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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1959 1
1962 2
1963 2
1964 1
1967 3
1968 6
1969 5
1970 5
1971 9
1972 3
1973 8
1974 10
1975 15
1976 59
1977 125
1978 145
1979 212
1980 297
1981 430
1982 488
1983 571
1984 706
1985 812
1986 905
1987 1011
1988 1217
1989 1431
1990 1874
1991 2185
1992 2720
1993 3253
1994 3964
1995 4405
1996 4802
1997 5001
1998 5444
1999 5653
2000 6138
2001 6629
2002 6952
2003 7688
2004 8518
2005 9105
2006 9820
2007 10477
2008 10823
2009 11541
2010 12313
2011 13262
2012 14337
2013 14875
2014 14936
2015 15149
2016 14625
2017 14587
2018 14427
2019 14564
2020 15022
2021 14944
2022 13500
2023 12425
2024 13767
2025 14388
2026 4350

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330,909 results

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Page 1
Tyrosine kinase signaling in and on the endoplasmic reticulum.
Farhan H. Farhan H. Biochem Soc Trans. 2020 Feb 28;48(1):199-205. doi: 10.1042/BST20190543. Biochem Soc Trans. 2020. PMID: 32065230 Review.
Tyrosine kinases are signaling molecules that are common to all metazoans and are involved in the regulation of many cellular processes such as proliferation and survival. ...I will discuss how tyrosine kinase signaling might regulate ER proteostasis a …
Tyrosine kinases are signaling molecules that are common to all metazoans and are involved in the regulation of many cellular …
Bruton Tyrosine Kinase Degraders in B-Cell Malignancies.
Huynh T, Rodriguez-Rodriguez S, Danilov AV. Huynh T, et al. Mol Cancer Ther. 2024 May 2;23(5):619-626. doi: 10.1158/1535-7163.MCT-23-0520. Mol Cancer Ther. 2024. PMID: 38693903 Review. No abstract available.
Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1.
Kan Y, Paung Y, Seeliger MA, Miller WT. Kan Y, et al. Cells. 2023 Mar 15;12(6):900. doi: 10.3390/cells12060900. Cells. 2023. PMID: 36980241 Free PMC article. Review.
The nonreceptor tyrosine kinase (NRTK) Ack1 comprises a distinct arrangement of non-catalytic modules. Its SH3 domain has a C-terminal to the kinase domain (SH1), in contrast to the typical SH3-SH2-SH1 layout in NRTKs. The Ack1 is the only protein that shares …
The nonreceptor tyrosine kinase (NRTK) Ack1 comprises a distinct arrangement of non-catalytic modules. Its SH3 domain has a C- …
Tyrosine Kinase Inhibitors in the Treatment of Eosinophilic Neoplasms and Systemic Mastocytosis.
Gotlib J. Gotlib J. Hematol Oncol Clin North Am. 2017 Aug;31(4):643-661. doi: 10.1016/j.hoc.2017.04.009. Hematol Oncol Clin North Am. 2017. PMID: 28673393 Review.
The World Health Organization's semimolecular classification of eosinophilias emphasizes neoplasms driven by fusion tyrosine kinases. More than 80% of patients with systemic mastocytosis carry the KIT D816V mutation, the primary driver of disease pathogenesis. ...Us …
The World Health Organization's semimolecular classification of eosinophilias emphasizes neoplasms driven by fusion tyrosine kinas …
[Receptor tyrosine kinase- fusions in paediatric spindle cell tumors].
Brenner C, Sanders C, Vokuhl C. Brenner C, et al. Pathologie (Heidelb). 2023 Nov;44(6):357-365. doi: 10.1007/s00292-023-01228-y. Epub 2023 Oct 11. Pathologie (Heidelb). 2023. PMID: 37819532 Review. German.
Genetic characterization of these lesions has been constantly improving, which has led to the identification of new subgroups that were partly included in the WHO classification. Receptor tyrosine kinase fusions play a special role in these tumors and their verifica …
Genetic characterization of these lesions has been constantly improving, which has led to the identification of new subgroups that were part …
Tyrosine kinase inhibitors in lung cancer.
Thomas A, Rajan A, Giaccone G. Thomas A, et al. Hematol Oncol Clin North Am. 2012 Jun;26(3):589-605, viii. doi: 10.1016/j.hoc.2012.02.001. Epub 2012 Mar 2. Hematol Oncol Clin North Am. 2012. PMID: 22520981 Free PMC article. Review.
Identification of driver mutations in growth related protein kinases, especially tyrosine kinases, has led to clinical development of an array of tyrosine kinase inhibitors in various malignancies, including lung cancer. ...This review discusses …
Identification of driver mutations in growth related protein kinases, especially tyrosine kinases, has led to clinical …
A Novel Tyrosine Kinase Axis in Innate Immune Signaling.
Das S, Sengupta P, Veleeparambil M, Chattopadhyay S. Das S, et al. Viruses. 2025 Dec 20;18(1):10. doi: 10.3390/v18010010. Viruses. 2025. PMID: 41600774 Free PMC article. Review.
Evidence from complementary systems reveals that receptor and nonreceptor tyrosine kinases, including Src-family kinases, Syk, BTK, and EGFR, form an integrated signaling network that triggers receptor activation, trafficking, and downstream gene expression. …
Evidence from complementary systems reveals that receptor and nonreceptor tyrosine kinases, including Src-family kinases …
Advances in studies of tyrosine kinase inhibitors and their acquired resistance.
Jiao Q, Bi L, Ren Y, Song S, Wang Q, Wang YS. Jiao Q, et al. Mol Cancer. 2018 Feb 19;17(1):36. doi: 10.1186/s12943-018-0801-5. Mol Cancer. 2018. PMID: 29455664 Free PMC article. Review.
Protein tyrosine kinase (PTK) is one of the major signaling enzymes in the process of cell signal transduction, which catalyzes the transfer of ATP-gamma-phosphate to the tyrosine residues of the substrate protein, making it phosphorylation, regulating …
Protein tyrosine kinase (PTK) is one of the major signaling enzymes in the process of cell signal transduction, which c …
Protein tyrosine kinase inhibitors.
Groundwater PW, Solomons KR, Drewe JA, Munawar MA. Groundwater PW, et al. Prog Med Chem. 1996;33:233-329. doi: 10.1016/s0079-6468(08)70307-2. Prog Med Chem. 1996. PMID: 8776945 Review. No abstract available.
Tyrosine kinase SYK: essential functions for immunoreceptor signalling.
Turner M, Schweighoffer E, Colucci F, Di Santo JP, Tybulewicz VL. Turner M, et al. Immunol Today. 2000 Mar;21(3):148-54. doi: 10.1016/s0167-5699(99)01574-1. Immunol Today. 2000. PMID: 10689303 Review.
The tyrosine kinase SYK plays critical roles in signalling through immune receptors. Gene-targeting studies have identified the cell types that require SYK for development and function, and the receptors that use SYK as well as their downstream signalling effectors. …
The tyrosine kinase SYK plays critical roles in signalling through immune receptors. Gene-targeting studies have identified th …
330,909 results
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