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71 results

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Page 1
UNC5C-knockdown enhances the growth and metastasis of breast cancer cells by potentiating the integrin alpha6/beta4 signaling pathway.
Yuan M, Xie F, Xia X, Zhong K, Lian L, Zhang S, Yuan L, Ye J. Yuan M, et al. Int J Oncol. 2020 Jan;56(1):139-150. doi: 10.3892/ijo.2019.4931. Epub 2019 Dec 2. Int J Oncol. 2020. PMID: 31789389 Free PMC article.
The present study found that UNC5C is heterogeneously expressed in breast cancer cell lines. By knocking down UNC5C in SK-BR-3 and ZR-75-30 cells and overexpressing UNC5c in MDA-MB-231 cells, it was demonstrated that UNC5C exerts an inhibitory e …
The present study found that UNC5C is heterogeneously expressed in breast cancer cell lines. By knocking down UNC5C in …
Methylation of the UNC5C gene and its protein expression in colorectal cancer.
Wu J, Wang G, He B, Chen X, An Y. Wu J, et al. Tumour Biol. 2017 Apr;39(4):1010428317697564. doi: 10.1177/1010428317697564. Tumour Biol. 2017. PMID: 28378635 Free article.
The expression of UNC5C is lost or markedly reduced in a large proportion of cancers at the messenger RNA level. ...UNC5C may have a critical role in the pathogenesis of colorectal cancers and be a valuable prognostic factor of colorectal cancers …
The expression of UNC5C is lost or markedly reduced in a large proportion of cancers at the messenger RNA level. ...UNC5C …
GPC3-Unc5 receptor complex structure and role in cell migration.
Akkermans O, Delloye-Bourgeois C, Peregrina C, Carrasquero-Ordaz M, Kokolaki M, Berbeira-Santana M, Chavent M, Reynaud F, Raj R, Agirre J, Aksu M, White ES, Lowe E, Ben Amar D, Zaballa S, Huo J, Pakos I, McCubbin PTN, Comoletti D, Owens RJ, Robinson CV, Castellani V, Del Toro D, Seiradake E. Akkermans O, et al. Cell. 2022 Oct 13;185(21):3931-3949.e26. doi: 10.1016/j.cell.2022.09.025. Cell. 2022. PMID: 36240740 Free PMC article.
Neural migration is a critical step during brain development that requires the interactions of cell-surface guidance receptors. Cancer cells often hijack these mechanisms to disseminate. Here, we reveal crystal structures of Uncoordinated-5 receptor D (Unc5D) in complex wi …
Neural migration is a critical step during brain development that requires the interactions of cell-surface guidance receptors. Cancer …
Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles.
Küry S, Garrec C, Airaud F, Breheret F, Guibert V, Frenard C, Jiao S, Bonneau D, Berthet P, Bossard C, Ingster O, Cauchin E, Bezieau S. Küry S, et al. World J Gastroenterol. 2014 Jan 7;20(1):204-13. doi: 10.3748/wjg.v20.i1.204. World J Gastroenterol. 2014. PMID: 24415873 Free PMC article.
AIM: To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer (CRC). METHODS: We screened patients with familial CRC forms as well as patients with sporadic CRCs. In a first time, we analyzed exon …
AIM: To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cance …
UNC5C Receptor Proteolytic Cleavage by Active AEP Promotes Dopaminergic Neuronal Degeneration in Parkinson's Disease.
Chen G, Ahn EH, Kang SS, Xia Y, Liu X, Zhang Z, Ye K. Chen G, et al. Adv Sci (Weinh). 2022 Mar;9(7):e2103396. doi: 10.1002/advs.202103396. Epub 2022 Jan 12. Adv Sci (Weinh). 2022. PMID: 35023303 Free PMC article.
Moreover, UNC5C is fragmented by AEP in PD brains, inversely correlated with reduced netrin-1 levels. ...Hence, the findings demonstrate that netrin-1 reduction and UNC5C truncation by AEP contribute to PD pathogenesis....
Moreover, UNC5C is fragmented by AEP in PD brains, inversely correlated with reduced netrin-1 levels. ...Hence, the findings demonstr …
Aberrant methylation of the UNC5C gene is frequently detected in advanced colorectal cancer.
