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GroEL/GroES cycling: ATP binds to an open ring before substrate protein favoring protein binding and production of the native state.
Tyagi NK, Fenton WA, Horwich AL. Tyagi NK, et al. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20264-9. doi: 10.1073/pnas.0911556106. Epub 2009 Nov 13. Proc Natl Acad Sci U S A. 2009. PMID: 19915138 Free PMC article.
Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration.
Bilguvar K, Tyagi NK, Ozkara C, Tuysuz B, Bakircioglu M, Choi M, Delil S, Caglayan AO, Baranoski JF, Erturk O, Yalcinkaya C, Karacorlu M, Dincer A, Johnson MH, Mane S, Chandra SS, Louvi A, Boggon TJ, Lifton RP, Horwich AL, Gunel M. Bilguvar K, et al. Among authors: tyagi nk. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3489-94. doi: 10.1073/pnas.1222732110. Epub 2013 Jan 28. Proc Natl Acad Sci U S A. 2013. PMID: 23359680 Free PMC article.
Double mutant MBP refolds at same rate in free solution as inside the GroEL/GroES chaperonin chamber when aggregation in free solution is prevented.
Tyagi NK, Fenton WA, Deniz AA, Horwich AL. Tyagi NK, et al. FEBS Lett. 2011 Jun 23;585(12):1969-72. doi: 10.1016/j.febslet.2011.05.031. Epub 2011 May 20. FEBS Lett. 2011. PMID: 21609718 Free PMC article.
ATP-triggered ADP release from the asymmetric chaperonin GroEL/GroES/ADP7 is not the rate-limiting step of the GroEL/GroES reaction cycle.
Tyagi NK, Fenton WA, Horwich AL. Tyagi NK, et al. FEBS Lett. 2010 Mar 5;584(5):951-3. doi: 10.1016/j.febslet.2010.01.021. Epub 2010 Jan 17. FEBS Lett. 2010. PMID: 20083109 Free PMC article.
Molecular chaperone Hsp110 rescues a vesicle transport defect produced by an ALS-associated mutant SOD1 protein in squid axoplasm.
Song Y, Nagy M, Ni W, Tyagi NK, Fenton WA, López-Giráldez F, Overton JD, Horwich AL, Brady ST. Song Y, et al. Among authors: tyagi nk. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5428-33. doi: 10.1073/pnas.1303279110. Epub 2013 Mar 18. Proc Natl Acad Sci U S A. 2013. PMID: 23509252 Free PMC article.
An evaluation of the safety of continuing trastuzumab despite overt left ventricular dysfunction.
Barron CC, Alhussein MM, Kaur U, Cosman TL, Tyagi NK, Brown M, Mukherjee SD, Ellis PM, Dhesy-Thind S, Leong DP. Barron CC, et al. Among authors: tyagi nk. Curr Oncol. 2019 Aug;26(4):240-246. doi: 10.3747/co.26.4631. Epub 2019 Aug 1. Curr Oncol. 2019. PMID: 31548803 Free PMC article.
Adjuvant Trastuzumab Therapy: Can We Balance Efficacy and Safety?
Barron CC, Tyagi NK, Alhussein MM, Mukherjee SD, Ellis PM, Dhesy-Thind S, Leong DP. Barron CC, et al. Among authors: tyagi nk. Oncologist. 2019 Nov;24(11):1405-1409. doi: 10.1634/theoncologist.2019-0263. Epub 2019 Jul 17. Oncologist. 2019. PMID: 31315962 Free PMC article.
Clinical practice guidelines in breast cancer.
Tyagi NK, Dhesy-Thind S. Tyagi NK, et al. Curr Oncol. 2018 Jun;25(Suppl 1):S151-S160. doi: 10.3747/co.25.3729. Epub 2018 Jun 13. Curr Oncol. 2018. PMID: 29910658 Free PMC article. Review.
Establishment of a Maternal Newborn Health Registry in the Belgaum District of Karnataka, India.
Kodkany BS, Derman RJ, Honnungar NV, Tyagi NK, Goudar SS, Mastiholi SC, Moore JL, McClure EM, Sloan N, Goldenberg RL. Kodkany BS, et al. Among authors: tyagi nk. Reprod Health. 2015;12 Suppl 2(Suppl 2):S3. doi: 10.1186/1742-4755-12-S2-S3. Epub 2015 Jun 8. Reprod Health. 2015. PMID: 26062791 Free PMC article.
Prevalence of pulmonary tuberculosis in Wardha district of Maharashtra, Central India.
Narang P, Mendiratta DK, Tyagi NK, Jajoo UN, Tayade AT, Parihar PH, Narang R, Mishra PS, Anjinappa SM, Chadha VK. Narang P, et al. Among authors: tyagi nk. J Epidemiol Glob Health. 2015 Dec;5(4 Suppl 1):S11-8. doi: 10.1016/j.jegh.2015.03.002. Epub 2015 Apr 30. J Epidemiol Glob Health. 2015. PMID: 25936795 Free PMC article.
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