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Ebselen, a seleno-organic antioxidant, as an electrophile.
Sakurai T, Kanayama M, Shibata T, Itoh K, Kobayashi A, Yamamoto M, Uchida K. Sakurai T, et al. Among authors: uchida k. Chem Res Toxicol. 2006 Sep;19(9):1196-204. doi: 10.1021/tx0601105. Chem Res Toxicol. 2006. PMID: 16978024
A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway.
Morimitsu Y, Nakagawa Y, Hayashi K, Fujii H, Kumagai T, Nakamura Y, Osawa T, Horio F, Itoh K, Iida K, Yamamoto M, Uchida K. Morimitsu Y, et al. Among authors: uchida k. J Biol Chem. 2002 Feb 1;277(5):3456-63. doi: 10.1074/jbc.M110244200. Epub 2001 Nov 12. J Biol Chem. 2002. PMID: 11706044 Free article.
., Naito, Y., Torii, Y., Kumagai, T., Osawa, T., Ohigashi, H., Satoh, K., Imagawa, M., and Uchida, K. (2000) J. Biol. Chem. 275, 11291-11299.) ...
., Naito, Y., Torii, Y., Kumagai, T., Osawa, T., Ohigashi, H., Satoh, K., Imagawa, M., and Uchida, K. (2000) J. Biol. C …
Thioredoxin as a molecular target of cyclopentenone prostaglandins.
Shibata T, Yamada T, Ishii T, Kumazawa S, Nakamura H, Masutani H, Yodoi J, Uchida K. Shibata T, et al. Among authors: uchida k. J Biol Chem. 2003 Jul 11;278(28):26046-54. doi: 10.1074/jbc.M303690200. Epub 2003 Apr 22. J Biol Chem. 2003. PMID: 12709421 Free article.
Induction of reversible cysteine-targeted protein oxidation by an endogenous electrophile 15-deoxy-delta12,14-prostaglandin J2.
Ishii T, Uchida K. Ishii T, et al. Among authors: uchida k. Chem Res Toxicol. 2004 Oct;17(10):1313-22. doi: 10.1021/tx049860+. Chem Res Toxicol. 2004. PMID: 15487891
We have previously shown that a prostaglandin D(2) metabolite, 15-deoxy-delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), is the potent inducer of intracellular oxidative stress on human neuroblastoma SH-SY5Y cells [Kondo, M., Oya-Ito, T., Kumagai, T., Osawa, T., and Uchida, …
We have previously shown that a prostaglandin D(2) metabolite, 15-deoxy-delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), is the potent inducer …
5,590 results