Hibi K, Mizukami H, Shirahata A, Goto T, Sakata M, Saito M, Ishibashi K, Kigawa G, Nemoto H, Sanada Y. Hibi K, et al. Anticancer Res. 2009 Jan;29(1):271-3. Anticancer Res. 2009. PMID: 19331160 Free article.
Recently, two reports indicated that UNC5C methylation was closely associated with loss of gene expression in colorectal cancer. ...RESULTS: Aberrant methylation of the UNC5C gene was detected in 34 out of the 49 (69%) primary colon carcinomas, suggesting tha …
Recently, two reports indicated that UNC5C methylation was closely associated with loss of gene expression in colorectal cancer …
Scarce evidence of the causal role of germline mutations in UNC5C in hereditary colorectal cancer and polyposis.
Mur P, Sánchez-Cuartielles E, Aussó S, Aiza G, Valdés-Mas R, Pineda M, Navarro M, Brunet J, Urioste M, Lázaro C, Moreno V, Capellá G, Puente XS, Valle L. Mur P, et al. Sci Rep. 2016 Feb 8;6:20697. doi: 10.1038/srep20697. Sci Rep. 2016. PMID: 26852919 Free PMC article.
Germline mutations in UNC5C have been suggested to increase colorectal cancer (CRC) risk, thus causing hereditary CRC. ...In conclusion, our results suggest that the contribution of germline mutations in UNC5C to hereditary colorectal cancer and to pol …
Germline mutations in UNC5C have been suggested to increase colorectal cancer (CRC) risk, thus causing hereditary CRC. ...In c …
Significant Pattern of Promoter Hypermethylation of UNC5C Gene in Colorectal Cancer and Its Implication in Late Stage Disease.
Guroo SA, Malik AA, Afroze D, Ali S, Pandith AA, Yusuf A. Guroo SA, et al. Asian Pac J Cancer Prev. 2018 May 26;19(5):1185-1188. doi: 10.22034/APJCP.2018.19.5.1185. Asian Pac J Cancer Prev. 2018. PMID: 29801399 Free PMC article.
Purpose: In the present study, we evaluated the role of promoter hypermethylation of UNC5C gene (one of the netrin-1 receptors) in colorectal cancer patients of Kashmiri population (North India). Hypermethylation in tumour tissue was detected by Methylation- Specifi …
Purpose: In the present study, we evaluated the role of promoter hypermethylation of UNC5C gene (one of the netrin-1 receptors) in co …
Variants in the netrin-1 receptor UNC5C prevent apoptosis and increase risk of familial colorectal cancer.
Coissieux MM, Tomsic J, Castets M, Hampel H, Tuupanen S, Andrieu N, Comeras I, Drouet Y, Lasset C, Liyanarachchi S, Mazelin L, Puisieux A, Saurin JC, Scoazec JY, Wang Q, Aaltonen L, Tanner SM, de la Chapelle A, Bernet A, Mehlen P. Coissieux MM, et al. Gastroenterology. 2011 Dec;141(6):2039-46. doi: 10.1053/j.gastro.2011.08.041. Epub 2011 Sep 3. Gastroenterology. 2011. PMID: 21893118 Free PMC article.
We investigated whether specific variants in UNC5C increase risk of colorectal cancer (CRC). METHODS: We analyzed the sequence of UNC5C in blood samples from 1801 patients with CRC and 4152 controls from 3 cohorts (France, United States, and Finland). ...Tran …
We investigated whether specific variants in UNC5C increase risk of colorectal cancer (CRC). METHODS: We analyzed the sequence …
Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer.
Shin SK, Nagasaka T, Jung BH, Matsubara N, Kim WH, Carethers JM, Boland CR, Goel A. Shin SK, et al. Gastroenterology. 2007 Dec;133(6):1849-57. doi: 10.1053/j.gastro.2007.08.074. Epub 2007 Sep 5. Gastroenterology. 2007. PMID: 18054557 Free PMC article.
Both receptors frequently are down-regulated in colorectal cancer (CRC). Although CRCs frequently lose DCC owing to deletions at 18q, the mechanism for the UNC5C loss is poorly understood. We hypothesized that UNC5C is silenced epigenetically in CRC, and that …
Both receptors frequently are down-regulated in colorectal cancer (CRC). Although CRCs frequently lose DCC owing to deletions at 18q, …
71 results