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Year Number of Results
2013 1
2014 1
2015 1
2016 1
2017 2
2018 2
2019 1
2020 4
2021 3
2022 2
2023 1
2024 3

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19 results

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Page 1
Mitophagy defect mediates the aging-associated hallmarks in Hutchinson-Gilford progeria syndrome.
Sun Y, Xu L, Li Y, Jia S, Wang G, Cen X, Xu Y, Cao Z, Wang J, Shen N, Hu L, Zhang J, Mao J, Xia H, Liu Z, Fu X. Sun Y, et al. Aging Cell. 2024 Mar 14:e14143. doi: 10.1111/acel.14143. Online ahead of print. Aging Cell. 2024. PMID: 38482753 Free article.
Mechanistically, we discovered that mitophagy affected the aging-associated phenotypes of HGPS-MSCs by inhibiting the STING-NF-qB pathway and the downstream transcription of senescence-associated secretory phenotypes (SASPs). Furthermore, by utilizing UMI-77, an eff …
Mechanistically, we discovered that mitophagy affected the aging-associated phenotypes of HGPS-MSCs by inhibiting the STING-NF-qB pathway an …
Discovery and optimization of (2-naphthylthio)acetic acid derivative as selective Bfl-1 inhibitor.
Niu P, Xu H, Fan M. Niu P, et al. Bioorg Med Chem Lett. 2024 Mar 15;101:129658. doi: 10.1016/j.bmcl.2024.129658. Epub 2024 Feb 18. Bioorg Med Chem Lett. 2024. PMID: 38373466
In order to tackle this issue, compound library was screened and a hit compound UMI-77 was identified. We modified its chemical structure to remove the characteristic of PAINS (pan-assay interference compounds), demonstrated the real binding affinity and achieved se …
In order to tackle this issue, compound library was screened and a hit compound UMI-77 was identified. We modified its chemica …
Novel mitophagy inducer alleviates lupus nephritis by reducing myeloid cell activation and autoantigen presentation.
Wang H, Shen M, Ma Y, Lan L, Jiang X, Cen X, Guo G, Zhou Q, Yuan M, Chen J, Xia H, Xiao L, Han F. Wang H, et al. Kidney Int. 2024 Apr;105(4):759-774. doi: 10.1016/j.kint.2023.12.017. Epub 2024 Jan 29. Kidney Int. 2024. PMID: 38296028 Free article.
UMI-77 also restored mitochondrial function and attenuated proinflammatory phenotypes in lupus DCs. Adoptive transfer of DCs from MRL/lpr mice augmented serum anti-dsDNA IgG, urine protein and T-cell infiltration of the kidney in MRL/MpJ mice, which could be prevent …
UMI-77 also restored mitochondrial function and attenuated proinflammatory phenotypes in lupus DCs. Adoptive transfer of DCs f …
UMI-77 Modulates the Complement Cascade Pathway and Inhibits Inflammatory Factor Storm in Sepsis Based on TMT Proteomics and Inflammation Array Glass Chip.
Xu Y, Chen Q, Jiang Y, Liang X, Wang T, Xu Y. Xu Y, et al. J Proteome Res. 2023 Nov 3;22(11):3464-3474. doi: 10.1021/acs.jproteome.3c00317. Epub 2023 Oct 13. J Proteome Res. 2023. PMID: 37830896
Sepsis is a systemic inflammatory response syndrome caused by infection, which has no specific drug at present. UMI-77 can significantly improve the survival rate of septic mice; the detailed role of UMI-77 and its underlying mechanisms in sepsis are n …
Sepsis is a systemic inflammatory response syndrome caused by infection, which has no specific drug at present. UMI-77 can sig …
[Effect of Curcumin on Apoptosis of Acute T-Lymphoblastic Leukemia Cells induced by UMI-77 and Its Related Mechanism].
Xu Z, Song L, Wu YH, Cao B. Xu Z, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2022 Jun;30(3):695-703. doi: 10.19746/j.cnki.issn.1009-2137.2022.03.006. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2022. PMID: 35680792 Chinese.
