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Page 1
Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles.
Billmann M, Costanzo M, Zhang X, Hassan AZ, Rahman M, Brown KR, Chan KS, Tong AHY, Pons C, Ward HN, Ross C, van Leeuwen J, Aregger M, Lawson KA, Mair B, Roth AF, Sen NE, Forster DT, Tan G, Mero P, Masud SN, Lee Y, Aguilera-Uribe M, Ušaj M, Almeida SMT, Aulakh K, Bhojoo U, Birkadze S, Budijono N, Cai X, Caumanns JJ, Chalmers JJ, Chandrashekhar M, Chang D, Climie R, Dasgupta K, Drazic A, Echenique JIR, Gacesa R, Farias AG, Habsid A, Horecka I, Kantautas K, Ji F, Kim DK, Lee SY, Liang W, Lim HJ, Lin K, Lu X, Maier M, Nami B, Nixon A, Mikolajewicz N, Mokhtaridoost M, Nedyalkova L, Rohde T, Rodrigues MS, Soste M, Schultz E, Wang W, Seetharaman A, Shuteriqi E, Sizova O, Taylor DT, Tereshchenko M, Tieu D, Turowec J, Ubhi T, Varland S, Wang KE, Wang ZY, Wei J, Xiao YX, Maass PG, Reversade B, Brown GW, Cravatt BF, Dixon SJ, Wyatt HDM, Röst HL, Roth FP, Xia T, Bader GD, Loewith R, Davis NG, Andrews B, Myers CL, Moffat J, Boone C. Billmann M, et al. Among authors: usaj m. Cell. 2026 Apr 27:S0092-8674(26)00345-4. doi: 10.1016/j.cell.2026.03.044. Online ahead of print. Cell. 2026. PMID: 42049019 Free article.
A global genetic interaction map of a human cell reveals conserved principles of genetic networks.
Billmann M, Costanzo M, Zhang X, Hassan AZ, Rahman M, Brown KR, Chan KS, Tong AHY, Pons C, Ward HN, Ross C, van Leeuwen J, Aregger M, Lawson KA, Mair B, Roth AF, Sen NE, Forster D, Tan G, Mero P, Masud SN, Lee Y, Aguilera-Uribe M, Usaj M, Almeida SMT, Aulakh K, Bhojoo U, Birkadze S, Budijono N, Cai X, Caumanns JJ, Chandrashekhar M, Chang D, Climie R, Dasgupta K, Drazic A, Rojas Echenique JI, Gacesa R, Granda Farias A, Habsid A, Horecka I, Kantautas K, Ji F, Kim DK, Lee SY, Liang W, Lim J, Lin K, Lu X, Nami B, Nixon A, Mikolajewicz N, Nedyalkova L, Rohde T, Sartori Rodrigues M, Soste M, Schultz E, Wang W, Seetharaman A, Shuteriqi E, Sizova O, Thomson Taylor D, Tereshchenko M, Tieu D, Turowec J, Ubhi T, Varland S, Wang KE, Wang ZY, Wei J, Xiao YX, Brown GW, Cravatt BF, Dixon SJ, Wyatt HDM, Röst HL, Roth FP, Xia T, Bader GD, Loewith R, Davis NG, Andrews B, Myers CL, Moffat J, Boone C. Billmann M, et al. Among authors: usaj m. bioRxiv [Preprint]. 2025 Jul 2:2025.06.30.662193. doi: 10.1101/2025.06.30.662193. bioRxiv. 2025. PMID: 40631273 Free PMC article. Preprint.
A global genetic interaction network maps a wiring diagram of cellular function.
