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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 2
1950 1
1951 2
1952 1
1955 3
1956 1
1957 1
1958 3
1959 3
1960 4
1961 1
1962 2
1963 2
1964 6
1965 7
1967 1
1968 2
1969 1
1970 2
1971 6
1972 9
1973 13
1974 7
1975 28
1976 33
1977 52
1978 33
1979 40
1980 70
1981 54
1982 56
1983 75
1984 64
1985 56
1986 59
1987 61
1988 56
1989 53
1990 39
1991 66
1992 53
1993 56
1994 62
1995 57
1996 86
1997 60
1998 48
1999 74
2000 53
2001 86
2002 65
2003 75
2004 92
2005 103
2006 91
2007 106
2008 105
2009 113
2010 118
2011 135
2012 150
2013 161
2014 153
2015 154
2016 165
2017 154
2018 149
2019 154
2020 158
2021 110
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3,787 results
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Uptake and modification of umbelliferone by various seedlings.
Hijazin T, Radwan A, Abouzeid S, Dräger G, Selmar D. Hijazin T, et al. Phytochemistry. 2019 Jan;157:194-199. doi: 10.1016/j.phytochem.2018.10.032. Epub 2018 Nov 12. Phytochemistry. 2019. PMID: 30439620
In all cases, a tremendous uptake of umbelliferone was observed. In plants that genuinely contain coumarins, the umbelliferone taken up was modified: in garden cress, it was hydroxylated and glucosylated to yield esculin, while in barley seedlings, the imported u
In all cases, a tremendous uptake of umbelliferone was observed. In plants that genuinely contain coumarins, the umbelliferone
Umbelliferone (7-hydroxycoumarin): A non-toxic antidiarrheal and antiulcerogenic coumarin.
Cruz LF, Figueiredo GF, Pedro LP, Amorin YM, Andrade JT, Passos TF, Rodrigues FF, Souza ILA, Gonçalves TPR, Dos Santos Lima LAR, Ferreira JMS, Araújo MGF. Cruz LF, et al. Biomed Pharmacother. 2020 Sep;129:110432. doi: 10.1016/j.biopha.2020.110432. Epub 2020 Jul 3. Biomed Pharmacother. 2020. PMID: 32768935 Free article.
Coumarins are an extensive class of phenolic compounds that can be found in plants, fungi and bacteria. The 7-hydroxycoumarin, also known as umbelliferone (UMB), is a compound that comes from coumarin and has been showing biological activities in other studie …
Coumarins are an extensive class of phenolic compounds that can be found in plants, fungi and bacteria. The 7-hydroxycoumarin, …
Umbelliferone derivatives exert neuroprotective effects by inhibiting monoamine oxidase A, self-amyloidbeta aggregation, and lipid peroxidation.
Seong SH, Ali MY, Jung HA, Choi JS. Seong SH, et al. Bioorg Chem. 2019 Nov;92:103293. doi: 10.1016/j.bioorg.2019.103293. Epub 2019 Sep 18. Bioorg Chem. 2019. PMID: 31557622
However, the effect of incorporating a formyl moiety in the umbelliferone scaffold has not been investigated. In this paper, we investigated the inhibitory activity of six coumarins, namely umbelliferone (1), 6-formyl umbelliferone (2), 8-formyl umbellifer
However, the effect of incorporating a formyl moiety in the umbelliferone scaffold has not been investigated. In this paper, we inves …
Xanthotoxin and umbelliferone attenuate cognitive dysfunction in a streptozotocin-induced rat model of sporadic Alzheimer's disease: The role of JAK2/STAT3 and Nrf2/HO-1 signalling pathway modulation.
Hindam MO, Sayed RH, Skalicka-Woźniak K, Budzyńska B, El Sayed NS. Hindam MO, et al. Phytother Res. 2020 Sep;34(9):2351-2365. doi: 10.1002/ptr.6686. Epub 2020 Apr 6. Phytother Res. 2020. PMID: 32250498
Xanthotoxin or umbelliferone prevented cognitive deficits in the Morris water maze and object recognition tests. In parallel, xanthotoxin or umbelliferone reduced hippocampal acetylcholinestrase activity and malondialdehyde level. ...
