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Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy.
Karakikes I, Stillitano F, Nonnenmacher M, Tzimas C, Sanoudou D, Termglinchan V, Kong CW, Rushing S, Hansen J, Ceholski D, Kolokathis F, Kremastinos D, Katoulis A, Ren L, Cohen N, Gho JMIH, Tsiapras D, Vink A, Wu JC, Asselbergs FW, Li RA, Hulot JS, Kranias EG, Hajjar RJ. Karakikes I, et al. Among authors: tzimas c. Nat Commun. 2015 Apr 29;6:6955. doi: 10.1038/ncomms7955. Nat Commun. 2015. PMID: 25923014 Free PMC article.
Cardioprotection by H2S engages a cGMP-dependent protein kinase G/phospholamban pathway.
Bibli SI, Andreadou I, Chatzianastasiou A, Tzimas C, Sanoudou D, Kranias E, Brouckaert P, Coletta C, Szabo C, Kremastinos DT, Iliodromitis EK, Papapetropoulos A. Bibli SI, et al. Among authors: tzimas c. Cardiovasc Res. 2015 Jun 1;106(3):432-42. doi: 10.1093/cvr/cvv129. Epub 2015 Apr 13. Cardiovasc Res. 2015. PMID: 25870184 Free PMC article.
Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant.
Tzimas C, Johnson DM, Santiago DJ, Vafiadaki E, Arvanitis DA, Davos CH, Varela A, Athanasiadis NC, Dimitriou C, Katsimpoulas M, Sonntag S, Kryzhanovska M, Shmerling D, Lehnart SE, Sipido KR, Kranias EG, Sanoudou D. Tzimas C, et al. Cardiovasc Res. 2017 Sep 1;113(11):1403-1417. doi: 10.1093/cvr/cvx113. Cardiovasc Res. 2017. PMID: 28859293
The expanding role of epigenetics.
Kalozoumi G, Tzimas C, Sanoudou D. Kalozoumi G, et al. Among authors: tzimas c. Glob Cardiol Sci Pract. 2012 Jul 4;2012(1):7. doi: 10.5339/gcsp.2012.7. eCollection 2012. Glob Cardiol Sci Pract. 2012. PMID: 25610838 Free PMC article. Review. No abstract available.
Notch Represses Transcription by PRC2 Recruitment to the Ternary Complex.
Han X, Ranganathan P, Tzimas C, Weaver KL, Jin K, Astudillo L, Zhou W, Zhu X, Li B, Robbins DJ, Capobianco AJ. Han X, et al. Among authors: tzimas c. Mol Cancer Res. 2017 Sep;15(9):1173-1183. doi: 10.1158/1541-7786.MCR-17-0241. Epub 2017 Jun 5. Mol Cancer Res. 2017. PMID: 28584023 Free PMC article.
WIPI1 is a conserved mediator of right ventricular failure.
Tzimas C, Rau CD, Buergisser PE, Jean-Louis G Jr, Lee K, Chukwuneke J, Dun W, Wang Y, Tsai EJ. Tzimas C, et al. JCI Insight. 2019 Apr 25;5(11):e122929. doi: 10.1172/jci.insight.122929. JCI Insight. 2019. PMID: 31021818 Free PMC article.
17 results