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Treatment with Uncaria tomentosa Promotes Apoptosis in B16-BL6 Mouse Melanoma Cells and Inhibits the Growth of B16-BL6 Tumours.
Zari A, Alfarteesh H, Buckner C, Lafrenie R. Zari A, et al. Molecules. 2021 Feb 18;26(4):1066. doi: 10.3390/molecules26041066. Molecules. 2021. PMID: 33670520 Free PMC article.
Uncaria tomentosa is a medicinal plant native to Peru that has been traditionally used in the treatment of various inflammatory disorders. ...Treatment with ethanolic extracts of Uncaria tomentosa were much more effective than treatment with aqueous ex …
Uncaria tomentosa is a medicinal plant native to Peru that has been traditionally used in the treatment of various inflammator …
Uncaria tomentosa Leaves Decoction Modulates Differently ROS Production in Cancer and Normal Cells, and Effects Cisplatin Cytotoxicity.
Kośmider A, Czepielewska E, Kuraś M, Gulewicz K, Pietrzak W, Nowak R, Nowicka G. Kośmider A, et al. Molecules. 2017 Apr 12;22(4):620. doi: 10.3390/molecules22040620. Molecules. 2017. PMID: 28417940 Free PMC article.
The results indicate that Uncaria tomentosa leaves decoction modulates differently cancer and normal cells oxidative metabolism and, enhanced cytotoxicity of CDDP against cancer cells and at the same time increased normal healthy cells resistance to ci …
The results indicate that Uncaria tomentosa leaves decoction modulates differently cancer and normal cells oxidative me …
Effect of Uncaria tomentosa Extract on Apoptosis Triggered by Oxaliplatin Exposure on HT29 Cells.
de Oliveira LZ, Farias IL, Rigo ML, Glanzner WG, Gonçalves PB, Cadoná FC, Cruz IB, Farias JG, Duarte MM, Franco L, Bertol G, Colpo E, Brites PC, Rocha JB, Leal DB. de Oliveira LZ, et al. Evid Based Complement Alternat Med. 2014;2014:274786. doi: 10.1155/2014/274786. Epub 2014 Nov 11. Evid Based Complement Alternat Med. 2014. PMID: 25505920 Free PMC article.
The objective of this study was to evaluate whether Uncaria tomentosa extract modulates apoptosis induced by chemotherapy exposure. Materials and Methods. ...Moreover, antioxidant activity may be related to apoptosis. Conclusion. Uncaria tome …
The objective of this study was to evaluate whether Uncaria tomentosa extract modulates apoptosis induced by chemothera …
Quinovic acid glycosides purified fraction from Uncaria tomentosa induces cell death by apoptosis in the T24 human bladder cancer cell line.
Dietrich F, Kaiser S, Rockenbach L, Figueiró F, Bergamin LS, da Cunha FM, Morrone FB, Ortega GG, Battastini AM. Dietrich F, et al. Food Chem Toxicol. 2014 May;67:222-9. doi: 10.1016/j.fct.2014.02.037. Epub 2014 Mar 6. Food Chem Toxicol. 2014. PMID: 24607820 Free article.
In the search for new treatments, researchers have attempted to find compounds with low toxicity. With this goal in mind, Uncaria tomentosa is noteworthy because the bark and root of this species are widely used in traditional medicine and in adjuvant therapy for th …
In the search for new treatments, researchers have attempted to find compounds with low toxicity. With this goal in mind, Uncaria …
Induction of apoptosis by Uncaria tomentosa through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia cells.
Cheng AC, Jian CB, Huang YT, Lai CS, Hsu PC, Pan MH. Cheng AC, et al. Food Chem Toxicol. 2007 Nov;45(11):2206-18. doi: 10.1016/j.fct.2007.05.016. Epub 2007 Jun 7. Food Chem Toxicol. 2007. PMID: 17619071
Uncaria tomentosa (Wild.) DC., found in the Amazon rain forest in South-America and known commonly as cat's claw, has been used in traditional medicine to prevent and treat inflammation and cancer. ...Cat's claw n-hex …
Uncaria tomentosa (Wild.) DC., found in the Amazon rain forest in South-America and known commonly as cat's c …
Uncaria tomentosa stimulates the proliferation of myeloid progenitor cells.
