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Refined prognostic role of CD68-positive tumor macrophages in the context of the cellular micromilieu of classical Hodgkin lymphoma.
Tzankov A, Matter MS, Dirnhofer S. Tzankov A, et al. Pathobiology. 2010;77(6):301-8. doi: 10.1159/000321567. Epub 2011 Jan 24. Pathobiology. 2010. PMID: 21266828
OBJECTIVE: Classical Hodgkin lymphoma (HL) consists of neoplastic Hodgkin and Reed-Sternberg cells (HRSC) and a nonneoplastic micromilieu that greatly outnumbers the HRSC. ...Recently, the number of CD68-positive macrophages was correlated with adverse survival in HL, and …
OBJECTIVE: Classical Hodgkin lymphoma (HL) consists of neoplastic Hodgkin and Reed-Sternberg cells (HRSC) and a nonneoplastic micromi …
High-throughput tissue microarray analysis of G1-cyclin alterations in classical Hodgkin's lymphoma indicates overexpression of cyclin E1.
Tzankov A, Zimpfer A, Lugli A, Krugmann J, Went P, Schraml P, Maurer R, Ascani S, Pileri S, Geley S, Dirnhofer S. Tzankov A, et al. J Pathol. 2003 Feb;199(2):201-7. doi: 10.1002/path.1279. J Pathol. 2003. PMID: 12533833
Deregulation of G1-cyclins (CCN) plays a key role in the pathogenesis of many human malignancies, including non-Hodgkin's lymphomas (NHLs). ...To facilitate analysis of aberrant gene expression in cHL, a lymphoma tissue microarray (TMA) containing 752 cores of 330 d …
Deregulation of G1-cyclins (CCN) plays a key role in the pathogenesis of many human malignancies, including non-Hodgkin's lymphomas ( …
Prognostic significance of CD20 expression in classical Hodgkin lymphoma: a clinicopathological study of 119 cases.
Tzankov A, Krugmann J, Fend F, Fischhofer M, Greil R, Dirnhofer S. Tzankov A, et al. Clin Cancer Res. 2003 Apr;9(4):1381-6. Clin Cancer Res. 2003. PMID: 12684408
EXPERIMENTAL DESIGN: CD20 expression was investigated in a series of 119 cases of cHL treated at a single institution where complete clinical follow-up was available. ...Within a mean follow-up period of 12 years, univariate analysis revealed a signifi …
EXPERIMENTAL DESIGN: CD20 expression was investigated in a series of 119 cases of cHL treated at a single institution where co …
Longer failure-free survival interval of Epstein-Barr virus-associated classical Hodgkin's lymphoma: a single-institution study.
Krugmann J, Tzankov A, Gschwendtner A, Fischhofer M, Greil R, Fend F, Dirnhofer S. Krugmann J, et al. Among authors: tzankov a. Mod Pathol. 2003 Jun;16(6):566-73. doi: 10.1097/01.MP.0000071843.09960.BF. Mod Pathol. 2003. PMID: 12808062
For assessment of the Epstein-Barr virus subtype (A/B) and latent membrane protein1 gene configuration, the polymerase chain reaction was employed. ...This large single-center study demonstrates a low prevalence of Epstein-Barr virus positivity in classical Hodgkin' …
For assessment of the Epstein-Barr virus subtype (A/B) and latent membrane protein1 gene configuration, the polymerase chain reaction …
Expression of B-cell markers in classical hodgkin lymphoma: a tissue microarray analysis of 330 cases.
Tzankov A, Zimpfer A, Pehrs AC, Lugli A, Went P, Maurer R, Pileri S, Dirnhofer S. Tzankov A, et al. Mod Pathol. 2003 Nov;16(11):1141-7. doi: 10.1097/01.MP.0000093627.51090.3F. Mod Pathol. 2003. PMID: 14614054
The aim of the present study was to assess expression of the B-cell-related antigens CD20, CD79a, and CD138 in classical Hodgkin lymphoma using a tissue microarray consisting of 330 classical Hodgkin lymphoma cases. ...Comparing the tissue microarray results with those fro …
The aim of the present study was to assess expression of the B-cell-related antigens CD20, CD79a, and CD138 in classical Hodgkin lymphoma us …
Aberrant expression of cell cycle regulators in Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma.