Costanzo M, VanderSluis B, Koch EN, Baryshnikova A, Pons C, Tan G, Wang W, Usaj M, Hanchard J, Lee SD, Pelechano V, Styles EB, Billmann M, van Leeuwen J, van Dyk N, Lin ZY, Kuzmin E, Nelson J, Piotrowski JS, Srikumar T, Bahr S, Chen Y, Deshpande R, Kurat CF, Li SC, Li Z, Usaj MM, Okada H, Pascoe N, San Luis BJ, Sharifpoor S, Shuteriqi E, Simpkins SW, Snider J, Suresh HG, Tan Y, Zhu H, Malod-Dognin N, Janjic V, Przulj N, Troyanskaya OG, Stagljar I, Xia T, Ohya Y, Gingras AC, Raught B, Boutros M, Steinmetz LM, Moore CL, Rosebrock AP, Caudy AA, Myers CL, Andrews B, Boone C. Costanzo M, et al. Among authors: usaj mm, usaj m. Science. 2016 Sep 23;353(6306):aaf1420. doi: 10.1126/science.aaf1420. Science. 2016. PMID: 27708008 Free PMC article.
Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens.
Hart T, Tong AHY, Chan K, Van Leeuwen J, Seetharaman A, Aregger M, Chandrashekhar M, Hustedt N, Seth S, Noonan A, Habsid A, Sizova O, Nedyalkova L, Climie R, Tworzyanski L, Lawson K, Sartori MA, Alibeh S, Tieu D, Masud S, Mero P, Weiss A, Brown KR, Usaj M, Billmann M, Rahman M, Constanzo M, Myers CL, Andrews BJ, Boone C, Durocher D, Moffat J. Hart T, et al. Among authors: usaj m. G3 (Bethesda). 2017 Aug 7;7(8):2719-2727. doi: 10.1534/g3.117.041277. G3 (Bethesda). 2017. PMID: 28655737 Free PMC article.
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.
Aregger M, Lawson KA, Billmann M, Costanzo M, Tong AHY, Chan K, Rahman M, Brown KR, Ross C, Usaj M, Nedyalkova L, Sizova O, Habsid A, Pawling J, Lin ZY, Abdouni H, Wong CJ, Weiss A, Mero P, Dennis JW, Gingras AC, Myers CL, Andrews BJ, Boone C, Moffat J. Aregger M, et al. Among authors: usaj m. Nat Metab. 2020 Jun;2(6):499-513. doi: 10.1038/s42255-020-0211-z. Epub 2020 Jun 1. Nat Metab. 2020. PMID: 32694731 Free PMC article.
Systematic analysis of bypass suppression of essential genes.
van Leeuwen J, Pons C, Tan G, Wang ZY, Hou J, Weile J, Gebbia M, Liang W, Shuteriqi E, Li Z, Lopes M, Ušaj M, Dos Santos Lopes A, van Lieshout N, Myers CL, Roth FP, Aloy P, Andrews BJ, Boone C. van Leeuwen J, et al. Among authors: usaj m. Mol Syst Biol. 2020 Sep;16(9):e9828. doi: 10.15252/msb.20209828. Mol Syst Biol. 2020. PMID: 32939983 Free PMC article.
Environmental robustness of the global yeast genetic interaction network.
Costanzo M, Hou J, Messier V, Nelson J, Rahman M, VanderSluis B, Wang W, Pons C, Ross C, Ušaj M, San Luis BJ, Shuteriqi E, Koch EN, Aloy P, Myers CL, Boone C, Andrews B. Costanzo M, et al. Among authors: usaj m. Science. 2021 May 7;372(6542):eabf8424. doi: 10.1126/science.abf8424. Science. 2021. PMID: 33958448 Free PMC article.
Quantitative analysis of genetic interactions in human cells from genome-wide CRISPR-Cas9 screens.
Billmann M, Costanzo M, Rahman M, Chan K, Yan Tong AH, Ward HN, Hassan AZ, Zhang X, Brown KR, Rohde T, Shaw AH, Ross C, van Leeuwen J, Aregger M, Lawson K, Mair B, Mero P, Usaj M, Andrews B, Boone C, Moffat J, Myers CL. Billmann M, et al. Among authors: usaj m. bioRxiv [Preprint]. 2026 Jan 5:2025.06.30.662330. doi: 10.1101/2025.06.30.662330. bioRxiv. 2026. PMID: 41542642 Free PMC article. Preprint.
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