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Physiologically based pharmacokinetics (PBPK).
Espié P, Tytgat D, Sargentini-Maier ML, Poggesi I, Watelet JB. Espié P, et al. Among authors: tytgat d. Drug Metab Rev. 2009;41(3):391-407. doi: 10.1080/10837450902891360. Drug Metab Rev. 2009. PMID: 19601719 Review.
The pharmacokinetics, CNS pharmacodynamics and adverse event profile of brivaracetam after single increasing oral doses in healthy males.
Sargentini-Maier ML, Rolan P, Connell J, Tytgat D, Jacobs T, Pigeolet E, Riethuisen JM, Stockis A. Sargentini-Maier ML, et al. Among authors: tytgat d. Br J Clin Pharmacol. 2007 Jun;63(6):680-8. doi: 10.1111/j.1365-2125.2006.02829.x. Epub 2007 Jan 12. Br J Clin Pharmacol. 2007. PMID: 17223857 Free PMC article. Clinical Trial.
Brivaracetam, a selective high-affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action.
Nicolas JM, Hannestad J, Holden D, Kervyn S, Nabulsi N, Tytgat D, Huang Y, Chanteux H, Staelens L, Matagne A, Mathy FX, Mercier J, Stockis A, Carson RE, Klitgaard H. Nicolas JM, et al. Among authors: tytgat d. Epilepsia. 2016 Feb;57(2):201-9. doi: 10.1111/epi.13267. Epub 2015 Dec 10. Epilepsia. 2016. PMID: 26663401 Free article.
Adenosine 2A receptor occupancy by tozadenant and preladenant in rhesus monkeys.
Barret O, Hannestad J, Alagille D, Vala C, Tavares A, Papin C, Morley T, Fowles K, Lee H, Seibyl J, Tytgat D, Laruelle M, Tamagnan G. Barret O, et al. Among authors: tytgat d. J Nucl Med. 2014 Oct;55(10):1712-8. doi: 10.2967/jnumed.114.142067. Epub 2014 Jul 31. J Nucl Med. 2014. PMID: 25082853 Free article.
[(11)C]UCB-A, a novel PET tracer for synaptic vesicle protein 2A.
Estrada S, Lubberink M, Thibblin A, Sprycha M, Buchanan T, Mestdagh N, Kenda B, Mercier J, Provins L, Gillard M, Tytgat D, Antoni G. Estrada S, et al. Among authors: tytgat d. Nucl Med Biol. 2016 Jun;43(6):325-32. doi: 10.1016/j.nucmedbio.2016.03.004. Epub 2016 Mar 17. Nucl Med Biol. 2016. PMID: 27260773
11 results