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Activation of human vascular endothelial cells by IFN-gamma: acquisition of HLA class II expression, TSST-1-binding activity and accessory activity in T cell activation by the toxin.
Araake M, Uchiyama T, Imanishi K, Yan XJ. Araake M, et al. Int Arch Allergy Appl Immunol. 1991;96(1):55-61. doi: 10.1159/000235535. Int Arch Allergy Appl Immunol. 1991. PMID: 1752697
The IFN-gamma-stimulated HUVEC exhibited AC activity in TSST-1-induced IL-2 production by T cells from human peripheral blood mononuclear cells. ...In view of the fact that TSST-1 binds directly to HLA class II molecules and activates human T cells in association wi …
The IFN-gamma-stimulated HUVEC exhibited AC activity in TSST-1-induced IL-2 production by T cells from human peripheral blood mononuc …
Change of specific T cells in an emerging neonatal infectious disease induced by a bacterial superantigen.
Takahashi N, Kato H, Imanishi K, Ohki T, Uehara R, Momoi MY, Nishida H, Uchiyama T. Takahashi N, et al. Microbiol Immunol. 2009 Sep;53(9):524-30. doi: 10.1111/j.1348-0421.2009.00155.x. Microbiol Immunol. 2009. PMID: 19703246
The aim of the present study was to analyze the change in Vbeta2(+) T cells reactive to TSST-1 in NTED in order to establish T-cell-targeted diagnostic criteria for NTED. ...In 18 of the 75 patients, we conducted multiple examinations of the T cells and monit …
The aim of the present study was to analyze the change in Vbeta2(+) T cells reactive to TSST-1 in NTED in order to establish T
Genetic background influences Th cell differentiation by controlling the capacity for IL-2-induced IL-4 production by naive CD4+ T cells.
Yagi J, Arimura Y, Takatori H, Nakajima H, Iwamoto I, Uchiyama T. Yagi J, et al. Int Immunol. 2006 Dec;18(12):1681-90. doi: 10.1093/intimm/dxl102. Epub 2006 Oct 11. Int Immunol. 2006. PMID: 17035345
Comparative studies using T(h)2-prone BALB/c and T(h)1-prone C57BL/6 mice were performed to clarify the influence of genetic background on T(h) cell differentiation. The results showed IL-4, the production of which is induced by IL-2, to be much more abundant …
Comparative studies using T(h)2-prone BALB/c and T(h)1-prone C57BL/6 mice were performed to clarify the influence of genetic b …
A severe case of neonatal toxic shock syndrome-like exanthematous disease with superantigen-induced high T cell response.
Miki M, Uchiyama T, Kato H, Nishida H, Takahashi N. Miki M, et al. Pediatr Infect Dis J. 2006 Oct;25(10):950-2. doi: 10.1097/01.inf.0000238144.22201.4a. Pediatr Infect Dis J. 2006. PMID: 17006297
We present the case of a patient with NTED who exhibited exceptionally severe clinical symptoms and an adult-type T cell response to the causative toxin TSS toxin-1....
We present the case of a patient with NTED who exhibited exceptionally severe clinical symptoms and an adult-type T cell response to …
Early and definitive diagnosis of toxic shock syndrome by detection of marked expansion of T-cell-receptor VBeta2-positive T cells.
Matsuda Y, Kato H, Yamada R, Okano H, Ohta H, Imanishi K, Kikuchi K, Totsuka K, Uchiyama T. Matsuda Y, et al. Emerg Infect Dis. 2003 Mar;9(3):387-9. doi: 10.3201/eid0903.020360. Emerg Infect Dis. 2003. PMID: 12643839 Free PMC article.
We describe two cases of early toxic shock syndrome, caused by the superantigen produced from methicillin-resistant Staphylococcus aureus and diagnosed on the basis of an expansion of T-cell-receptor VBeta2-positive T cells. ...
We describe two cases of early toxic shock syndrome, caused by the superantigen produced from methicillin-resistant Staphylococcus aureus an …
Inhibitory effect of antimicrobial agents and anisodamine on the staphylococcal superantigenic toxin-induced overproduction of proinflammatory cytokines by human peripheral blood mononuclear cells.
