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Year Number of Results
2018 3
2019 3
2020 9
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14 results
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E-cadherin is required for metastasis in multiple models of breast cancer.
Padmanaban V, Krol I, Suhail Y, Szczerba BM, Aceto N, Bader JS, Ewald AJ. Padmanaban V, et al. Nature. 2019 Sep;573(7774):439-444. doi: 10.1038/s41586-019-1526-3. Epub 2019 Sep 4. Nature. 2019. PMID: 31485072 Free PMC article.
Twist1-Induced Epithelial Dissemination Requires Prkd1 Signaling.
Georgess D, Padmanaban V, Sirka OK, Coutinho K, Choi A, Frid G, Neumann NM, Inoue T, Ewald AJ. Georgess D, et al. Cancer Res. 2020 Jan 15;80(2):204-218. doi: 10.1158/0008-5472.CAN-18-3241. Epub 2019 Nov 1. Cancer Res. 2020. PMID: 31676574 Free PMC article.
Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity.
Li L, Knutsdottir H, Hui K, Weiss MJ, He J, Philosophe B, Cameron AM, Wolfgang CL, Pawlik TM, Ghiaur G, Ewald AJ, Mezey E, Bader JS, Selaru FM. Li L, et al. JCI Insight. 2019 Jan 24;4(2):e121490. doi: 10.1172/jci.insight.121490. Online ahead of print. JCI Insight. 2019. PMID: 30674722 Free PMC article.
Cancer cells educate natural killer cells to a metastasis-promoting cell state.
Chan IS, Knútsdóttir H, Ramakrishnan G, Padmanaban V, Warrier M, Ramirez JC, Dunworth M, Zhang H, Jaffee EM, Bader JS, Ewald AJ. Chan IS, et al. J Cell Biol. 2020 Sep 7;219(9):e202001134. doi: 10.1083/jcb.202001134. J Cell Biol. 2020. PMID: 32645139 Free article.
Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects.
Jiao Z, Cai H, Long Y, Sirka OK, Padmanaban V, Ewald AJ, Devreotes PN. Jiao Z, et al. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4158-4168. doi: 10.1073/pnas.1917938117. Epub 2020 Feb 12. Proc Natl Acad Sci U S A. 2020. PMID: 32051246 Free PMC article.
Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome.
Huang W, Navarro-Serer B, Jeong YJ, Chianchiano P, Xia L, Luchini C, Veronese N, Dowiak C, Ng T, Trujillo MA, Huang B, Pflüger MJ, Macgregor-Das AM, Lionheart G, Jones D, Fujikura K, Nguyen-Ngoc KV, Neumann NM, Groot VP, Hasanain A, van Oosten AF, Fischer SE, Gallinger S, Singhi AD, Zureikat AH, Brand RE, Gaida MM, Heinrich S, Burkhart RA, He J, Wolfgang CL, Goggins MG, Thompson ED, Roberts NJ, Ewald AJ, Wood LD. Huang W, et al. Cancer Res. 2020 Jul 1;80(13):2804-2817. doi: 10.1158/0008-5472.CAN-19-1523. Epub 2020 May 6. Cancer Res. 2020. PMID: 32376602
A Tissue-Engineered 3D Microvessel Model Reveals the Dynamics of Mosaic Vessel Formation in Breast Cancer.
Silvestri VL, Henriet E, Linville RM, Wong AD, Searson PC, Ewald AJ. Silvestri VL, et al. Cancer Res. 2020 Oct 1;80(19):4288-4301. doi: 10.1158/0008-5472.CAN-19-1564. Epub 2020 Jul 14. Cancer Res. 2020. PMID: 32665356
Between-tumor and within-tumor heterogeneity in invasive potential.
Padmanaban V, Tsehay Y, Cheung KJ, Ewald AJ, Bader JS. Padmanaban V, et al. PLoS Comput Biol. 2020 Jan 21;16(1):e1007464. doi: 10.1371/journal.pcbi.1007464. eCollection 2020 Jan. PLoS Comput Biol. 2020. PMID: 31961880 Free PMC article.
Metastasis inside-out: dissemination of cancer cell clusters with inverted polarity.
Ewald AJ. Ewald AJ. EMBO J. 2018 Apr 3;37(7):e99144. doi: 10.15252/embj.201899144. Epub 2018 Mar 9. EMBO J. 2018. PMID: 29523585 Free PMC article.
Myoepithelial cells are a dynamic barrier to epithelial dissemination.
Sirka OK, Shamir ER, Ewald AJ. Sirka OK, et al. J Cell Biol. 2018 Oct 1;217(10):3368-3381. doi: 10.1083/jcb.201802144. Epub 2018 Jul 30. J Cell Biol. 2018. PMID: 30061105 Free PMC article.
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