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Page 1
A soluble activin receptor type IIb prevents the effects of androgen deprivation on body composition and bone health.
Koncarevic A, Cornwall-Brady M, Pullen A, Davies M, Sako D, Liu J, Kumar R, Tomkinson K, Baker T, Umiker B, Monnell T, Grinberg AV, Liharska K, Underwood KW, Ucran JA, Howard E, Barberio J, Spaits M, Pearsall S, Seehra J, Lachey J. Koncarevic A, et al. Among authors: ucran ja. Endocrinology. 2010 Sep;151(9):4289-300. doi: 10.1210/en.2010-0134. Epub 2010 Jun 23. Endocrinology. 2010. PMID: 20573726
Characterization of the ligand binding functionality of the extracellular domain of activin receptor type IIb.
Sako D, Grinberg AV, Liu J, Davies MV, Castonguay R, Maniatis S, Andreucci AJ, Pobre EG, Tomkinson KN, Monnell TE, Ucran JA, Martinez-Hackert E, Pearsall RS, Underwood KW, Seehra J, Kumar R. Sako D, et al. Among authors: ucran ja. J Biol Chem. 2010 Jul 2;285(27):21037-48. doi: 10.1074/jbc.M110.114959. Epub 2010 Apr 12. J Biol Chem. 2010. PMID: 20385559 Free PMC article.
A novel therapeutic approach to treating obesity through modulation of TGFβ signaling.
Koncarevic A, Kajimura S, Cornwall-Brady M, Andreucci A, Pullen A, Sako D, Kumar R, Grinberg AV, Liharska K, Ucran JA, Howard E, Spiegelman BM, Seehra J, Lachey J. Koncarevic A, et al. Among authors: ucran ja. Endocrinology. 2012 Jul;153(7):3133-46. doi: 10.1210/en.2012-1016. Epub 2012 May 1. Endocrinology. 2012. PMID: 22549226 Free PMC article.
A soluble activin type IIA receptor induces bone formation and improves skeletal integrity.
Pearsall RS, Canalis E, Cornwall-Brady M, Underwood KW, Haigis B, Ucran J, Kumar R, Pobre E, Grinberg A, Werner ED, Glatt V, Stadmeyer L, Smith D, Seehra J, Bouxsein ML. Pearsall RS, et al. Proc Natl Acad Sci U S A. 2008 May 13;105(19):7082-7. doi: 10.1073/pnas.0711263105. Epub 2008 May 6. Proc Natl Acad Sci U S A. 2008. PMID: 18460605 Free PMC article.
Treatment with a soluble receptor for activin improves bone mass and structure in the axial and appendicular skeleton of female cynomolgus macaques (Macaca fascicularis).
Fajardo RJ, Manoharan RK, Pearsall RS, Davies MV, Marvell T, Monnell TE, Ucran JA, Pearsall AE, Khanzode D, Kumar R, Underwood KW, Roberts B, Seehra J, Bouxsein ML. Fajardo RJ, et al. Among authors: ucran ja. Bone. 2010 Jan;46(1):64-71. doi: 10.1016/j.bone.2009.09.018. Epub 2009 Sep 23. Bone. 2010. PMID: 19781677
ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth.
Mitchell D, Pobre EG, Mulivor AW, Grinberg AV, Castonguay R, Monnell TE, Solban N, Ucran JA, Pearsall RS, Underwood KW, Seehra J, Kumar R. Mitchell D, et al. Among authors: ucran ja. Mol Cancer Ther. 2010 Feb;9(2):379-88. doi: 10.1158/1535-7163.MCT-09-0650. Epub 2010 Feb 2. Mol Cancer Ther. 2010. PMID: 20124460
A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength.
Baud'huin M, Solban N, Cornwall-Brady M, Sako D, Kawamoto Y, Liharska K, Lath D, Bouxsein ML, Underwood KW, Ucran J, Kumar R, Pobre E, Grinberg A, Seehra J, Canalis E, Pearsall RS, Croucher PI. Baud'huin M, et al. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12207-12. doi: 10.1073/pnas.1204929109. Epub 2012 Jul 3. Proc Natl Acad Sci U S A. 2012. PMID: 22761317 Free PMC article.
11 results