Xanthotoxin or umbelliferone prevented cognitive deficits in the Morris water maze and object recognition tests. In parallel, xanthot …
Umbelliferone Alleviates Lipopolysaccharide-Induced Inflammatory Responses in Acute Lung Injury by Down-Regulating TLR4/MyD88/NF-kappaB Signaling.
Wang D, Wang X, Tong W, Cui Y, Li X, Sun H. Wang D, et al. Inflammation. 2019 Apr;42(2):440-448. doi: 10.1007/s10753-018-00953-4. Inflammation. 2019. PMID: 30645708
This study investigated the protective effect and underlying mechanism of action of umbelliferone (Umb) against lipopolysaccharide (LPS)-induced acute lung injury (ALI). ...
This study investigated the protective effect and underlying mechanism of action of umbelliferone (Umb) against lipopolysaccharide (L …
Umbelliferone modulates depression-like symptoms by altering monoamines in a rat post-traumatic stress disorder model.
Lee B, Yeom M, Shim I, Lee H, Hahm DH. Lee B, et al. J Nat Med. 2020 Mar;74(2):377-386. doi: 10.1007/s11418-019-01373-w. Epub 2019 Nov 21. J Nat Med. 2020. PMID: 31755013
It is known to cause various complications, including anxiety and depression. Umbelliferone (UMB) is a natural product of the coumarin family. This substance has been reported to exert antioxidant, anti-inflammatory, neuroprotective, and other biological effects. ...
It is known to cause various complications, including anxiety and depression. Umbelliferone (UMB) is a natural product of the coumari …
Umbelliferone Inhibits Spermatogenic Defects and Testicular Injury in Lead-Intoxicated Rats by Suppressing Oxidative Stress and Inflammation, and Improving Nrf2/HO-1 Signaling.
Alotaibi MF, Al-Joufi F, Abou Seif HS, Alzoghaibi MA, Djouhri L, Ahmeda AF, Mahmoud AM. Alotaibi MF, et al. Drug Des Devel Ther. 2020 Sep 29;14:4003-4019. doi: 10.2147/DDDT.S265636. eCollection 2020. Drug Des Devel Ther. 2020. PMID: 33061305 Free PMC article.
INTRODUCTION: Lead (Pb) is an environmental toxic metal that threatens human health. Umbelliferone (UMB) is a coumarin with known medicinal and protective properties against cytotoxicity. ...
INTRODUCTION: Lead (Pb) is an environmental toxic metal that threatens human health. Umbelliferone (UMB) is a coumarin with known med …
Short-term effects of the allelochemical umbelliferone on Triticum durum L. metabolism through GC-MS based untargeted metabolomics.
Misra BB, Das V, Landi M, Abenavoli MR, Araniti F. Misra BB, et al. Plant Sci. 2020 Sep;298:110548. doi: 10.1016/j.plantsci.2020.110548. Epub 2020 Jun 5. Plant Sci. 2020. PMID: 32771160
The present study used untargeted metabolomics to investigate the short-term metabolic changes induced in wheat seedlings by the specialized metabolite umbelliferone, an allelochemical. We used 10 day-old wheat seedlings treated with 104 muM umbelliferone over a tim …
The present study used untargeted metabolomics to investigate the short-term metabolic changes induced in wheat seedlings by the specialized …
Umbelliferone Alleviates Myocardial Ischemia: the Role of Inflammation and Apoptosis.
Gan J, Qian W, Lin S. Gan J, et al. Inflammation. 2018 Mar;41(2):464-473. doi: 10.1007/s10753-017-0702-6. Inflammation. 2018. PMID: 29188498
The present study was to investigate cardioprotective effects of umbelliferone (Umb) on coronary artery ligation-induced myocardial ischemia. ...
The present study was to investigate cardioprotective effects of umbelliferone (Umb) on coronary artery ligation-induced myocardial i …
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