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Loss of Metabolic Flexibility in the Failing Heart.
Karwi QG, Uddin GM, Ho KL, Lopaschuk GD. Karwi QG, et al. Among authors: uddin gm. Front Cardiovasc Med. 2018 Jun 6;5:68. doi: 10.3389/fcvm.2018.00068. eCollection 2018. Front Cardiovasc Med. 2018. PMID: 29928647 Free PMC article. Review.
Empagliflozin Increases Cardiac Energy Production in Diabetes: Novel Translational Insights Into the Heart Failure Benefits of SGLT2 Inhibitors.
Verma S, Rawat S, Ho KL, Wagg CS, Zhang L, Teoh H, Dyck JE, Uddin GM, Oudit GY, Mayoux E, Lehrke M, Marx N, Lopaschuk GD. Verma S, et al. Among authors: uddin gm. JACC Basic Transl Sci. 2018 Aug 26;3(5):575-587. doi: 10.1016/j.jacbts.2018.07.006. eCollection 2018 Oct. JACC Basic Transl Sci. 2018. PMID: 30456329 Free PMC article.
Insulin directly stimulates mitochondrial glucose oxidation in the heart.
Karwi QG, Wagg CS, Altamimi TR, Uddin GM, Ho KL, Darwesh AM, Seubert JM, Lopaschuk GD. Karwi QG, et al. Among authors: uddin gm. Cardiovasc Diabetol. 2020 Dec 7;19(1):207. doi: 10.1186/s12933-020-01177-3. Cardiovasc Diabetol. 2020. PMID: 33287820 Free PMC article.
Deletion of BCATm increases insulin-stimulated glucose oxidation in the heart.
Uddin GM, Karwi QG, Pherwani S, Gopal K, Wagg CS, Biswas D, Atnasious M, Wu Y, Wu G, Zhang L, Ho KL, Pulinilkunnil T, Ussher JR, Lopaschuk GD. Uddin GM, et al. Metabolism. 2021 Nov;124:154871. doi: 10.1016/j.metabol.2021.154871. Epub 2021 Sep 1. Metabolism. 2021. PMID: 34478752
Loss of muscle PDH induces lactic acidosis and adaptive anaplerotic compensation via pyruvate-alanine cycling and glutaminolysis.
Gopal K, Abdualkader AM, Li X, Greenwell AA, Karwi QG, Altamimi TR, Saed C, Uddin GM, Darwesh AM, Jamieson KL, Kim R, Eaton F, Seubert JM, Lopaschuk GD, Ussher JR, Al Batran R. Gopal K, et al. Among authors: uddin gm. J Biol Chem. 2023 Dec;299(12):105375. doi: 10.1016/j.jbc.2023.105375. Epub 2023 Oct 20. J Biol Chem. 2023. PMID: 37865313 Free PMC article.
36 results