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Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors.
Pfefferkorn JA, Song Y, Sun KL, Miller SR, Trivedi BK, Choi C, Sorenson RJ, Bratton LD, Unangst PC, Larsen SD, Poel TJ, Cheng XM, Lee C, Erasga N, Auerbach B, Askew V, Dillon L, Hanselman JC, Lin Z, Lu G, Robertson A, Olsen K, Mertz T, Sekerke C, Pavlovsky A, Harris MS, Bainbridge G, Caspers N, Chen H, Eberstadt M. Pfefferkorn JA, et al. Among authors: unangst pc. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4538-44. doi: 10.1016/j.bmcl.2007.05.096. Epub 2007 Jun 6. Bioorg Med Chem Lett. 2007. PMID: 17574412
Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of HMG-CoA reductase.
Bratton LD, Auerbach B, Choi C, Dillon L, Hanselman JC, Larsen SD, Lu G, Olsen K, Pfefferkorn JA, Robertson A, Sekerke C, Trivedi BK, Unangst PC. Bratton LD, et al. Among authors: unangst pc. Bioorg Med Chem. 2007 Aug 15;15(16):5576-89. doi: 10.1016/j.bmc.2007.05.031. Epub 2007 May 17. Bioorg Med Chem. 2007. PMID: 17560788
Discovery of highly potent and selective benzyloxybenzyl-based peroxisome proliferator-activator receptor (PPAR) delta agonists.
Bratton LD, Filzen GF, Geyer A, Hoffman JK, Lu G, Pulaski J, Trivedi BK, Unangst PC, Xu X. Bratton LD, et al. Among authors: unangst pc. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3624-9. doi: 10.1016/j.bmcl.2007.04.046. Epub 2007 Apr 24. Bioorg Med Chem Lett. 2007. PMID: 17498950
Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor delta agonists.
Filzen GF, Bratton L, Cheng XM, Erasga N, Geyer A, Lee C, Lu G, Pulaski J, Sorenson RJ, Unangst PC, Trivedi BK, Xu X. Filzen GF, et al. Among authors: unangst pc. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3630-5. doi: 10.1016/j.bmcl.2007.04.047. Epub 2007 Apr 24. Bioorg Med Chem Lett. 2007. PMID: 17512197
2,6-di-tert-butylphenols: a new class of potent and selective PGHS-2 inhibitor.
Song Y, Connor DT, Sorenson RJ, Doubleday R, Sercel AD, Unangst PC, Gilbertsen RB, Chan K, Bornemeier DA, Dyer RD. Song Y, et al. Among authors: unangst pc. Inflamm Res. 1997 Aug;46 Suppl 2:S141-2. doi: 10.1007/s000110050145. Inflamm Res. 1997. PMID: 9297551 No abstract available.
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.
Song Y, Connor DT, Doubleday R, Sorenson RJ, Sercel AD, Unangst PC, Roth BD, Gilbertsen RB, Chan K, Schrier DJ, Guglietta A, Bornemeier DA, Dyer RD. Song Y, et al. Among authors: unangst pc. J Med Chem. 1999 Apr 8;42(7):1151-60. doi: 10.1021/jm9805081. J Med Chem. 1999. PMID: 10197959
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.
Song Y, Connor DT, Sercel AD, Sorenson RJ, Doubleday R, Unangst PC, Roth BD, Beylin VG, Gilbertsen RB, Chan K, Schrier DJ, Guglietta A, Bornemeier DA, Dyer RD. Song Y, et al. Among authors: unangst pc. J Med Chem. 1999 Apr 8;42(7):1161-9. doi: 10.1021/jm980570y. J Med Chem. 1999. PMID: 10197960
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