U19-CA67771/CA/NCI NIH HHS/United States[Grant Number] - Search Results

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Year	Number of Results
1996	1
1997	2
2005	1
2007	1
2022	0

Page 1

Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome.

Capell BC, Erdos MR, Madigan JP, Fiordalisi JJ, Varga R, Conneely KN, Gordon LB, Der CJ, Cox AD, Collins FS. Capell BC, et al. Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12879-84. doi: 10.1073/pnas.0506001102. Epub 2005 Aug 29. Proc Natl Acad Sci U S A. 2005. PMID: 16129833 Free PMC article.

Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth.

Falsetti SC, Wang DA, Peng H, Carrico D, Cox AD, Der CJ, Hamilton AD, Sebti SM. Falsetti SC, et al. Mol Cell Biol. 2007 Nov;27(22):8003-14. doi: 10.1128/MCB.00057-07. Epub 2007 Sep 17. Mol Cell Biol. 2007. PMID: 17875936 Free PMC article.

Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation.

McGuire TF, Qian Y, Vogt A, Hamilton AD, Sebti SM. McGuire TF, et al. J Biol Chem. 1996 Nov 1;271(44):27402-7. doi: 10.1074/jbc.271.44.27402. J Biol Chem. 1996. PMID: 8910319 Free article.

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.

Lerner EC, Zhang TT, Knowles DB, Qian Y, Hamilton AD, Sebti SM. Lerner EC, et al. Oncogene. 1997 Sep;15(11):1283-8. doi: 10.1038/sj.onc.1201296. Oncogene. 1997. PMID: 9315095

Inhibition of Ras prenylation: a signaling target for novel anti-cancer drug design.

Lerner EC, Hamilton AD, Sebti SM. Lerner EC, et al. Anticancer Drug Des. 1997 Jun;12(4):229-38. Anticancer Drug Des. 1997. PMID: 9199657 Review.

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