AbstractObjective: To explore the effect and mechanism of curcumin on human T-cell acute lymphoblastic leukemia (T-ALL) cell apoptosis induced by Mcl-1 small molecule inhibitors UMI-77. METHODS: T-ALL cell line Molt-4 was cultured, and the cells were treated with di …
AbstractObjective: To explore the effect and mechanism of curcumin on human T-cell acute lymphoblastic leukemia (T-ALL) cell apoptosis induc …
Mitophagy induced by UMI-77 preserves mitochondrial fitness in renal tubular epithelial cells and alleviates renal fibrosis.
Jin L, Yu B, Liu G, Nie W, Wang J, Chen J, Xiao L, Xia H, Han F, Yang Y. Jin L, et al. FASEB J. 2022 Jun;36(6):e22342. doi: 10.1096/fj.202200199RR. FASEB J. 2022. PMID: 35524750
In this study, we explored the effect of mitophagy activation by UMI-77, a compound recently verified to induce mitophagy, on murine CKD model of unilateral ureteral obstruction (UUO) in vivo and TECs in vitro. ...Then, we found UMI-77 could effectivel …
In this study, we explored the effect of mitophagy activation by UMI-77, a compound recently verified to induce mitophagy, on …
The combination of C-Myc rearrangement and 1q21 gain is associated with poor prognosis in multiple myeloma.
Jin Y, Yu X, Du J, Li H, Tang W, Jia C, Zan Y, Chen M, Zhang Y, Yu M, Rong W, Zhou D, Zhuang J. Jin Y, et al. Ann Hematol. 2021 May;100(5):1251-1260. doi: 10.1007/s00277-021-04475-2. Epub 2021 Mar 8. Ann Hematol. 2021. PMID: 33686491
Mcl-1 silencing by siRNA inhibited Myc protein expression in three myeloma cell lines. Treatment with the small-molecule Mcl-1 inhibitor, UMI-77, produced similar results. Overall, the combination of Myc rearrangement and 1q21 gain was associated with particularly p …
Mcl-1 silencing by siRNA inhibited Myc protein expression in three myeloma cell lines. Treatment with the small-molecule Mcl-1 inhibitor, …
Targeting MCL1 to induce mitophagy is a potential therapeutic strategy for Alzheimer disease.
Cen X, Xu X, Xia H. Cen X, et al. Autophagy. 2021 Mar;17(3):818-819. doi: 10.1080/15548627.2020.1860542. Epub 2020 Dec 20. Autophagy. 2021. PMID: 33342330 Free PMC article.
In recent studies, we have identified a small molecule compound, UMI-77, that can safely and effectively induce mitophagy. UMI-77 is an established BH3-mimetic for MCL1 and was developed to induce apoptosis in cancer cells. ...UMI-77 effe …
In recent studies, we have identified a small molecule compound, UMI-77, that can safely and effectively induce mitophagy. …
Synthesis and evaluation of a UMI-77-based fluorescent probe for selective detecting Mcl-1 protein and imaging in living cancer cells.
Li J, Hou X, Bai J, Zhou Y, Chen C, Yang X, Fang H. Li J, et al. Bioorg Med Chem. 2021 Jan 1;29:115850. doi: 10.1016/j.bmc.2020.115850. Epub 2020 Nov 7. Bioorg Med Chem. 2021. PMID: 33229135
Development of efficient fluorescent probes for detecting the overexpressed Mcl-1 protein in living cells is imperative for the diagnosis and treatment of cancers. In this paper, a new UMI-77 based fluorescent probe (DNSH), was synthesized and characterized. ...
Development of efficient fluorescent probes for detecting the overexpressed Mcl-1 protein in living cells is imperative for the diagnosis an …
Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer's disease mouse model.
Cen X, Chen Y, Xu X, Wu R, He F, Zhao Q, Sun Q, Yi C, Wu J, Najafov A, Xia H. Cen X, et al. Nat Commun. 2020 Nov 12;11(1):5731. doi: 10.1038/s41467-020-19547-6. Nat Commun. 2020. PMID: 33184293 Free PMC article.
Here, we screen a library of 2024 FDA-approved drugs or drug candidates, revealing UMI-77 as an unexpected mitophagy activator. UMI-77 is an established BH3-mimetic for MCL-1 and was developed to induce apoptosis in cancer cells. ...Finally, we found t …
Here, we screen a library of 2024 FDA-approved drugs or drug candidates, revealing UMI-77 as an unexpected mitophagy activator …
19 results