Tzankov A, Zimpfer A, Went P, Maurer R, Pileri SA, Geley S, Dirnhofer S. Tzankov A, et al. Mod Pathol. 2005 Jan;18(1):90-6. doi: 10.1038/modpathol.3800276. Mod Pathol. 2005. PMID: 15389259
In addition, 98% of Hodgkin's and Reed-Sternberg cells in 99% (250/253) of the cases stained strongly positive for cyclin A. ...In contrast to other tumors, expression of PCNA or cyclin A had no prognostic value for patient survival....
In addition, 98% of Hodgkin's and Reed-Sternberg cells in 99% (250/253) of the cases stained strongly positive for cyclin A. ...In co …
High specificity of combined TRAP and DBA.44 expression for hairy cell leukemia.
Went PT, Zimpfer A, Pehrs AC, Sabattini E, Pileri SA, Maurer R, Terracciano L, Tzankov A, Sauter G, Dirnhofer S. Went PT, et al. Among authors: tzankov a. Am J Surg Pathol. 2005 Apr;29(4):474-8. doi: 10.1097/01.pas.0000155152.56736.06. Am J Surg Pathol. 2005. PMID: 15767800
A combined immunohistochemical positivity for DBA.44 and tartrate-resistant phosphatase was previously found in 100% of HCL and suggested to be specific for this diagnosis. To further assess the diagnostic specificity and sensitivity of this immunohistochemical approach in
A combined immunohistochemical positivity for DBA.44 and tartrate-resistant phosphatase was previously found in 100% of HCL and sugge
Rare expression of T-cell markers in classical Hodgkin's lymphoma.
Tzankov A, Bourgau C, Kaiser A, Zimpfer A, Maurer R, Pileri SA, Went P, Dirnhofer S. Tzankov A, et al. Mod Pathol. 2005 Dec;18(12):1542-9. doi: 10.1038/modpathol.3800473. Mod Pathol. 2005. PMID: 16056244
Hodgkin's and Reed-Sternberg cells of T-cell marker-positive cases were microdissected and analyzed by a multiplex polymerase chain reaction for clonal immunoglobulin heavy chain- and T-cell receptor gamma gene rearrangements. ...In positive cases, a mean fraction o …
Hodgkin's and Reed-Sternberg cells of T-cell marker-positive cases were microdissected and analyzed by a multiplex polymerase chain r …
Angiogenesis in nodal B cell lymphomas: a high throughput study.
Tzankov A, Heiss S, Ebner S, Sterlacci W, Schaefer G, Augustin F, Fiegl M, Dirnhofer S. Tzankov A, et al. J Clin Pathol. 2007 May;60(5):476-82. doi: 10.1136/jcp.2006.038661. Epub 2006 Jun 21. J Clin Pathol. 2007. PMID: 16790692 Free PMC article.
AIM: To assess the biological significance of vascular endothelial growth factor (VEGF) A, VEGF receptor (Flk-1) and cyclooxygenase 2 (COX2) expression with respect to microvessel density (MVD), proliferative activity (Ki-67), expression of p53 and clinical presentation in …
AIM: To assess the biological significance of vascular endothelial growth factor (VEGF) A, VEGF receptor (Flk-1) and cyclooxygenase 2 …
Pathobiology of classical Hodgkin lymphoma.
Tzankov A, Dirnhofer S. Tzankov A, et al. Pathobiology. 2006;73(3):107-25. doi: 10.1159/000095558. Pathobiology. 2006. PMID: 17085956 Review.
The pathologic HRSC arise from germinal center or immediate postgerminal cells that lack detectable immunoglobulin/B-cell antigen receptor expression, with a consequent loss of B-cell identity; very few cHL cases are of T-cell origin. ...HRSC are characterized by a
The pathologic HRSC arise from germinal center or immediate postgerminal cells that lack detectable immunoglobulin/B-cell antigen receptor e …
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