Farias I, do Carmo Araújo M, Zimmermann ES, Dalmora SL, Benedetti AL, Alvarez-Silva M, Asbahr AC, Bertol G, Farias J, Schetinger MR. Farias I, et al. J Ethnopharmacol. 2011 Sep 1;137(1):856-63. doi: 10.1016/j.jep.2011.07.011. Epub 2011 Jul 8. J Ethnopharmacol. 2011. PMID: 21771655 Free article.
ETHNOPHARMACOLOGICAL RELEVANCE: The Ashaninkas, indigenous people of Peru, use cat's claw (Uncaria tomentosa) to restore health. Uncaria tomentosa has antioxidant activity and works as an agent to repair DNA damage. ...These result …
ETHNOPHARMACOLOGICAL RELEVANCE: The Ashaninkas, indigenous people of Peru, use cat's claw (Uncaria tomentosa …
Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells.
Bacher N, Tiefenthaler M, Sturm S, Stuppner H, Ausserlechner MJ, Kofler R, Konwalinka G. Bacher N, et al. Br J Haematol. 2006 Mar;132(5):615-22. doi: 10.1111/j.1365-2141.2005.05907.x. Br J Haematol. 2006. PMID: 16445836
Here, we investigated for the first time the antiproliferative and apoptotic effects of highly purified oxindole alkaloids, namely isopteropodine (A1), pteropodine (A2), isomitraphylline (A3), uncarine F (A4) and mitraphylline (A5) obtained from Uncaria tomentosa, a …
Here, we investigated for the first time the antiproliferative and apoptotic effects of highly purified oxindole alkaloids, namely isopterop …
Quinovic Acid Enhances the Cytotoxicity of KHYG-1 Cells by Modulating the Ras/MAPK Signalling Pathway and Interferon-Gamma Expression.
Hsieh MJ, Lin JT, Chuang YC, Ho HY, Lo YS, Lin CC, Chen MK. Hsieh MJ, et al. J Cell Mol Med. 2025 Nov;29(22):e70957. doi: 10.1111/jcmm.70957. J Cell Mol Med. 2025. PMID: 41294043 Free PMC article.
Quinovic acid is a key constituent of cat's claw (Uncaria tomentosa) extract and exhibits antioxidant and anti-inflammatory activities. ...Our findings suggest that quinovic acid enhances NK cell cytotoxicity, showing promise as a potential ther …
Quinovic acid is a key constituent of cat's claw (Uncaria tomentosa) extract and exhibits antioxidant and …
Proapoptotic effect of Uncaria tomentosa extracts.
De Martino L, Martinot JL, Franceschelli S, Leone A, Pizza C, De Feo V. De Martino L, et al. J Ethnopharmacol. 2006 Aug 11;107(1):91-4. doi: 10.1016/j.jep.2006.02.013. Epub 2006 Mar 29. J Ethnopharmacol. 2006. PMID: 16569487
Uncaria tomentosa ("Una de gato") (Rubiaceae) is widely used in South America for treatment of gastritis, arthritis, cancer and inflammatory conditions. ...The present study investigates the possible proapoptotic mechanism via the activation of caspase3, in c …
Uncaria tomentosa ("Una de gato") (Rubiaceae) is widely used in South America for treatment of gastritis, arthritis, cancer …
Anti-proliferative and pro-apoptotic effects of Uncaria tomentosa aqueous extract in squamous carcinoma cells.
Ciani F, Tafuri S, Troiano A, Cimmino A, Fioretto BS, Guarino AM, Pollice A, Vivo M, Evidente A, Carotenuto D, Calabrò V. Ciani F, et al. J Ethnopharmacol. 2018 Jan 30;211:285-294. doi: 10.1016/j.jep.2017.09.031. Epub 2017 Sep 28. J Ethnopharmacol. 2018. PMID: 28964869
Uncaria tomentosa (Willd.) DC. (Rubiacee), also known as una de gato, is a plant that grows wild in the upper Amazon region of Peru and has been widely used in folk medicine to treat several health conditions including cancer. We have produced an aqueous extr …
Uncaria tomentosa (Willd.) DC. (Rubiacee), also known as una de gato, is a plant that grows wild in the upper Amazon region of …
14 results