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Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy.
Shigihara N, Fukunaka A, Hara A, Komiya K, Honda A, Uchida T, Abe H, Toyofuku Y, Tamaki M, Ogihara T, Miyatsuka T, Hiddinga HJ, Sakagashira S, Koike M, Uchiyama Y, Yoshimori T, Eberhardt NL, Fujitani Y, Watada H. Shigihara N, et al. Among authors: uchiyama y. J Clin Invest. 2014 Aug;124(8):3634-44. doi: 10.1172/JCI69866. Epub 2014 Jul 18. J Clin Invest. 2014. PMID: 25036706 Free PMC article.
Exendin-4 improves β-cell function in autophagy-deficient β-cells.
Abe H, Uchida T, Hara A, Mizukami H, Komiya K, Koike M, Shigihara N, Toyofuku Y, Ogihara T, Uchiyama Y, Yagihashi S, Fujitani Y, Watada H. Abe H, et al. Among authors: uchiyama y. Endocrinology. 2013 Dec;154(12):4512-24. doi: 10.1210/en.2013-1578. Epub 2013 Oct 8. Endocrinology. 2013. PMID: 24105478
Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway.
Komiya K, Uchida T, Ueno T, Koike M, Abe H, Hirose T, Kawamori R, Uchiyama Y, Kominami E, Fujitani Y, Watada H. Komiya K, et al. Among authors: uchiyama y. Biochem Biophys Res Commun. 2010 Oct 29;401(4):561-7. doi: 10.1016/j.bbrc.2010.09.101. Epub 2010 Oct 1. Biochem Biophys Res Commun. 2010. PMID: 20888798
Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice.
Matsuda T, Kido Y, Asahara S, Kaisho T, Tanaka T, Hashimoto N, Shigeyama Y, Takeda A, Inoue T, Shibutani Y, Koyanagi M, Hosooka T, Matsumoto M, Inoue H, Uchida T, Koike M, Uchiyama Y, Akira S, Kasuga M. Matsuda T, et al. Among authors: uchiyama y. J Clin Invest. 2010 Jan;120(1):115-26. doi: 10.1172/JCI39721. Epub 2009 Dec 1. J Clin Invest. 2010. PMID: 19955657 Free PMC article.
Autophagy-physiology and pathophysiology.
Uchiyama Y, Shibata M, Koike M, Yoshimura K, Sasaki M. Uchiyama Y, et al. Histochem Cell Biol. 2008 Apr;129(4):407-20. doi: 10.1007/s00418-008-0406-y. Epub 2008 Mar 5. Histochem Cell Biol. 2008. PMID: 18320203 Free PMC article. Review.
Autophagic neuron death.
Uchiyama Y, Koike M, Shibata M, Sasaki M. Uchiyama Y, et al. Methods Enzymol. 2009;453:33-51. doi: 10.1016/S0076-6879(08)04003-2. Methods Enzymol. 2009. PMID: 19216901
1,181 results