Kushiya K, Nakagawa S, Taneike I, Iwakura N, Imanishi K, Uchiyama T, Tsukada H, Gejyo F, Yamamoto T. Kushiya K, et al. J Infect Chemother. 2005 Aug;11(4):192-5. doi: 10.1007/s10156-005-0389-8. J Infect Chemother. 2005. PMID: 16133711
TSST-1 abnormally activates T cells to overproduce inflammatory cytokines (such as tumor necrosis factor-alpha, interleukin-2, and interferon-gamma) leading to shock. ...
TSST-1 abnormally activates T cells to overproduce inflammatory cytokines (such as tumor necrosis factor-alpha, interleukin-2, and in …
Characterization of novel staphylococcal enterotoxin-like toxin type P.
Omoe K, Imanishi K, Hu DL, Kato H, Fugane Y, Abe Y, Hamaoka S, Watanabe Y, Nakane A, Uchiyama T, Shinagawa K. Omoe K, et al. Infect Immun. 2005 Sep;73(9):5540-6. doi: 10.1128/IAI.73.9.5540-5546.2005. Infect Immun. 2005. PMID: 16113270 Free PMC article.
The expression of major histocompatibility complex class II molecules on accessory cells was required for T-cell stimulation by SElP. SElP selectively stimulated a vast number of human T cells bearing receptors Vbeta 5.1, 6, 8, 16, 18, and 21.3. These results indica …
The expression of major histocompatibility complex class II molecules on accessory cells was required for T-cell stimulation by SElP. …
Biological properties of staphylococcal enterotoxin-like toxin type R.
Omoe K, Imanishi K, Hu DL, Kato H, Takahashi-Omoe H, Nakane A, Uchiyama T, Shinagawa K. Omoe K, et al. Infect Immun. 2004 Jun;72(6):3664-7. doi: 10.1128/IAI.72.6.3664-3667.2004. Infect Immun. 2004. PMID: 15155681 Free PMC article.
Major histocompatibility complex class II molecules were required for T-cell stimulation by SElR. SElR stimulated T cells bearing receptors Vbeta 3, 11, 12, 13.2, and 14. ...
Major histocompatibility complex class II molecules were required for T-cell stimulation by SElR. SElR stimulated T cells bear …
Specific inhibitory action of anisodamine against a staphylococcal superantigenic toxin, toxic shock syndrome toxin 1 (TSST-1), leading to down-regulation of cytokine production and blocking of TSST-1 toxicity in mice.
Nakagawa S, Kushiya K, Taneike I, Imanishi K, Uchiyama T, Yamamoto T. Nakagawa S, et al. Clin Diagn Lab Immunol. 2005 Mar;12(3):399-408. doi: 10.1128/CDLI.12.3.399-408.2005. Clin Diagn Lab Immunol. 2005. PMID: 15753253 Free PMC article.
., Vbeta2+ T cells and overproduction of proinflammatory cytokines. In the present study we examined the inhibitory effect of a Chinese herbal extract, anisodamine, on TSST-1 using human peripheral blood mononuclear cells (PBMCs). ...Anisodamine acted directly on both mono …
., Vbeta2+ T cells and overproduction of proinflammatory cytokines. In the present study we examined the inhibitory effect of a Chine …
Diagnosis of toxic shock syndrome by two different systems; clinical criteria and monitoring of TSST-1-reactive T cells.
Matsuda Y, Kato H, Ono E, Kikuchi K, Muraoka M, Takagi K, Imanishi K, Itoh S, Itoh T, Ogawa T, Nitta K, Inokuchi S, Hibi T, Ohta H, Uchiyama T. Matsuda Y, et al. Microbiol Immunol. 2008 Nov;52(11):513-21. doi: 10.1111/j.1348-0421.2008.00071.x. Microbiol Immunol. 2008. PMID: 19090830
Time taken to reach the diagnosis of TSS could be significantly shortened by utilizing the findings from tracing Vbeta2(+) T cells. In vitro studies showed that TSST-1- reactive T cells from TSS patients were anergic in the early phase of their illness. Examining se …
Time taken to reach the diagnosis of TSS could be significantly shortened by utilizing the findings from tracing Vbeta2(+) T cells. I …
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