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CYP2A6 genotype and the metabolism and disposition kinetics of nicotine.
Benowitz NL, Swan GE, Jacob P 3rd, Lessov-Schlaggar CN, Tyndale RF. Benowitz NL, et al. Clin Pharmacol Ther. 2006 Nov;80(5):457-67. doi: 10.1016/j.clpt.2006.08.011. Clin Pharmacol Ther. 2006. PMID: 17112802 Clinical Trial.
The pharmacogenetics research network: from SNP discovery to clinical drug response.
Giacomini KM, Brett CM, Altman RB, Benowitz NL, Dolan ME, Flockhart DA, Johnson JA, Hayes DF, Klein T, Krauss RM, Kroetz DL, McLeod HL, Nguyen AT, Ratain MJ, Relling MV, Reus V, Roden DM, Schaefer CA, Shuldiner AR, Skaar T, Tantisira K, Tyndale RF, Wang L, Weinshilboum RM, Weiss ST, Zineh I; Pharmacogenetics Research Network. Giacomini KM, et al. Clin Pharmacol Ther. 2007 Mar;81(3):328-45. doi: 10.1038/sj.clpt.6100087. Clin Pharmacol Ther. 2007. PMID: 17339863 Free PMC article. Review.
Breaking barriers in the genomics and pharmacogenetics of drug addiction.
Ho MK, Goldman D, Heinz A, Kaprio J, Kreek MJ, Li MD, Munafò MR, Tyndale RF. Ho MK, et al. Clin Pharmacol Ther. 2010 Dec;88(6):779-91. doi: 10.1038/clpt.2010.175. Epub 2010 Oct 27. Clin Pharmacol Ther. 2010. PMID: 20981002 Free PMC article. Review.
Plasma letrozole concentrations in postmenopausal women with breast cancer are associated with CYP2A6 genetic variants, body mass index, and age.
Desta Z, Kreutz Y, Nguyen AT, Li L, Skaar T, Kamdem LK, Henry NL, Hayes DF, Storniolo AM, Stearns V, Hoffmann E, Tyndale RF, Flockhart DA. Desta Z, et al. Clin Pharmacol Ther. 2011 Nov;90(5):693-700. doi: 10.1038/clpt.2011.174. Epub 2011 Oct 5. Clin Pharmacol Ther. 2011. PMID: 21975350 Free PMC article. Clinical Trial.
Biomarkers for smoking cessation.
Bough KJ, Lerman C, Rose JE, McClernon FJ, Kenny PJ, Tyndale RF, David SP, Stein EA, Uhl GR, Conti DV, Green C, Amur S. Bough KJ, et al. Clin Pharmacol Ther. 2013 Jun;93(6):526-38. doi: 10.1038/clpt.2013.57. Epub 2013 Mar 18. Clin Pharmacol Ther. 2013. PMID: 23588313 Free PMC article. Review.
CYP2A6 genotype but not age determines cotinine half-life in infants and children.
Dempsey DA, Sambol NC, Jacob P 3rd, Hoffmann E, Tyndale RF, Fuentes-Afflick E, Benowitz NL. Dempsey DA, et al. Clin Pharmacol Ther. 2013 Sep;94(3):400-6. doi: 10.1038/clpt.2013.114. Epub 2013 May 29. Clin Pharmacol Ther. 2013. PMID: 23714690 Free PMC article.
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