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Dissection of a Down syndrome-associated trisomy to separate the gene dosage-dependent and -independent effects of an extra chromosome.
Xing Z, Li Y, Cortes-Gomez E, Jiang X, Gao S, Pao A, Shan J, Song Y, Perez A, Yu T, Highsmith MR, Boadu F, Conroy JM, Singh PK, Bakin AV, Cheng J, Duan Z, Wang J, Liu S, Tycko B, Yu YE. Xing Z, et al. Among authors: tycko b. Hum Mol Genet. 2023 Jun 19;32(13):2205-2218. doi: 10.1093/hmg/ddad056. Hum Mol Genet. 2023. PMID: 37014740 Free PMC article.
R-loop landscapes in the developing human brain are linked to neural differentiation and cell-type specific transcription.
LaMarca EA, Saito A, Plaza-Jennings A, Espeso-Gil S, Hellmich A, Fernando MB, Javidfar B, Liao W, Estill M, Townsley K, Florio A, Ethridge JE, Do C, Tycko B, Shen L, Kamiya A, Tsankova NM, Brennand KJ, Akbarian S. LaMarca EA, et al. Among authors: tycko b. bioRxiv [Preprint]. 2023 Jul 18:2023.07.18.549494. doi: 10.1101/2023.07.18.549494. bioRxiv. 2023. PMID: 37503149 Free PMC article. Preprint.
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression.
Yang X, Wang Z, Samovich SN, Kapralov AA, Amoscato AA, Tyurin VA, Dar HH, Li Z, Duan S, Kon N, Chen D, Tycko B, Zhang Z, Jiang X, Bayir H, Stockwell BR, Kagan VE, Gu W. Yang X, et al. Among authors: tycko b. Cell Metab. 2024 Apr 2;36(4):762-777.e9. doi: 10.1016/j.cmet.2024.01.006. Epub 2024 Feb 2. Cell Metab. 2024. PMID: 38309267 Free PMC article.
Correlating hippocampal and amygdala volumes with neuropathological burden in Down syndrome and Alzheimer's disease and related neurodegenerative pathologies using 7T postmortem MRI.
Liou JJ, Li J, Berardinelli J, Jin H, Santini T, Noh J, Farhat N, Wu M, Aizenstein HJ, Mettenburg JM, Yong WH, Head E, Ikonomovic MD, Ibrahim TS, Kofler JK; Alzheimer Biomarker Consortium—Down Syndrome. Liou JJ, et al. J Neuropathol Exp Neurol. 2025 May 1;84(5):364-378. doi: 10.1093/jnen/nlaf010. J Neuropathol Exp Neurol. 2025. PMID: 40063697 Free PMC article.
Timeline to symptomatic Alzheimer's disease in people with Down syndrome as assessed by amyloid-PET and tau-PET: a longitudinal cohort study.
Schworer EK, Zammit MD, Wang J, Handen BL, Betthauser T, Laymon CM, Tudorascu DL, Cohen AD, Zaman SH, Ances BM, Mapstone M, Head E, Christian BT, Hartley SL; Alzheimer's Biomarker Consortium–Down Syndrome (ABC–DS). Schworer EK, et al. Lancet Neurol. 2024 Dec;23(12):1214-1224. doi: 10.1016/S1474-4422(24)00426-5. Lancet Neurol. 2024. PMID: 39577922
195 results