, Luehrmann R, Tuschl T. Martinez J, et al. Nucleic Acids Res Suppl. 2003;(3):333. doi: 10.1093/nass/3.1.333. Nucleic Acids Res Suppl. 2003. PMID: 14510516 No abstract available.
Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing.
Meister G, Landthaler M, Dorsett Y, Tuschl T. Meister G, et al. RNA. 2004 Mar;10(3):544-50. doi: 10.1261/rna.5235104. RNA. 2004. PMID: 14970398 Free PMC article.
RISC is a 5' phosphomonoester-producing RNA endonuclease.
Martinez J, Tuschl T. Martinez J, et al. Genes Dev. 2004 May 1;18(9):975-80. doi: 10.1101/gad.1187904. Epub 2004 Apr 22. Genes Dev. 2004. PMID: 15105377 Free PMC article.
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.
Meister G, Landthaler M, Patkaniowska A, Dorsett Y, Teng G, Tuschl T. Meister G, et al. Mol Cell. 2004 Jul 23;15(2):185-97. doi: 10.1016/j.molcel.2004.07.007. Mol Cell. 2004. PMID: 15260970
Mechanisms of gene silencing by double-stranded RNA.
Meister G, Tuschl T. Meister G, et al. Nature. 2004 Sep 16;431(7006):343-9. doi: 10.1038/nature02873. Nature. 2004. PMID: 15372041 Review.
A pancreatic islet-specific microRNA regulates insulin secretion.
Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M. Poy MN, et al. Nature. 2004 Nov 11;432(7014):226-30. doi: 10.1038/nature03076. Nature. 2004. PMID: 15538371
Identification of microRNAs of the herpesvirus family.
Pfeffer S, Sewer A, Lagos-Quintana M, Sheridan R, Sander C, Grässer FA, van Dyk LF, Ho CK, Shuman S, Chien M, Russo JJ, Ju J, Randall G, Lindenbach BD, Rice CM, Simon V, Ho DD, Zavolan M, Tuschl T. Pfeffer S, et al. Nat Methods. 2005 Apr;2(4):269-76. doi: 10.1038/nmeth746. Epub 2005 Feb 16. Nat Methods. 2005. PMID: 15782219
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